Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! www.biorxiv.org/content/10.1...

📢 @bayraktarlab.bsky.social & colabs at @sangerinstitute.bsky.social are assembling the @opentargets.org funded Neuroimmune Team 🧠🧬-Leverage AI to uncover neurodegeneration Tech Spec: sanger.wd103.myworkdayjobs.com/en-US/Wellco... Postdoc AI: sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Very excited to see this work comes out ad preprint! An elegant strategy discovering novel recessive signals in Exome sequencing dataset of the British South Asian population 🧬 #bioinformatics #exome #DNA #datascience #genomics #genetics

Analyzing your single-cell data by mapping to a reference atlas? Then how do you know the mapping actually worked, and you’re not analyzing mapping-induced artifacts? We developed mapQC, a mapping evaluation tool www.biorxiv.org/content/10.1... from the ‪@fabiantheis lab. Let’s dive in🧵

Amazing work by the GBM-SPACE team atlassing one of the deadliest cancers #glioblastoma at multimodality, & coupled the elegant scDORI framework. These studies reveal a high-resolution spatiotemporal cell trajectory from tumour heterogeneity & plasticity at both cellular and molecular levels

Ever wondered what a snapshot of single-cell/spatial dataset can reveal? scCellFie - a scalable tool that goes beyond gene expression, making metabolic analysis possible 3-2-1, Say GENES 🤳 PREPRINT: doi.org/10.1101/2025... DOWNLOAD: sccellfie.readthedocs.io #DataScience #Bioinformatics #Spatial

We are delighted to announce a new collaboration between HCA and @UNESCO.org to help advance open science, global capacity and ethical frameworks to deliver the benefits of genomics at a global scale. www.humancellatlas.org/news/the-hum...

Absolutely over the moon to share our COVID-19 study is now featured on @naturecomms.bsky.social Editors’ Highlights for Microbiology & Infectious Diseases! Huge thanks to Sonja Schmid for choosing our work as one of the 50 BEST papers in this field. 💡Check it out: www.nature.com/collections/...

If you have experience in sc/spatial transcriptomics with an interest in microbes....come and join our team as a computational postdoc: sanger.wd103.myworkdayjobs.com/WellcomeSang... Incredibly exciting datasets on host-microbe interactions in the lung. Pls RT and reach out if you are interested.

Thrilled to share our new @naturecomms.bsky.social study with @sam-n-barnett.bsky.social on early vs late #COVID19 lung damage 🫁. Using single-cell & histopathology-informed #SpatialTranscriptomics, we uncovered key biomarkers & immune patterns. Thanks to collaborators, UKCIC & @humancellatlas.org

Absolutely Amazing!!

It was a pleasure to give a talk at the #HCA2024Asia @humancellatlas.org meeting. I really enjoyed catching up with some @sangerinstitute.bsky.social alumni and had some fascinating discussions with amazing scientists!! #HumanCellAtlas #Neuroscience #SingleCell #Bioinformatics

The integrated transcriptomic cell atlas of human neural #organoids, Barbara Treutlein's lab, @fabiantheis.bsky.social @graycamplab.bsky.social @sergiuppasca.bsky.social @giorgiaquadrato.bsky.social and colleagues: www.nature.com/articles/s41...