E continuo sem saber falar alemão 😁

I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker. The miracle has a problem: It ends when the prescription runs out. Let's look at the data on the "Rebound Effect." 🧵

Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials novonordisk.com/content/nnco...

Eu gostaria de lembrar aos colegas anti-vacina que estão apagando suas postagens às pressas da seguinte máxima de Hipócrates: “O print é eterno.”

visual abstract of the trial and results

Quero falar sobre a meta-análise de Dieta Cetogênica na Depressão e na Ansiedade que saiu no @JAMAPsych porque sei que amanhã a PICARETOSFERA inteira vai repercutir e vocês precisam saber o significado desses achados. Segue o fio 🧵. jamanetwork.com/journals/jam...

This is a fascinating story. A Lebanese team published a study showing massive benefits for apple cider vinegar in 2024. People immediately noticed it was problematic, and complained. BMJ asked the authors for the data, and they sent it through. The study has just been retracted and WOW 1/n

New piece out - do soft drinks give you depression? Probably not. The evidence is SUPER weak. gidmk.substack.com/p/soft-drink...

10/n Regardless, all of this fuss and noise about soft drinks and depression comes from a cross-sectional study that only assessed soft drink consumption at one time point and did not follow-up patients at all. Which is absurd.

4/n This is straightforwardly meaningless scientifically. It was a cross-sectional survey of food consumption with some gut microbiome assessment thrown in. According to their methods, the only covariates included in the logistic model here were age and sex.

Science can be such a headache sometimes. This study has hit the headlines because the authors claim that it shows that soft drinks cause people to be depressed by negatively impacting their gut microbiome. Several BIG issues with this 1/n

Como escrevi na semana passada, esse estudo altamente problemático jamais permitiria sugerir que adoçantes em geral sejam deletérios para o cérebro, muito menos adoçantes específicos. A reprodução totalmente acrítica pela mídia é algo que precisa ser repensado

Groundbreaking! @gidmk.bsky.social and @slate.com prove that you can cover an academic study by actually *reading* it, not just regurgitating every breathless bullet point from the press release... This is what science journalism should look like 👇 slate.com/technology/2...

We've all had this conversation before: "Dude, we both agree this is red... but how do I know what I see as red is what you see as red? Maybe you see red as I see blue." Mind blown lol. But we finally have some research that sheds light (and color) on the issue. (Thread)

O artigo sobre adoçantes e declínio cognitivo, além dos problemas que já citei ontem aqui e no último episódio do podcast Comida sem Filtro, está repleto de erros estatísticos, se vê nesse fio

It’s really worrying that it takes a political scientist to point out all these irregularities in a paper that is picked up to such an extent by the press — reviewers, science editors, anyone listening? Anyone bothered to ask for the underlying data & code?

1/ 👉 Headlines are spreading about a new study (neurology.org/doi/10.1212/...) claiming that 7 artificial sweeteners are linked to accelerated cognitive decline. Most headlines use causal language and scary numbers. But the study is VERY problematic. 🧵

Man, I should really stop opening cans of Pepsi Max by slamming them into my forehead

1/ 👉 Proliferam manchetes sobre um novo estudo (neurology.org/doi/10.1212/...) que alega que 7 adoçantes artificiais estão associados com declínio cognitivo acelerado. 📰 Quase todas usam linguagem causal e números assustadores. Mas o estudo é BEM problemático. 🧵

A new expression of concern was published on this randomized clinical trial of cinnamon for diabetes. The study itself has been cited, according to Google, 1,700 times. I first complained about it in 2023, so let me tell you the story of one of the most problematic papers I've come across 1/n

Querem apostar que o Tarcísio vai continuar se humilhando? g1.globo.com/politica/blo...

Editorial do Estadão de hoje. Lembrando que trata-se de um jornal *conservador*. O conservadorismo precisa se distanciar do golpismo e do entreguismo. Ainda há tempo

MAGA / PL / NOVO

youtu.be/KZeIEiBrT_w?... This is SO amazing (nerd alert)

🔥

Excited to announce my new book FOOD INTELLIGENCE coauthored with brilliant journalist @juliabelluz.bsky.social‬! Cutting through the confusion about diet & health, #FoodIntelligence describes the fascinating science of how food both nourishes & harms us. www.penguinrandomhouse.com/books/671334...

A direita brasileira tem agora uma oportunidade *única* de imitar a direita europeia e criar um CORDÃO SANITÁRIO para isolar o extremismo golpista. Não precisa ser petista nem esquerdista. Mas não pode vender o país e rastejar pra salvar Grande Líder. Editorial do Estadão:

Excelente novamente. O Estadão (insuspeito de ser "comunista") sacou que não haverá outra chance melhor de a direita se descolar de vez do bolsonarismo. Vestir-se de verde e amarelo não torna ninguém patriota, como ficou claro nos últimos dias.

Editorial do Estadão de hoje 👏👏👏👏

Some ultraprocessed foods and sugar-sweetened beverages labeled “Not Recommended for Human Consumption” in one state/US for the first time) long after action taken by Australia, Canada, the European Union, and the United Kingdom. katiecouric.com/health/nutri... @katiecouric.bsky.social

📢 Paloma Shemirani, uma jovem de 23 anos, morreu de um tipo de câncer altamente tratável após rejeitar a quimioterapia e seguir um tratamento ineficaz baseado em enemas e sucos de vegetais, defendido por sua mãe negacionista, Kate Shemirani. [+]

The key issue with putting contrarians in power is that their platform is entirely based on arguing against the mainstream. Mainstream public health makes mistakes, but on the aggregate it's pretty solid and evidence-based. If you throw out everything mainstream, you're left with a lot of nonsense.

2 new studies on weight loss 1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam... 2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...

12. Fica a lição: por enquanto, Grok e outras IAs, quando usados para data scraping, tem fornecido dados bem pouco confiáveis e justificativas que não condizem com os fatos. IA deveria ser usada como muleta, jamais como perna.

Nos últimos meses, o uso de IA para corroborar a veracidade de alguma informação ou solicitado dados quantitativos aumentou de forma impressionante em mídias sociais – o que pode parecer bom, mas é preocupante, como vou mostrar com exemplos reais. 🧵

5 truths about losing a lot of weight 1. You need to get into a calorie deficit 2. Lift weights to not lose muscle 3. You don’t need to do cardio, but it may help keep the weight off 4. It’s not going to be easy and you may need medicine to help 5. Food choice matters

E eis que, finalmente, o veranico de maio se foi. Espero por esse dia ❄️ que nem criança espera pelo Natal

The chances that a viral health trend is at least two of: 1. Ineffective 2. Harmful 3. Expensive Is close to 100%. The worst reason to do something for your health is that it's briefly popular on Instagram/Tiktok.

As outras estações que me perdoem, mas o outono é fundamental

I have no interest in defending Prasad, but I think it's worth noting that the U.S.'s position on childhood immunization against COVID-19 is out of step with international guidelines. In Australia, children under 18 are only eligible for COVID-19 vaccines if they are seriously immunocompromised.

Cool new paper from colleagues showing that diabetes rates are a substantial underestimate in Australia and we're probably missing at least 30% of cases (if not more). www.sciencedirect.com/science/arti...

My latest on Medscape covers a recently published study that both traditional media and social media reported as being proof that Splenda increases hunger (and of course as a consequence, increases weight). Sounds scary. Unless you actually read the paper 🧵

Como de hábito, é tudo hype

If you're keeping track of the long list of things this admin's done that flies in the face of MAHA, censoring and ultimately losing the top intramural nutrition scientist studying food processing and health is definitely towards the top.

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.

The first randomized trial comparing fecal occult blood testing (every other year) testing and (one-time) colonoscopy. No significant difference in colon cancer mortality among >56,000 participants www.thelancet.com/journals/lan... @thelancet.bsky.social

@ebrietzke.bsky.social parabéns pelo artigo, Elisa! Aproveite para convencer o seu coautor Chris Palmer a entrar para o Bluesky! pubmed.ncbi.nlm.nih.gov/40117502/