New Pre-Print Alert! Evolving initial conditions: an alternative developmental route to morphological diversity with Shannon Taylor and @jamesehammond.bsky.social www.biorxiv.org/content/10.6...

I am giving a talk this Tuesday at @Harvard Neural Development Club about how minimal memory of spatial patterning confers flexible neuronal fates, thanks to @yichiahuang.bsky.social for the invitation. Thrilled to meet folks in Boston. Food provided. Apr 21, 5:30 PM, Warren Alpert 236

I don’t regret doing a postdoc in Boston but a little foresight into the weather when experiment planning MAY have saved me some trouble 🥶 Celebrating a successful day in lab thanks to my amazing labmates @cynthiamoncadareid.bsky.social @yichiahuang.bsky.social 🫶 #SequencingScienceSisters

🎵WHY DO ENHANCER! SUDDENLY APPEAR! EVERY TIME! THEY ARE NEAR!?! JUST LIKE ME! THEY LONG TO BE! CLOSE TO POLII! 🎵 www.nature.com/articles/s41...

🎓 After 5 years, the heart of my thesis is finally live! Pluripotent Stem Cell Plasticity is Sculpted by a Slit‑Independent Robo Pathway in a Regenerative Animal 🧬🧠 Read it here 👉https://www.biorxiv.org/content/10.1101/2025.04.14.648795v1 More details in the🧵👇

In this Review, Mätlik et al. discuss the influence of histone bivalency (activating H3K4me3 + repressive H3K27me3) on neuronal development and maturation. #openaccess Learn more here: ➡️ tinyurl.com/gd352306

👇👇👇 New preprint dropped! Where we dive deep into the factors that restrict pluripotent stem cells to make the RIGHT cell types in the RIGHT place in planarians. Many surprises in this very exciting story. @kuangtse.bsky.social

We made it to the cover! :)

Happy National Learn About Butterflies Day! 🦋 MBL Director Nipam Patel showed students from The Hockaday School and Wareham High School his collection this week! 📷: An emerald swallowtail butterfly. Credit: Nipam Patel 📷: Patel teaches Hockaday students. Credit: Alex Megerle

In honor of #WorldHearingDay, explore the focus of the Piotrowski Lab – understanding the development & regeneration of the #zebrafish lateral line & the potential applications for promoting mammalian hair cell #regeneration to restore #hearingloss or #deafness.

Perfect way to start the new lab and the new year! Excited to talk about octopus cells with everyone

Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org

Ok people. I’m drawing silhouettes this afternoon. If you have a paper coming up and you are in need of a #silhouette please let me know and I will have it ready today. As always I upload all my silhouettes to phylopic.org I also have tutorials on how to put a silhouette in a plot in R.

To mark the 40th year since the homeobox discovery, we've commissioned a series of articles from leaders in the field demonstrating the impact of the discovery on different disciplines. Check out the full collection: https://journals.biologists.com/dev/collection/10249/40-years-of-the-homeobox

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...

Change is rarely easy, but the right changes are worth it. As the year comes to a close, we’re showcasing some research and publishing highlights from the year with the hashtag #12DaysOfeLife Follow along over the next 12 days or check out our blog now! https://buff.ly/3Dhn21z

Our latest: how to generate the notochord "Timely TGFβ signalling inhibition induces notochord" A thread: www.nature.com/articles/s41...

My first post on bluesky!! Excited to see my PhD work featured on the cover of NCB @naturecellbiology.bsky.social December issue! This image shows a gorgeous #zebrafish embryo undergoing cell division (the green cells with condensed chromatin)—a fundamental process we study in development. 🧵1/2

In one year, I genetically engineered the boring Arabidopsis into a beautiful ornamental flower 🧬🌹 Here is how and why I gave this model organism a visual upgrade 🧵(1/7)

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

We are interested in all aspects globally connecting the neural crest to evolution, biomedicine and specific sub-field of developmental biology. In this study we show the role of motor circuits in shaping neural crest-derived sympathetic nervous system: www.nature.com/articles/s41...

Identification and developmental profiling of microRNAs in the acoel worm Hofstenia miamia https://www.biorxiv.org/content/10.1101/2024.12.01.626237v1

Welcome to the #devbiolwriteclub Bluesky Boot Camp! I’ll be posting here regularly with thoughts and exercises to help scientists become better writers. Let’s start by managing expectations: I will NOT help you write better. I WILL help you become a better writer. 🧵 1/10

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

Excited to share work that @ceriweber.bsky.social started and drove in my lab. Tails!! We know a lot about limb bone growth, but vertebrae have completely different embryonic and evolutionary origins. What controls growth and proportion in the vertebral skeleton? www.biorxiv.org/content/10.1...

"It's a worm's world" a lovely article by Maddy Frank about our lab's work! biology.wustl.edu/news/its-wor...

REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers. New preprint from a collaboration led by Grace Bower and Evgeny Kvon. doi.org/10.1101/2024...

Please read and share this ⬇️ journals.biologists.com/dev/article/...

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases https://www.biorxiv.org/content/10.1101/2024.11.15.623687v1

*Highly recommend* a simple plug in called Color Oracle: colororacle.org It’s a free color blindness simulator. Just one click, it shows you in real time what people with common color vision impairments will see on your screen. I use it to doublecheck everything! #microscopy #figures #academicsky