How does the strength of genetic drift evolve over long times? New preprint out 👇 www.biorxiv.org/content/10.6...

Excited that SpaceBar is now out in Nature Methods!🥳 We combined clone tracing with spatial transcriptomics to untangle what drives gene expression in tumors: a cell's identity or its neighborhood? Most genes were driven by location, but some showed strong clonal patterns. rdcu.be/eVhpc

Working on this paper fundamentally changed how I thought about bacterial evolution, and I couldn't ask for a better to Hannukah present than to see it out, at last!

If you are interested in this work and are looking for a postdoc position, please get in touch -- we are actively looking for someone to join our group at UCLA!

Grateful to share our paper on gene-specific selective sweeps in human gut microbiomes, now out in Nature! It has been a joy to work with @rwolff.bsky.social, whose insights and hard work made this possible. www.nature.com/articles/s41...

So excited to share this work led by @alexrob.bsky.social with Ben Kerr! We investigated a poliovirus capsid inhibitor that exploits a breakdown in the genotype-phenotype map to prevent drug resistance evolution. Or does it? See Alex's thread, but a few extras: #socialviruses #evosky #virosky 🧪

Genuinely one of the most important and interesting papers I have been a part of! Relevant to fundamental questions regarding the predictability of adaptation, as well as the applications of genomic data. Congrats to @j-smiley-rhodes.bsky.social and all co-authors for such a masterpiece!

Super excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n) www.biorxiv.org/content/10.1...

One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...

One week to apply for our fully funded PhD position in Norway! This is a really exciting project in collab. with University of Helsinki and Benchmark Genetics. Samples are ready - you do (read: learn) everything - functional genomics, bioinformatics, genotype-phenotype associations 🤩 Please RT!

Human-mediated land-use and climate change occur simultaneously, but how do they interact to shape adaptive dynamics? Super excited to share the first paper from the Kreiner lab, led by postdoc extraordinaire @rpineau.bsky.social

New preprint led by undergrad Owen Moosman! We uncover extensive haplotype diversity in antifreeze protein gene copy number in polar Zoarcoidei fishes, and report new tools to evaluate assembly uncertainty and switch error in phased genomes www.biorxiv.org/content/10.1...

Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...

How do populations maintain an evolutionary memory? I am happy to share that our work with Dmitri Petrov @petrovadmitri.bsky.social, Paul Schmidt, and colleagues on dominance reversal and stabilization of insecticide resistance in changing environments over time is now published at Nature EE.

Check out our paper in Evolution Letters! We used D. melanogaster pigmentation as a focal trait to explore parallelism in phenotypic and genomic responses to environmental change - read more at the link below 👇

I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!

Come join us at UCLA!!! We have a growing population genetics community here and Nandita and her lab are outstanding!

The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more. recruit.ap.uci.edu/JPF09601

We are recruiting students who are thinking of applying to Biology PhD programs this fall to apply for the Stanford Biology Preview Program. Please spread the word!

1/n 🧵 Excited to share our new paper! We developed a framework to reveal hidden simplicity in how organisms adapt to different environments, particularly focusing on antibiotic resistance evolution. #EvolutionaryBiology #MachineLearning

1/9 Excited to share the preprint for the second half of my PhD with @mollyschumer.bsky.social: Connecting human environmental impacts to hybridization in swordtail fish through genomics, GIS, water chemistry, and histology. Thread below! #SciSky www.biorxiv.org/content/10.1...

Excited to share the first manuscript from my PhD in which we leveraged ultra-long Nanopore sequencing, D. melanogaster inbred lines, and a ton of manual validation to investigate the effects of long-read length on population-level structural variant (SV) calling accuracy! doi.org/10.1101/2025...

Our commentary on the elegant in vitro microbiome coalescence experiments from @goldmandoran.bsky.social @ksxue.bsky.social et al is out. It was a pleasure to write about one of my favorite microbiome papers of the last few years. www.pnas.org/doi/10.1073/...

1/ Hey y'all, I'm excited to share my latest paper, which is out now in PNAS! We introduce FAVA, a statistical framework to measure compositional variability across microbiome samples. If you want to measure variability across a stacked bar plot, FAVA is for you! Paper: doi.org/10.1073/pnas...

Thank you for the coverage! Excited that this work, in collaboration with @markcbitter.bsky.social and many others, is now out!

A new study led by #EnvironmentalHealth postdoc Lisa Couper finds #mosquitoes may genetically adapt to #ClimateChange more than expected. Her team's findings show increasing risk of #WestNileVirus, #Malaria & other diseases due to the insects' heat tolerance. #GlobalWarming ow.ly/Uzro50V3BRl

Late-stage PhD students: We want to bring you to NYU Biology to meet peers and make connections with potential postdoctoral mentors. Apply to be part of our Emerging Scholars Symposium!

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.

Join us at the Gordon Research Seminar (GRS) on Ecological and Evolutionary Genomics in Tuscany, co-chaired by @jcbnunez.bsky.social and me. If you’d like to present your research and be considered for a talk, make sure to submit your application before April 6th!

Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org

How is functional variation at large-effect loci maintained in natural populations? Thrilled to share our work showing how beneficial dominance reversal helps fruit flies maintain a resistance polymorphism as selection varies in their environment! A thread 🧵 1/n www.biorxiv.org/content/10.1...

Thrilled to see this work, led by @lisacouper.bsky.social now out! We quantified variation in thermal tolerance in the mosquito, Aedes sierrensis, to quantify how adaptation may alter disease vector distributions under warming. 🧵 www.pnas.org/doi/10.1073/...

Thrilled to see this work, led by @lisacouper.bsky.social now out! We quantified variation in thermal tolerance in the mosquito, Aedes sierrensis, to quantify how adaptation may alter disease vector distributions under warming. 🧵 www.pnas.org/doi/10.1073/...

Happy that this paper - www.biorxiv.org/content/10.1... - was accepted at Mol Ecol Res and excited about the promise of this technology to measure pop sizes for such elusive species as snow leopards + learn about at least 1st-degree relationships + beyond? Congrats to Katie Solari and other authors!

This collaboration was such a pleasure. Our new paper on cascades of HT after introduction of two TEs to human commensals www.nature.com/articles/s41...

I enjoyed participating in the symposium on genetic time series to understand microevo & eco dynamics @ ASN25 organized x Brian Reid & featuring @meaghansaurus.bsky.social @markcbitter.bsky.social @renedelight.bsky.social @isaacovercast.bsky.social ! Can you believe this incredible impromptu art?!

Registration is now open for the Gordon Research Seminar (GRS) on Ecological and Evolutionary Genomics in Tuscany, co-chaired by me and @jcbnunez.bsky.social! www.grc.org/ecological-a...

This meeting is a unique opportunity for early-career researchers to present their work and network. The GRS precedes the GRC, which features an incredible line-up organized by @chicascientifica.bsky.social and @samyeaman.bsky.social For more information about the GRC: www.grc.org/ecological-a...

A week left to register for the BEST evolutionary ecology meeting out there, @asn-amnat.bsky.social American Society of Naturalists in Asilomar CA Jan 3-7. Great science, great location, friendly people, small format to encourage conversation. asnasilomar2025.org/default.html Please please join us!

Do mutations that drive evolution improve many traits or few? Does this change over the course of evolution? Excited to share our work in PLOS Biology exploring these questions in the first 2 adaptive steps w/ Yuping Li, @gsherloc.bsky.social, @petrovadmitri.bsky.social 🧵 doi.org/10.1371/jour...

Excited to share a new preprint with @jnovembre.bsky.social ! We use a combination of population genetic theory, simulation, and data analysis to ask: how does study design in genetic studies (including biobanks) impact the discovery of rare, deleterious variants?

The typeset version of our article, "Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation", is now online. This thread will provide an overview of how gene duplications have shaped modern variation in the amylase locus. www.science.org/doi/10.1126/...

We usually think of genetic drift as the predominant stochastic force in evolving populations. But working with some model microbial populations, we found a distinct source of demographic stochasticity that scales (and behaves) differently than drift Learn more in our new paper 👉 rdcu.be/d07Np

Looking forward to the 2025 Ecological and Evolutionary Genomics Gordon Conference in Italy this summer! This meeting was fantastic in 2023 and promises to be outstanding again! Get more info and register here: www.grc.org/ecological-a... @samyeaman.bsky.social @chicascientifica.bsky.social

I used paper by @alisonfeder.bsky.social @pleunipennings.bsky.social & @petrovadmitri.bsky.social in class yesterday. It makes v. useful point about softsweeps in viral time series. But its also v useful for motivating calculations on the probability of loss journals.plos.org/plosgenetics...

Extremely happy to share our latest work on the functional genetic basis of maturity age variation in Atlantic salmon! 🖥️🧬🦑🧪🐟 www.pnas.org/doi/10.1073/...

Hi friends new and old! I study how microbes interact and evolve in complex communities like the human gut microbiome.🦠🧬💩 I'm thrilled to share that I'm starting a lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! kxuelab.com More about my work below...🧵1/n

Very proud to be a part of this incredible effort! "Footprints of worldwide adaptation in structured populations of D. melanogaster through the expanded DEST 2.0 genomic resource" www.biorxiv.org/content/10.1...

Delighted to share that our paper on discovering selective sweeps with haplotype statistics in aDNA is now out in Nat. Comm! www.nature.com/articles/s41... Wonderful collaboration with Vagheesh Narasimhan, Devansh Pandey, and @mharris.bsky.social

Excited to share a new manuscript in which we used simple lab-based experiments to quantify a genome-wide signal of trade-offs in response to temporally fluctuating selection! 1/n