Valerio Sorichetti
@vsorichetti.bsky.social
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📥 406
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Senior bioinformatician / computational scientist in the Gerlich Lab at IMBA (Vienna Biocenter).
reposted by
Valerio Sorichetti
Max Spicer
about 1 month ago
Chuffed to have defended my PhD thesis! Big thanks to
@danielgerlich.bsky.social
for all his support and guidance; and to the wonderful
@gerlichlab.bsky.social
,
@imbavienna.bsky.social
&
@viennabiocenter.bsky.social
for being an incredible scientific home these past few years. On to the next :)
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Valerio Sorichetti
Sonja-Verena Albers
about 2 months ago
New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.05.19.726155v1
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I'm happy to share that I have started a new position in the Gerlich Lab (
@gerlichlab.bsky.social
) at IMBA (
@imbavienna.bsky.social
) as Senior Bioinformatician. Looking forward to contributing to the great science developed in the group! 😊🧬
2 months ago
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reposted by
Valerio Sorichetti
Gerlich Lab
2 months ago
New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗
doi.org/10.64898/2026.05.02.722390
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https://doi.org/10.64898/2026.05.02.722390
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Amazing colloquium talk by Christa Schleper from
@univie.ac.at
@archaea-vienna.bsky.social
on how archaea use protrusion to crawl on surfaces!
#archaea
#loki
@istaresearch.bsky.social
7 months ago
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Valerio Sorichetti
Archaea Biology Vienna
7 months ago
Asgard on the move ! Watch our videos!
Biorxiv.org/content/10.1101/2025.11.30.690169v1
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Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota)
Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion, and spatially organized signalling pathways1–3. Asgard archaea (phylum Promethearchae...
https://Biorxiv.org/content/10.1101/2025.11.30.690169v1
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Something I was recently discussing with some colleagues: is the work of computational scientists closer to the one of experimentalists or to the one of theorists working on analytical models?
9 months ago
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I tried it -- very impressive! A caveat, however -- it might make you feel as if your published papers aren't as good as you thought 😅
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9 months ago
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Our paper on chromosome segregation in the archaeon Sulfolobus Acidocaldarius has been published in PNAS! This has been a great collaboration with
@joeparham19.bsky.social
and the rest of
@buzzbaum.bsky.social
's team. Stay tuned for more to come!😉
@istaresearch.bsky.social
doi.org/10.1073/pnas...
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Temporal and spatial coordination of DNA segregation and cell division in an archaeon | PNAS
Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segre...
https://doi.org/10.1073/pnas.2513939122
9 months ago
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Grateful for this opportunity of taking part in the 9th International Soft Matter Conference in beautiful Crete and presenting my research! It's been a great week of science, stimulating discussions and great food in a beautiful scenery 😊🏖️
9 months ago
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It has been a great workshop! Thanks to
@romanstano.bsky.social
, Peter, Emanuela and Christos for giving me the opportunity to present my work :)
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10 months ago
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reposted by
Valerio Sorichetti
David Brückner
10 months ago
Super excited that our group will be supported by an ERC Starting Grant! In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions. We'll have PhD and Postdoc positions available, please get in touch if interested!
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Our paper on the nonequilibrium mechanics and remodelling of collagen-IV networks is finally out on
@prxlife.bsky.social
! It has been a long and exciting scientific journey, led by
@billiemeadowcroft.bsky.social
!
@ivnpla.bsky.social
@yanlanmao.bsky.social
journals.aps.org/prxlife/abst...
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Nonequilibrium Remodeling of Collagen IV Networks in Silico
Active bond remodeling enables collagen IV networks to have a range of responses to strain while maintaining their mechanical integrity.
https://journals.aps.org/prxlife/abstract/10.1103/gdd5-rnh7
10 months ago
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Sally Rooney books are kinda neat until you read a couple and realize that all the plots and characters are exactly the same...
11 months ago
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Sass de Putia, Dolomites!
11 months ago
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The Dolomites really are a special place. Very lucky to have had so many days of great weather! ⛰️🥾
11 months ago
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A stambecco (ibex) with her baby 🐐
11 months ago
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reposted by
Valerio Sorichetti
Institute of Molecular Biotechnology
11 months ago
Scientific curiosity at IMBA inspired this year's art series, created from research images. Today's kaleidoscope is based on an artistic rendering of the spiral staircase model of the mitotic chromosome, produced by the Goloborodko lab using new tools for analyzing 3D chromosome structure.
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And it's finally published on
@prxlife.bsky.social
! Thanks to Paul Robin (Hannezo lab) ,
@ivnpla.bsky.social
(Šaric lab),
@aharmendariz.bsky.social
(Cuylen lab). It's been a very stimulating and highly satisfying journey! 🧬
journals.aps.org/prxlife/abst...
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11 months ago
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Sass dla Crusc in the Dolomites 😊
11 months ago
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So satisfying when the last round of proofs for your paper comes back the day before you leave for vacation! 😊
11 months ago
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Is it just me or Google search results got significantly worse recently?
12 months ago
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reposted by
Valerio Sorichetti
Anton Goloborodko
12 months ago
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
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Wow!! This is super cool!
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about 1 year ago
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reposted by
Valerio Sorichetti
Randall Munroe
about 1 year ago
Good Science
xkcd.com/3101/
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First time it happens to me: the book I'm reading (Thinking, Fast and Slow by Daniel Kahneman) is missing 49 pages 😅
about 1 year ago
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With the explosion in popularity of Gen AI tools, I wonder if we will go back to having more oral exams in schools and universities. Which in Italy we already do, because we haven't really updated our teaching methods in like 50 years... 😅
about 1 year ago
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@buzzbaum.bsky.social
@joeparham19.bsky.social
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about 1 year ago
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How do archaea partition their genome just at the right time before cell division? Check out this new
#preprint
if you want to know! A great collaboration with Joe and the
@buzzbaum.bsky.social
lab! 🦠🧬
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about 1 year ago
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The workshop on polymers and biomolecular condensates in Meißen was great! I've learnt a lot and met some great people, and got to visit the beautiful Meißen and Dresden! Thanks to the organizers
@albertilab-tud.bsky.social
, Arash and Jens!
about 1 year ago
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Meißen at night! 🤩
about 1 year ago
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Very engaging talk by Daniel Bonn on rheology and phase separation of active (and in some cases drunk) worms! 🪱🪱🪱
about 1 year ago
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Happy Star Wars day!
about 1 year ago
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reposted by
Valerio Sorichetti
Tom Gauld
about 1 year ago
A recent
@newscientist.com
cartoon
#fungi
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I love papers like this 🌹 Discovering complexity in mundane things!
www.science.org/doi/10.1126/...
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Geometrically frustrated rose petals
Growth and form are deeply interconnected, in a manner often mediated by mechanical instabilities arising from geometric incompatibilities. Although Gauss incompatibility has long been recognized as t...
https://www.science.org/doi/10.1126/science.adt0672
about 1 year ago
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reposted by
Valerio Sorichetti
Itai Yanai
over 1 year ago
🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
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reposted by
Valerio Sorichetti
Mark Hamill
over 1 year ago
I remember it being unpleasant & a lot less fudge-y.
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Super cool experiments by Alfredo and the team!! The laser ablation one in particular is very clever. Definitely check this out if you're interested in the cytoskeleton or active matter in general 🙌
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over 1 year ago
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Made Mapo Tofu (vegetarian version, with shiittake mushrooms instead of meat) for the first time yesterday. Pretty happy with the results! 😋
over 1 year ago
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Typical researcher
over 1 year ago
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reposted by
Valerio Sorichetti
Morgan Tingley
over 1 year ago
The insanity of being a fire ecologist in the epicenter of a major fire event, bags packed and ready to evacuate, watching active fire from my window, while taking media requests and explaining to the public, for the 100,000th time how climate change is largely responsible for this
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This show was incredible
over 1 year ago
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Cacio e Pepe is a notoriously difficult pasta recipe. Luckily, we can find the perfect recipe using science! 🍝🧑🔬 Most importantly, be sure to avoid the "mozzarella phase"! Great article by
@vicioms.bsky.social
and colleagues 😁
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over 1 year ago
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The New Year's Eve fireworks in Naples 🎇🎆
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over 1 year ago
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reposted by
Valerio Sorichetti
Oded Rechavi
over 1 year ago
When you get an email from a post doc CCing the big shot boss
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View of Naples from Castel Sant'Elmo 🏰
over 1 year ago
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reposted by
Valerio Sorichetti
Alfredo Sciortino
over 1 year ago
It's the time of the year when I make a Christmas themed experiment to celebrate another year gone by: this year, a micropatterned branched actin network with myosin, aka a Christmarp(2/3) tree, doing weird stuff. Happy holidays Bluesky! 🥳🥳🥳
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reposted by
Valerio Sorichetti
bioRxiv Biophysics
over 1 year ago
The mitotic chromosome periphery: a fluid coat that mediates chromosome mechanics
https://www.biorxiv.org/content/10.1101/2024.12.21.628209v1
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reposted by
Valerio Sorichetti
Alex Klotz
over 1 year ago
Davide isn't here yet so here's a nice review he just wrote on kinetoplast biophysics
academic.oup.com/nar/advance-...
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Kinetoplast DNA: a polymer physicist’s topological Olympic dream
Abstract. All life forms are miraculous, but some are more inexplicable than others. Trypanosomes are by far one of the most puzzling organisms on Earth: t
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1206/7925237
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Loop extruders induce twist on DNA strands! Very cool!
add a skeleton here at some point
over 1 year ago
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