🚨 New publication! A tiny switch with big consequences: PhD student Trinh Phan-Canh reveals in @cp-cellreports.bsky.social that Candida auris shifts between White and Brown phenotypes – a change that impacts both drug resistance and virulence ➡️ tinyurl.com/6f2nm268 @meduniwien.ac.at

White-Brown switching controls phenotypic plasticity and virulence of Candida auris

White-Brown switching controls phenotypic plasticity and virulence of #Candida auris: Cell Reports www.cell.com/cell-reports...

Thrilled to share our latest in @cp-cellreports.bsky.social : White–Brown switching in #Candida #auris is now out! This may be the first comprehensive study of epigenetic switching in #auris, shedding light on clinical variability in virulence and antifungal resistance. Link in comment! 1/n

Has anyone experienced unusually slow performance from the Candida Genome Database this week? #CandidaGenomeDatabase

AlphaFold’s highly accurate structural models transformed protein biology. Nature reports on the efforts to create a similar system for RNA and why it’s a tougher nut to crack. #RNAsky 🧪

A short letter in which I demonstrated that phosphatidylinositol transfer protein Pdr16 is responsible for azole resistance in Candida auris. The upregulation of these proteins may also be involved in resistance to amphotericin B and flucytosine. journals.asm.org/doi/10.1128/...

#TEsky The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition doi.org/10.7554/eLif...

My group @aps-hki.bsky.social is looking for a new postdoc in immunology of fungal infections focusing on vulvovaginal candidiasis. Please contact me for further details in case of interest.

At the very beginning of my PhD, I approached most experiments like a child playing in a garden—exploring with curiosity and excitement. Check it out: Rapid in vitro evolution of flucytosine resistance in Candida auris 1/4

AI for modelling infectious disease epidemics https://www.nature.com/articles/s41586-024-08564-w (read free: https://rdcu.be/eaA6O) 🧬🖥️🧪

As I approach the final stages of my PhD, I find myself overwhelmed by many potential ideas and ambitious projects that come to mind every day. However, it’s time to put a stop to it— I need to go further.

A Collaboration Paper with Philipp: “HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections” www.cell.com/cell-reports...

I’m excited to share our collaborative work focusing on the multiomics landscape of #Aspergillus-Klebsiella interactions, published in #CommunicationsBiology. It was a lot of fun to explore how fungi and bacteria respond to each other. Paper: www.nature.com/articles/s42...

🔑 #fungalevolution Candida auris can generate a pooled population with diverse phenotypes from a single parental strain. PLOS Pathogens: journals.plos.org/plospathogen... #Candidaauris #Candida #infectiousdisease #morphogenesis #climatechange