Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀 Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function now revised and journal accepted at www.science.org/doi/10.1126/... 🧵👇

Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social. www.cell.com/cell-reports... Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12

Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!

I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)

“Our findings suggest the existence of tens of thousands of enhancers that remain undiscovered by currently available chromatin data, underscoring the continued need for expanding resources for enhancer discovery.” Great paper and very important finding - many congrats Axel & team! 👏👏

Amazing work by @charleneboumendil.bsky.social and her team addressing the crucial role of nuclear pores in chromatin organization. A highly recommended read!

OK, this is wild. In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them. It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*. What the HELL? 1/

Happy to share our collaborative effort showing a temporal decoupling between morphogenesis and transcription during gastruloids self-organization www.biorxiv.org/content/10.1...

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

Hi Bluesky! I made a 3D chromatin starter pack. Let me know if you would like to be added. go.bsky.app/6tTQdqQ

In this review @gracebower.bsky.social & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their targets rely on additional mechanisms to ensure robust gene activation during mammal development. www.sciencedirect.com/science/arti...

REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers. New preprint from a collaboration led by Grace Bower and Evgeny Kvon. doi.org/10.1101/2024...

Hi all, just to say thanks for all the enthusiasm about the #epigenetics, Chromatin and Gene Regulation starter pack. The interface is a bit unreliable so a few people I added got missed off 😬. If you notice this applies to you, just message me and I'll try again. go.bsky.app/TKp9YAn

Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg

Just finished hosting @PengyiYang82 and lab members for an amazing week @IGH_MTP filled with learning about scMultiomics, brainstorming and maybe a drink or 3. So proud to see how far we've come since our postdocs in @Jothi_Lab 🍻

🚨Job offer alert: looking for a friendly and enthusiastic research assistant (IE) to help us understand how enhancer activity is orchestrated during the EMT.🚨 Location: 🌞 Montpellier, France. Duration: up to 3 years. Apply here: tinyurl.com/3dn86pmz Retweets appreciated 🙏🏼