Mac Shine
@macshine.bsky.social
📤 2984
📥 2329
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Computational Neurobiologist from Sydney, Australia.
https://shine-lab.org
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Mac Shine
Tim Viney
8 days ago
*New preprint from the lab* – “Granularity of thalamic head direction cells”
doi.org/10.1101/2025...
🧠📈 🧪 1/11
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Granularity of thalamic head direction cells
Head direction signaling is fundamental for spatial orientation and navigation. The anterodorsal nucleus of the thalamus (ADn) contains a high density of head direction (HD) cells that process sensori...
https://doi.org/10.1101/2025.09.08.674912
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Paul Middlebrooks
13 days ago
What changes and what stays the same as you scale from single neurons up to local populations of neurons up to whole brains? Michael and Mac
@macshine.bsky.social
on the systems approach to study brains across scales.
braininspired.co/podcast/220/
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Mehrdad Kashefi
17 days ago
Excited to share my latest work with
@jonathanamichaels.bsky.social
@diedrichsenjorn.bsky.social
&
@andpru.bsky.social
! We asked: How does the motor cortex account for arm posture when generating movement? Paper 👉
www.biorxiv.org/content/10.1...
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Compositional neural dynamics during reaching
The complex mechanics of the arm make the neural control of reaching inherently posture dependent. Because previous reaching studies confound reach direction with final posture, it remains unknown how...
https://www.biorxiv.org/content/10.1101/2025.09.04.674069v1
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Claire O'Callaghan
26 days ago
Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level). If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this:
www.cell.com/trends/cogni...
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Paul Middlebrooks
27 days ago
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BI 219 Xaq Pitkow: Principles and Constraints of Cognition
YouTube video by Brain Inspired
https://www.youtube.com/watch?v=ugorctvkCa0
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Mac Shine
Nature Reviews Neuroscience
about 1 month ago
Theoretical neuroscience has room to grow — a Comment article by Ann Kennedy
@antihebbiann.bsky.social
#neuroscience
#neuroskyence
www.nature.com/articles/s41...
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Theoretical neuroscience has room to grow - Nature Reviews Neuroscience
The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine the use of top-down conceptual and...
https://www.nature.com/articles/s41583-025-00965-8?utm_source=bluesky&utm_medium=social_&utm_campaign=nrn
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I need some help from the
#neuroskyence
Bluesky-verse. Anyone know the source of this ~quote from Walter J. Freeman Jr.: "the secrets of the brain are hidden by two of God’s own firewalls: neurobiology and non-linear dynamics". I read it yrs ago but can't seem to find my way back to the source.
about 1 month ago
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Guido Meijer
about 2 months ago
🚨Pre-print alert🚨 We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭 How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
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Serotonin drives choice-independent reconfiguration of distributed neural activity
Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...
https://doi.org/10.1101/2025.08.01.668048
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Christopher Webb
about 2 months ago
🚨 California and Hawaii under tsunami watch after 8.7M quake in Eastern Russia.
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Takuo Matsuzawa
about 2 months ago
Tsunami Warning – 7/30, 9:40am The Tsunami Advisory has been upgraded to a Tsunami Warning. Waves of up to 3m are expected. Those near coastal areas, rivers, or lakes should evacuate to higher ground immediately.
#tsunami
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Robert Sansom
about 2 months ago
The point is, the monkeys making the loudest noise have the smallest balls.
pubmed.ncbi.nlm.nih.gov/26592343/
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Evolutionary trade-off between vocal tract and testes dimensions in howler monkeys - PubMed
Males often face a trade-off between investments in precopulatory and postcopulatory traits [1], particularly when male-male contest competition determines access to mates [2]. To date, studies of pre...
https://pubmed.ncbi.nlm.nih.gov/26592343/
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Mac Shine
Claire Willett
2 months ago
Dem leadership should appoint an official Alt Press Secretary to give briefings after every one that Karoline Leavett does and just break them down lie by lie maybe THAT’S the job we give Colbert 😂
add a skeleton here at some point
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Mac Shine
The Transmitter
2 months ago
An exciting collaboration is underway.
@thetransmitter.bsky.social
is partnering with
@neuromatch.bsky.social
to serve the computational neuroscience community and help connect neuroscientists across all career stages.
www.thetransmitter.org/neuromatch-p...
#neuroskyence
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Mac Shine
shauna
2 months ago
“the kindest person in the room is often the smartest.” JB Pritzker is a mensch.
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PessoaBrain
2 months ago
Prefrontal axons going to lots of places!
doi.org/10.1016/j.ce...
#neuroskyence
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Mac Shine
Andrew Saxe
2 months ago
Pairs well with
www.nature.com/articles/s41...
“Our results indicate that individual V1 neurons do not signal how the actual visual input deviates from the animal’s predictions, as postulated within the predictive coding framework” Thrilling to see a major theory get tested!
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Cooperative thalamocortical circuit mechanism for sensory prediction errors - Nature
Experiments in mice show that a cortico-thalamic circuit generates prediction-error signals in primary visual cortex that amplify visual input that deviates from animals’ expectations.
https://www.nature.com/articles/s41586-024-07851-w
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Mac Shine
Dan Brierley
8 months ago
Really proud to start the year by sharing our new review in
@endosocjournals.bsky.social
on the roles of GLP-1 in eating and obesity treatment, led by superstar postdoc
@laurenjonesucl.bsky.social
!
academic.oup.com/endo/article...
🧪🧠📈
#neuroscience
#neuroskyence
#GLP-1
#obesity
#wegovy
#ozempic
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GLP-1 and the Neurobiology of Eating Control: Recent Advances
Abstract. Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales with body weight, af
https://academic.oup.com/endo/article/166/2/bqae167/7954557
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Mac Shine
Kevin Mitchell
3 months ago
I honestly think we should have a screening system for who gets to have money and influence based on asking "what was Star Wars about?" and "who were the good guys?"
add a skeleton here at some point
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Mac Shine
Nature Reviews Neuroscience
3 months ago
Molecular and functional diversity of the autonomic nervous system — a Review by Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola & Yuki Oka
#neuroscience
#neuroskyence
www.nature.com/articles/s41...
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Molecular and functional diversity of the autonomic nervous system - Nature Reviews Neuroscience
The autonomic nervous system has long been viewed as a simple motor system in brain-to-body signalling. In this review, Wang and colleagues highlight diversity within autonomic neurons and their dynam...
https://www.nature.com/articles/s41583-025-00941-2?utm_source=bluesky&utm_medium=social&utm_campaign=nrn
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Mac Shine
Tim Kietzmann
3 months ago
Exciting new preprint from the lab: “Adopting a human developmental visual diet yields robust, shape-based AI vision”. A most wonderful case where brain inspiration massively improved AI solutions. Work with
@zejinlu.bsky.social
@sushrutthorat.bsky.social
and Radek Cichy
arxiv.org/abs/2507.03168
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https://arxiv.org/abs/2507.03168
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Michelle Greene
3 months ago
🚨 New paper in Journal of Vision! We show that scene affordances—what you can do in a space—shape how we perceive and categorize scenes. This shapes your similarity preferences, predicts your categorization false alarms, and even alters neural representations. 🧵👇 🔗
doi.org/10.1167/jov....
(1/7)
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Function over form: The temporal evolution of affordance-based scene categorization | JOV | ARVO Journals
https://doi.org/10.1167/jov.25.8.10
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Mac Shine
Konrad Kording
3 months ago
Attractors are usually not mechanisms - new blog post:
open.substack.com/pub/kording/...
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Attractors are usually not mechanisms
The mathematical objects can not be. And the "attractor models" have not been established as mechanisms in mammals
https://open.substack.com/pub/kording/p/attractors-are-usually-not-mechanisms?r=ao63f&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
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Valerie Jill Sydnor
3 months ago
How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵
www.nature.com/articles/s41...
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Mac Shine
Ian Phillips
3 months ago
Short new piece on aphantasia just out in TiCS:
www.sciencedirect.com/science/arti...
Key idea: aphantasia often involves a lack of *visual-object* imagery (explaining subjective reports & objective correlates) but selectively spared *spatial* imagery (explaining preserved task performance).
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Spared spatial imagery solves the puzzle of aphantasia
https://www.sciencedirect.com/science/article/pii/S1364661325001147
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Mac Shine
The Transmitter
3 months ago
ICYMI: “For fMRI to meaningfully contribute to progress in neuroscience, we need to develop research programs that link phenomena across levels,” writes Avram Holmes
@avramholmes.bsky.social
.
www.thetransmitter.org/future-of-fm...
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fMRI must break out of its silo
We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.
https://www.thetransmitter.org/future-of-fmri/to-make-a-meaningful-contribution-to-neuroscience-fmri-must-break-out-of-its-silo/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20250626-OHBM-rp-functional-MRI-break-out
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Another great article from
@thetransmitter.bsky.social
and Laura Lewis, who has been working painstakingly over the last few years to help ramp up the spatiotemporal resolution of fMRI so that we can really start to dig into whole-brain signals in vivo.
add a skeleton here at some point
3 months ago
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Mac Shine
The Transmitter
3 months ago
ICYMI: Recent technological advances in functional MRI provide a range of new information about brain physiology. Collaboration between engineers and neuroscientists will help maximize these gains, writes Laura Lewis.
www.thetransmitter.org/human-neurot...
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fMRI can do more than you think
Advances in brain imaging technology provide new and different information about the brain.
https://www.thetransmitter.org/human-neurotechnology/functional-mri-can-do-more-than-you-think/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20250625-OHBM-rp-functional-MRI-can-do-more
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Mac Shine
Ben Fulcher
3 months ago
Paper is here:
arxiv.org/abs/2506.19800
Code is here:
github.com/DynamicsAndN...
If you're interested and at
#OHBM2025
come watch Rishi present his work in the "Modeling and Analysis - Connectivity" workshop on Saturday in the Great Hall; and check out his poster #1440 (on Friday & Saturday)
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Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics
The function and dynamics of the cortex are fundamentally shaped by the specific wiring configurations of its constituent axonal fibers, also known as the connectome. However, many dynamical propertie...
http://arxiv.org/abs/2506.19800
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Mac Shine
Ben Fulcher
3 months ago
New preprint! Why are long-range connectomic interactions in the cortex dominant in shaping dynamics in some experiments but apparently negligible in others? We (w/ R Maran,
@elimuller.bsky.social
) address this question by studying a new hybrid model of cortical dynamics.
arxiv.org/abs/2506.19800
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Russ Poldrack
3 months ago
The Open Science Room has been an exciting space at the OHBM Meeting for many years, but its future is threatened. Please sign this petition to signal your support for preserving a dedicated space for the OSR at future meetings.
ohbm.github.io/osr2025/peti...
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OSR Petition
We are launching a petition to request that OHBM preserves the Open Science Room (OSR) as a dedicated space during the annual meeting for the Open Science community. Although Open Science is a well-ac...
https://ohbm.github.io/osr2025/petition/
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Mac Shine
Thomas Nichols
3 months ago
Useful
#OHBM2024
deep link - Table listing all posters with stand-by times & categories
gmpartners365-my.sharepoint.com/:x:/g/person...
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https://gmpartners365-my.sharepoint.com/:x:/g/personal/kjohnson_humanbrainmapping_org/Ee5yd9J2nrxHlwSVuHfmZpsB7qllf5l684Qk2UFCq9gapA?rtime=Q5A-VLOy3Ug
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Fantastic article from one of the leaders of the burgeoning field or layer-resolved functional MRI. A pleasure to read!
add a skeleton here at some point
3 months ago
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The Transmitter
3 months ago
ICYMI: In this essay for our Future of fMRI series, Laurentius Huber
@layerfmri.bsky.social
explains how new advances in functional MRI could help to connect cells and brain areas at the mesoscopic scale.
#neuroskyence
#OHBM2025
www.thetransmitter.org/future-of-fm...
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Imaging cortical layers to understand brain as network organ
This spatial scale, bridging cells and brain areas, has been overlooked in human brain research. But advances in fMRI technology are changing that.
https://www.thetransmitter.org/future-of-fmri/to-understand-the-brain-as-a-network-organ-we-must-image-cortical-layers/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20250623-OHBM-rp-image-cortical-layers
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Giulia Baracchini
3 months ago
The diversity of methods we use to probe the brain (epistemologies) naturally leads to clashes in our theories of how the brain works (ontologies). So how do we reconcile this divide and grow into a more unified neuroscience? Here is our take:
apertureneuro.org/article/1388...
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Bridging the epistemological divide in neuroscience to improve ontological clarity | Published in Aperture Neuro
By Giulia Baracchini, Eli Muller & 1 more. This perspective highlights the epistemological divide that arises from the wide variety of different experimental approaches... which in turn lead to ontolo...
https://apertureneuro.org/article/138841-bridging-the-epistemological-divide-in-neuroscience-to-improve-ontological-clarity
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Aperture Neuro
3 months ago
🧠 The State of the Brain Special Issue features insights from last year’s keynotes, award winners & committee leaders. 🔗 Explore major findings & themes from 2024:
apertureneuro.org/issue/12560
@arokem.org
@alexfornito.bsky.social
@macshine.bsky.social
@vcalhoun.bsky.social
@misicbata.bsky.social
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Christopher Whyte
4 months ago
New preprint modelling suppression depth in binocular rivalry and continuous flash suppression with Hugh Wilson,
@macshine.bsky.social
, & David Alais
add a skeleton here at some point
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Mac Shine
Russ Poldrack
4 months ago
COS Statement on “Restoring Gold Standard Science” Executive Order
www.cos.io/about/news/c...
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COS Statement on “Restoring Gold Standard Science” Executive Order
The Executive Order issued on May 23, 2025, Restoring Gold Standard Science, references several open science practices championed by COS and the open science and metascience communities more generally...
https://www.cos.io/about/news/cos-statement-on-restoring-gold-standard-science-executive-order
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Mac Shine
PessoaBrain
4 months ago
𝗠𝗮𝘆𝗯𝗲 𝗰𝗼𝗻𝘀𝗰𝗶𝗼𝘂𝘀𝗻𝗲𝘀𝘀 𝗶𝘀 𝗮 𝗯𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗽𝗵𝗲𝗻𝗼𝗺𝗲𝗻𝗼𝗻 𝗮𝗳𝘁𝗲𝗿 𝗮𝗹𝗹 This target paper by Anil Seth should lead to good discussion.
www.cambridge.org/core/journal...
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Lucina Uddin
4 months ago
When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠
www.nature.com/articles/s41...
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The history and future of resting-state functional magnetic resonance imaging - Nature
This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...
https://www.nature.com/articles/s41586-025-08953-9
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Hard agree. Great article on a timely issue by
@neuralreckoning.bsky.social
for
@thetransmitter.bsky.social
add a skeleton here at some point
4 months ago
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Mac Shine
The Transmitter
4 months ago
Large-scale projects run the risk of stifling scientific independence. Instead, let’s explore alternative mechanisms of collaboration, writes
@neuralreckoning.bsky.social
.
#neuroskyence
www.thetransmitter.org/funding/neur...
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Neuroscience needs to empower early-career researchers, not fund moon shots
Large-scale projects run the risk of stifling scientific independence. Instead, let’s explore alternative mechanisms of collaboration.
https://www.thetransmitter.org/funding/neuroscience-needs-to-empower-early-career-researchers-not-fund-moon-shots/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20250526-neuroscience-needs-empower-ECR
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Claire O'Callaghan
4 months ago
Together with
@macshine.bsky.social
&
@elimuller.bsky.social
we have a cool interdisciplinary project on compositional cognition, and we’re looking for a PhD student. More details here
www.findaphd.com/phds/project...
DM or email any questions Please RT or pass on to interested students. Thanks!
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Met4Cast
4 months ago
This is phenomenal. Sea surface temperatures are >5C above average to the west of the UK and around Iceland. It's the strongest area of anomalous warmth on the planet at the moment. It's the warmest in recorded history for northwest Europe.
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Maximiliano José Nigro
4 months ago
I fell in love with neurophysiology because of the beautiful biophysical properties of stellate cells
pubmed.ncbi.nlm.nih.gov/8395571/
Finally I go back to these cells and put biocytin in them and what a wonderful surprise Stained and imaged by Kristian Moan
@gquattrocolo.bsky.social
#neuroskyence
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Mac Shine
The Transmitter
4 months ago
Applications are now open for our fall internship program! This is an excellent opportunity for a beginning science journalist to report and write about the fast-moving field of neuroscience. Apply now:
simonsfoundation.wd1.myworkdayjobs.com/en-US/simons...
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Science Reporting Intern, The Transmitter
The Transmitter offers up-to-date news and analysis of neuroscience and is dedicated to helping scientists at all career stages stay current and build connections. Our award-winning news team is seeki...
https://simonsfoundation.wd1.myworkdayjobs.com/en-US/simonsfoundationcareers/job/Science-Reporting-Intern--The-Transmitter_R0001874
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Mac Shine
Meike van der Heijden
4 months ago
Purkinje cells form inhibitory connections on cerebellar nuclei cells. So, when Purkinje cells fire abnormally, as in disease states, we should see the inverse in nuclei cells, right? Well - it may not be so straightforward:
tinyurl.com/PCtoNC
@fralinbiomed.bsky.social
@vtneuroscience.bsky.social
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Purkinje Cell spike patterns do not correlate with nuclei cell spike patterns in mouse models for cerebellar disease
Cerebellar dysfunction causes various movement disorders, including ataxia, dystonia, and tremor. Previous work demonstrated that spike patterns in cerebellar nuclei neurons were distinct between diff...
https://tinyurl.com/PCtoNCinDisease
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Mac Shine
Annie G. Bryant
4 months ago
Big shout-out to
@jlizier.bsky.social
, whose patience, dedication, and guidance in supervising me through this project have been invaluable 🙏 Thank you also to our other fab co-authors for their insightful input as always: Oliver Cliff,
@macshine.bsky.social
, and
@bendfulcher.bsky.social
!
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Gary Marcus
4 months ago
A computer scientist’s perspective on vibe coding:
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Mattia Rigotti
4 months ago
The data processing inequality does state that the brain cannot generate new information ABOUT the external world. But technically, being a source of entropy, the brain DOES generate information. And that might have implications, e.g. vis-à-vis resting states, default mode networks, delusions, etc
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The Transmitter
4 months ago
Want to stay up to date on the latest developments in human brain mapping? As part of a new partnership, we are excited to announce the launch of a joint quarterly newsletter with
@ohbmofficial.bsky.social
. Sign up for the latest on neuroimaging research:
www.thetransmitter.org/newsletters-...
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Newsletters and alerts
The latest news and perspectives on the neuroscience topics that interest you most, direct to your inbox
https://www.thetransmitter.org/newsletters-alerts/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20250516-rp-OHBM-newsletter
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