Therapeutic Use of Integrin Signaling in Melanoma Cells: Physical Link with the Extracellular Matrix (ECM) www.mdpi.com/2072-6694/17...

Why engage youth in science? 🧑‍🎓 Hear from the directors and special guests – #CERN Director-General Fabiola Gianotti, architect Renzo Piano, and John Elkann, President of Fondazione Agnelli – on why it is important to get the young generation interested in science.

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.678028 #proteindesign

“The integrin odyssey – a journey full of fundamental discoveries” by Fässler and Sonnenberg in @jcellsci.bsky.social, worth a read! journals.biologists.com/jcs/article/...

Kowalczyk et al. provide a historical perspective on the discovery of #desmosomes and how imaging technologies have advanced our understanding of this adhesive intercellular junction. rupress.org/jcb/article/... 📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...

When you had quals & published your first paper!✨behind✨SO PROUD to share we published our first piece of the CasL story!! journals.biologists.com/jcs/article/... The scaffold protein CasL restrains membrane blebbing and promotes T cell migration | Journal of Cell Science | The Company of Biologists

BaR-based cryo-EM of platelet integrin αIIbβ3 pubmed.ncbi.nlm.nih.gov/40938611/ #cryoem

Have you applied for the Instruct-ERIC Industry Co-fund R&D call? Get up to €30,000 matched by industrial partners for your technology development project in structural biology. Find out more about the call and apply here - instruct-eric.org/submit-call/...

Basement membranes at a glance journals.biologists.com/jcs/article/...

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

Just a few days left to register for the next Diamond/CCP4 Data Collection and Structure Solution Workshop! This is an excellent training course delivered at a unique location and close to the most wonderful time of the year. It also has LOTS of tutors per student! www.ccp4.ac.uk/schools/DLS-...

🎉It's finally out! Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling | Science Advances www.science.org/doi/10.1126/... - Amazing work Emilie, Ioannis and all co-authors and collaborators!

Honored to receive the 2026 DeLano Award from @asbmb.bsky.social. Warren wrote PyMOL which I spend several hours a day with -- a hero for open & accessible software. Helen Berman, another of my heroes, nominated me (with help from Ruth Nussinov & Janet Thornton), three women I admire tremendously.

Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation pubmed.ncbi.nlm.nih.gov/40890113/ #cryoem

M​. Carmen Salinas-Garcia et al.: Understanding domain swapping in the c-Src SH3 domain through hinge-loop mutagenesis ##SH3Domains##DDomainSwapping##HingeLoop@ualmeria@canalugr...##IUCrhttps://journals.iucr.org/paper?S2059798325006977

Excited to share our new preprint in @biorxiv-neursci.bsky.social "Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains" Instead of a 🧵 the paper is summarised in this video. www.biorxiv.org/content/10.1...

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

📰 New paper out in 'The FEBS Journal'! This study by Mónica Balsera, from #IRNASA-CSIC, reveals a novel mechanism in cyanobacteria. 🔗 febs.onlinelibrary.wiley.com/doi/10.1111/... #Cyanobacteria #RedoxBiology #StructuralBiology #Microbiology #Biochemistry

Why would anyone want to be a scientist? Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...

Platelets sequester and harbor cell-free tumor DNA, which could enhance our ability to make early, microscopic diagnosis of cancer @science.org science.org/doi/10.1126/... science.org/doi/10.1126/...

Structural basis of MPL activation by thrombopoietin pubmed.ncbi.nlm.nih.gov/40766813/ #cryoem

We are delighted to announce that Instruct has added a Centre in Germany, and expanded its existing Centre in Spain with new facilities, services, and technologies! See the list below - all new services will be available for funded access soon! Watch this space! instruct-eric.org/news/new-ger...

The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM. Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur... #LMBNews 🧪🔬

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out: www.sciencedirect.com/science/arti...

In this Opinion article, Yu-Ming Lu discusses multiple important studies on microtubule acetylation with the aim of clarifying the actual role of α-tubulin K40 acetylation, a major tubulin post-translational modification. journals.biologists.com/jcs/article/...

This is amazing, art work based on The MeshCODE Theory. www.davinci-project.com/collection/a... Thanks Nash Cruz and Mireya Vazquez-Prada

Very excited about our latest all-atom generative model proteina, check out the project page (research.nvidia.com/labs/genair/...) and stay tuned for the code release soon!

Paumier, Sauvanet, Gigant @mikicalab.bsky.social highlight work from Muñoz-Hernández, Xu et al @mike-wieczorek.bsky.social (rupress.org/jcb/article/...) which describes new insight into the means by which NEDD1 protein recruits the γ-TuRC to microtubule-organizing centers rupress.org/jcb/article/...

A tribute to Pedro Cuatrecasas, the Spaniard who (whilst working in the US) co-invented affinity chromatography.

NIH Director say journals "bully scientists into paying large fees". No. Academia is a prestige economy in which scientific leadership chose to make journals the currency & Gold OA was deemed 'the way'. Publishers just cashed in; you don't have to pay $10K www.insidehighered.com/news/governm...

🏆 Congrats to Michal Dibus for winning the daily poster prize from FEBS Open Bio today with his poster "Tensin 1 phase separation in regulation of integrin adhesion dynamics"👏 @midibu.bsky.social @ivaskalab.bsky.social #FEBS2025 #FEBSCongress2025

In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET. The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.

📰 El Profesor de Investigación del CNB-CSIC José María Carazo recibió ayer el Premio Manuel Rico – BRUKER de la Sociedad de Biofísica de España por su destacada trayectoria en biofísica estructural. 🔗 Lee la noticia completa en nuestra web: bit.ly/PremioMR25 @csic.es @instructi2pc.bsky.social

Together with Toyin Asojo, Graham Chakafana and Craig Smith, we have recently edited a focused issue on 'Empowering education through structural genomics', featuring the work of both undergrads and high school students – watch Toyin interview Aruesha, Aryana & Raymond www.youtube.com/watch?v=KJkN...

So proud of the smashing success of the International Course in Biophysics co-organized with my @berkeleymcb.bsky.social colleague Carlos Bustamante and University of Salamanca @usaloficial.bsky.social biophysal.org Course ends with a Keynote from Nobel Laureate Richard Henderson🥇

I made a little doodle this weekend showing how I felt when I saw my first Titan Krios in person. That was quite a few years ago now, amazing how much has changed in the cryoEM field since then.

Wish I could be there! An unmissable chance to hear Richard Henderson speak in the magical setting of Fonseca, Salamanca. ❄️⚡🔬

📢 Keynote of BioPhySal course by Prof Richard Henderson 📍University of Salamanca, Hospederia Fonseca 📆Saturday, July 5th 🕗7:30pm Free entrance, Open to the public @usaloficial.bsky.social ‬ ‬ @ciccancer.bsky.social ‬ @interibfg.bsky.social ‬ @cnb-csic.bsky.social ‬ LUMES-USAL

Fiore, V. F., Almagro, J., & Fuchs, E. (2025). Shaping epithelial tissues by stem cell mechanics in development and cancer. Nature reviews. Molecular cell biology, 26(6), 442–455. #EpithelialMechanicsReview buff.ly/wS0nzdW

#IQFSeminar #IQFSeminario Understanding bacterial immune systems and its allosteric mechanisms: From basics to therapies 🗣️Guillermo Montoya 🗓️Friday, 4 July 🕛 12:00 📍#iqf

ONI has landed in Salamanca 🇪🇸 Excited to be part of the first-ever #BioPhySAL2025 at the University of Salamanca! Come by our table to see how super-resolution is transforming single-molecule imaging. #SuperResolution #Microscopy #ONIImaging #Biophysics #StructuralBiology

We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design! github.com/martinpacesa...

- A postdoc to work on cancer extravasation (4-year project). - A postdoc help in completing Filopodia-related lab projects (2-year). - Multiple Marie Curie postdoc positions that will open in the fall. - We will open a 5-year position to cover my teaching (70% research and 30% teaching).

UCSF ChimeraX version 1.10 has been released! www.rbvi.ucsf.edu/chimerax/dow...

structure prediction is not science if not experimentally validated. period

CryoDRGN-AI: neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets pubmed.ncbi.nlm.nih.gov/40571741/ #cryoem

¡Enhorabuena a todo el equipo que ha hecho posible que el máster “Biología y Clínica del Cáncer” haya sido una vez más reconocido por El Mundo como el segundo mejor de España en el área de biociencias! Más información www.elmundo.es/especiales/m...

This Sunday, June 29, @usaloficial.bsky.social will host a biophysics symposium featuring top-tier speakers. The event is aimed at university students and open to the general public. One of the talks will be given by Eva Nogales @nogaleslab.bsky.social JAE-Chair of @csic.es at the #CNB_CSIC.

Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages www.cell.com/developmenta...