savethevetschool.co.uk Colleagues, please lend us your support. The University wants to close down the vet school despite being ranked educationally above school average and smashing the REF because they want our land and vet education is too expensive.

Our work on the mechanism of bedaquiline is now published. Nat Comms has open peer review so anyone can see the critical but constructive and supportive peer review we received. Thanks again to @morwan.me on BlueSky, and Suzy, Rowan, Greg, Chen-Li, and Roger who aren't. Original thread below

Three senior CDC leaders who resigned told The Post they were asked to participate in an unscientific vaccine recommendation process that they believe could harm the health of Americans.

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

🦠 NEW VIDEO 🦠 The molecular biology of how Mycobacterium Tuberculosis evades the immune system so well. Starting with this simulation of a full outer envelope of m.TB--let's explore how the deadliest & most persistent human pathogen completely hacks our immune response. #molecularbiology

Bedaquiline resistance driven by the MmpS5L5 efflux pump is threatening the drug regimens used to treat MDR-TB. In our new preprint, we used structural and genetic approaches to better understand how MmpS5L5 effluxes bedaquiline and how future resistance may evolve. 🧵🔽 #TBsky #MicroSky #TB

Challenging times for biomedical research in the U.S. One of our grants was terminated and two others frozen. Thinking of colleagues from Bethesda to Boston to South Africa who are facing the same uncertainty. Now more than ever, we must speak up for the value of this work.

Antifungal drug discovery gets an interesting and unexpected shot of good news:

Statement from WHO TB program on the impact of USAID cuts. TLDR: it's devastating. hq_globaltuberculosisprogramme.cmail19.com/t/d-e-stuitu...

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...

Lysenkoism was a Soviet-era pseudoscientific movement led by Trofim Lysenko, and endorsed by Stalin. It rejected established genetics science in favor of politically driven, unproven agricultural theories and ideological loyalty, leading to widespread crop failures and famine.

Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself!

Our first TB preprint with @jnb-lab.bsky.social is out! Using spectroscopic techniques from our lab, we resolve the exact mode of action of everyone's favourite TB drug, bedaquiline. I'd like to add a few comments about the microbiology part of the picture! #TBsky #MicroSky (1/7)

Finally we are able to share our story on the molecular mechanism of the transformative anti-tuberculosis drug bedaquiline within living cells www.biorxiv.org/content/10.1... A (hopefully) broadly-accessible tutorial below ⬇️ (it ended up being really long!)

Chai-1, the open source AF3 clone, is now available with an Apache 2 license github.com/chaidiscover...

We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!

Charles Darwin and Robert Koch walked into a bar... find out the outcome of this interaction here: elifesciences.org/reviewed-pre...

Been thinking about creating a collection of good protein structure figures, as inspiration for my own work. #1 www.nature.com/articles/s41...