Thrilled to have my first PhD paper with @mmdesai.bsky.social out! @science.org Link: www.science.org/doi/10.1126/... Thread below: #mevosky #evosky #evobio #popgen #evolsky #ecoevo #molevol

We are destroying species' habitats, leading to a mass extinction event. This habitat destruction also reduces the genetic diversity _within_ species. Our latest work develops quantitative models to predict how much genetic diversity has been and _will be_ lost. 🧬🧪🧵 www.pnas.org/doi/10.1073/...

Really excited that this major work from my PhD is finally published in @plosbiology.org ! In it, we were trying to tackle a fundamental question in evolution - how do genetic mutations map onto evolutionary fitness? (1/n) journals.plos.org/plosbiology/...

Proud that this work is now published! We hope it helps orient future #Nanopore long-read sequencing studies hunting for structural variants Also really happy to share eight new high-coverage (>100x) long-read read pools and assemblies with the #Drosophila community! doi.org/10.1093/g3jo...

An NIH-funded postdoctoral position is available in my lab. The project focuses on the structural and mechanistic basis of antibody recognition of M and M-like proteins of Strep A (Streptococcus pyogenes).

Excited to share this new preprint describing how Strep A proteins bind human factor H. Strep A is a major human pathogen that causes not only Strep throat but also severe invasive diseases, like 'flesh-eating disease'. www.biorxiv.org/content/10.1...

Thrilled to finally share the magnum opus of my PhD that focuses on the genetic basis of evolutionary change! Specifically, we know we can map the genetic basis of a trait, but can we tell which genes will underlie the trait shift when it evolves? doi.org/10.1101/2025...

Excited to share some new work led by grad student Sophie Walton (w/ @petrovadmitri.bsky.social). We used in vitro gut communities to study how natural selection acts on strains of the same species as they compete within larger communities. Check out Sophie's thread below for details!

Super excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n) www.biorxiv.org/content/10.1...

One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...

I'm very excited to share something I've been working on off-and-on for a long time now: a new blog about genotype-phenotype landscapes! The first post is a Gödel-Escher-Bach-style dialogue to introduce the topic. If you like it please share/repost! open.substack.com/pub/topossib...

Having a great time at #smbe2025! So many great talks and conversations. Thank you again to @iamphioxus.bsky.social for the opportunity to present our work! Much of it is from the paper by @grantkinsler.bsky.social and @yuping-li.bsky.social journals.plos.org/plosbiology/... 1/n

Grateful to be talking at #Evol2025! Will be presenting on how long Nanopore reads need to be in order to accurately call structural variants in Drosophila at the population level. Talk is at 3pm on Saturday in the Genomics III section. If you can’t make it get in touch!

Looking forward to #evolution2025! I will be talking about how time-varying demography and selection shape the site frequency spectrum — Saturday at 4:15 pm, Population Genetics Theory IV. Come say hi if you are around!

Super excited for #Evol2025! I will be sharing some cool work on selection in the gut microbial communities at 9:30 am on Monday in the Evolutionary Ecology I session (Parthenon 2)!! Looking forward to chatting with folks as well!

I think this emphasizes the need for more concrete models of pleiotropy to help us know when these verbal models should even apply in principle (let alone in expts like @oliviamghosh.bsky.social's). In that vein, was very excited about the new work that @djhelam1.bsky.social‬ talked about at NITMB

Excited to share the first manuscript from my PhD in which we leveraged ultra-long Nanopore sequencing, D. melanogaster inbred lines, and a ton of manual validation to investigate the effects of long-read length on population-level structural variant (SV) calling accuracy! doi.org/10.1101/2025...

Excited to share SpaceBar - our new method for labeling and detecting clones with imaging-based spatial transcriptomics platforms! w/ Yael Heyman and @arjunraj.bsky.social www.biorxiv.org/content/10.1... 🧵

How is functional variation at large-effect loci maintained in natural populations? Thrilled to share our work showing how beneficial dominance reversal helps fruit flies maintain a resistance polymorphism as selection varies in their environment! A thread 🧵 1/n www.biorxiv.org/content/10.1...