Says the guy who…podcasts for a living. (And this guy too apparently). Do you know how many people met between 50-64 were just fired by the hundreds of thousands by the #federal #government? And how nobody in the private sector wants to hire anyone over age 50?

More news (not good) from NIH The renewal request from National Institute of Neurological Diseases and Stroke Director Walter Koroshetz has been denied. I guess the NIH_leadership™ needed another position to fill with their time-tested recruitment process.

So I guess we got AD solved then, right? www.cell.com/cell-reports...

"If really good, would you like me to leave the Presidency in order to make “hosting” a full time job?" Yes, sir! You will be the greatest host of the Trump-Kennedy Center Honors the world has ever seen! Only Trump can do this job! Thank you for your attention to this matter. x.com/realDonaldTr...

And ended it with: “merry f*ckin Christmas, you ungrateful biatchez!”

THE SUN IS OUT 🌞

We can't work with foreign collaborators, but they can send money to a foreign PI to conduct an ethically questionable study in a vulnerable population in another foreign country? This is what corruption looks like.

Tule fog has occupied the skies of California's Central Valley for over three weeks.

Local neuronal ensembles that co-reactivate across regions during sleep are preferentially stabilized www.jneurosci.org/content/jneu...

Hmmh. A hippocampal ‘sharp-wave sleep’ state that is dissociable from cortical sleep www.nature.com/articles/s41...

Control group should have been given apricots. coloproctol.org/journal/view...

Science says the avocado tree needs a shade net. www.mdpi.com/2223-7747/14...

New study results indicate that lifestyle changes can protect aging brains. The U.S. POINTER study tested whether a structured, healthy lifestyle program could protect cognitive function in at-risk older adults. The answer is YES. Explore this news and more from #CTAD2025: https://bit.ly/4pTAgoa

Is glymphatic clearance the secret to restorative sleep? academic.oup.com/brain/advanc...

Orexin-A and Circadian Disruption in Alzheimer’s Disease: Implications for Amyloid-Beta Pathology link.springer.com/article/10.1...

We wrote a couple things about the locus coeruleus... www.frontiersin.org/journals/agi...

"Restoring native landscapes, even in areas where only small spaces are available such as hedgerows, roadsides, and backyards, has great potential for increasing the amount of suitable habitat for butterflies and other insects (30)." Native wildflowers are easy to sow and maintain, help fight weeds

A new article from Jordan Cook in our lab and Qijun Tang in the Hattar lab: best practices in long-term fiber photometry recording. We argue that the field needs a standardized framework for experiments and analysis. academic.oup.com/pnasnexus/ad...

"Here, we explore human receptors responsive to molecules displaying in vivo oscillatory patterns and identify melatonin receptor 1A (MTNR1A) as a promising molecular sensor to trigger transgene expression." rdcu.be/eRnoo

Characterization of locus coeruleus neuronal properties with aging in two mouse models of tauopathy journals.sagepub.com/doi/10.1177/...

This is the cabinet where we keep Ted’s dry food. Conditioned place preference?

#SfN25 attendees - make sure to head to the posters when you get to the meeting on Saturday afternoon (V7-V11: Gretchen, Megan, Margaret, Louisa, Bella) and Sunday morning (KK17: Micaela) to hear about our work. We're printing the posters now and they look rad.

Excellent review article by @grandner.bsky.social about A-β. Finishes up a lot of thoughts that I had only begun to ponder. journals.sagepub.com/doi/10.1177/...

Associations between sleep duration, insomnia, depression, anxiety and registry‐based school grades: A longitudinal study among high‐school students - Evanger - 2025 - Journal of Sleep Research - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

International recommendations for sleep and circadian research in aging and Alzheimer's disease: A Delphi consensus study alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Welp, antifa did it. They finally burned Portland to the ground. Nothing but smoke left.

My co-authors have yet to move to Bluesky, so I'm pleased to announce our latest work has just been published in @nature.com Neuroscience. Amazing work led by Junheng Li, revealing that falling asleep follows a predictable bifurcation pattern #neuroskyence #sleep www.nature.com/articles/s41...

West Jamaica... youtu.be/a_i66vtoySQ?...

From a crewmember on yesterday's Teal 74 mission into now-Category 5 Hurricane #Melissa. As clear of an eye as you will see in the Atlantic basin.

The UC Regents finally released the “settlement agreement” the Trump administration proposed in August. It’s a doozy. UC alumni, faculty, staff, students, parents, donors—and all citizens of California: Now is the time to let the UC Regents know you do not want them to sign this bad deal.

Now let me welcome everybody to the Wilr Wild West. A state that’s untouchable like Eliot Ness.

Construction of the new ball room is coming along nicely at the White House.

Whoa! A chance to watch the glymphatic system, perchance?

ka-blammed? LOL! "In 1980, he ka-blammed the old Bonwit Teller building on Fifth Avenue in Manhattan so that he could raise up Trump Tower."

I suppose their next excuse is it’s an exit hardly anyone ever uses…?

Newsom was right to close down I-5. The video Trump posted shows he wanted something like this to happen, or at least show he could make it so. We are already in secession territory with this.

Receptor-specific noradrenergic modulation of oscillatory dynamics during non-rapid eye movement sleep in adult male rats www.sciencedirect.com/science/arti...

Trump: "I'm going to be strongly recommending at the request of govt officials, which is always nice, that you start looking at San Francisco. I think we can make San Francisco -- one of our great cities 10 years ago, 15 years ago, and now it's a mess."

jeebus, he's going to invade San Francisco next.

I'm so glad that the pandemic finally made us figure out that we can appear for the first day of jury duty selection remotely. With the dogs and everything else, that would have been difficult to do in person tomorrow morning.

Couch. People from PDX will understand.

“A second inflatable frog has now been spotted wiggling through Portland.”

Yep. He’s right. No stores in Portland anymore. I can only eat the food that grows in my garden. And I sew all my own clothing. It’s rough here. Or….maybe grandpa’s dementia is getting the best of him

If their bloc attire looks like it’s brand new from Lululemon, that’s a huge clue.

My brain is boggling at how scientists are still finding clusters of neurons that they didn't know about before. In the parabrachial nucleus, no less. In my book I described the PBN as the fusebox in the basement #neuroscience

Volkswagen gekauft, kein Volk drin. Das ist Betrug. #VeggieWurst

Intelligence officials confirm that aluminum tubes used to produce nuclear weapons have been found in Portland.

The Role of Sleep in Dementia Prevention: Building the Case for Causality academic.oup.com/sleep/advanc...

Today is World #AlzheimersDay A note of optimism @science.org www.science.org/doi/10.1126/...