*Crosses off ‘Fellowship of the Royal Society’ as a life goal*.

Statement on the Royal Society website is here. The fact that this is the definitive statement makes me even more convinced that they aren't doing anything to censure Musk. royalsociety.org/news/2025/10...

DNA variants modulate each other’s effects, but finding interactions in population cohorts is hard due to tiny effect sizes + massive testing burden. Using TarGene on 9 nuclear hormone receptor mechanisms we uncovered 535 2-point & 185 3-point interactions, revealing sex-biased genetic risk. (2/n)

We integrate population genetics, functional genomics & targeted ML to uncover 100s of TF-linked epistatic interactions across 768 traits in UK Biobank. Epistasis, informed by mechanism, empowered by robust stat/ML, is detectable & widespread. doi.org/10.1101/2025... (1/n)

As my daughter got sicker and sicker, our quest for answers dragged on. How did we all miss the bacteria taking over her body?

While we welcome the Scottish Government announcement of £4.5 million recurrent #LongCovid and #MECFS funding, serious concerns remain. Patients are told money is being allocated, but there is no clarity on how it will be used. Read the full statement on our website: www.longcovid.scot/blog/res...

Energy transition and UK politics. This is an area where I am definitely an amateur, armchair expert, but interested and can... read a chart etc. Politically I am just a citizen really. Still I think we're going to be entering an interesting phase in the energy transition and UK politics.

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

Animals Sleep Because Electrons Leak The need for sleep likely evolved to get rid of toxic molecules from the mitochondria, a landmark study shows using sleep-deprived flies. Written byAndrea Lius, PhD www.the-scientist.com/animals-slee... #neuroscience #research #sleep #evolution #education 🧪

“The big perspective change from ancient DNA study is that people living today are almost never the descendants of the people in the same place thousands of years before” news.harvard.edu/gazette/stor...

Mini-scoop: After resisting pressure to strip Elon Musk of his fellowship for months, the Royal Society is meeting on 1 October to discuss his removal – following his decision to address Tommy Robinson's far-right rally on Saturday. www.thenewworld.co.uk/james-ball-r...

I've been following the field of biosensors for nearly 2 decades. This may well turn out to be the most important advance yet erictopol.substack.com/p/biosensors...

IGC is looking for a Core Facility Bioinformatician to provide bioinformatics expertise and support to researchers across the Institute, working at the intersection of computational and experimental science. Find out more and apply by 13 October: edin.ac/3R5dEBU @cmvm-edinburghuni.bsky.social

Had a txt from a contributor asking how I dealt with seeing so much suffer & it's true that sometimes I was v shaken - drove off with camerbag in the gutter once - but mainly I was angry. What other disease affects 400,000 but is virtually invisible? #pwme #mecfs #millionsmissing #invisibleillness

Cells swapping their #mitochondria - this sounded like science fiction 🧪 when the first studies started coming out! But now this has been observed in #cancer, #yeast, #molluscs, and under normal physiology - as a way to regulate energy demands, metabolism, cell fate & much more - true #powerhouses!

Seeking a Project Manager for the PRIME project: "Building Infrastructure for Patients, Researchers and Industry for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Closing date for applications is 15 September 2025. #pwME #MEcfs elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

The ME Association are pleased to announce that we have awarded Decode ME the Howes-Goudsmit Award 2025 for their extensive work and commitment to their genome-wide association study. Find out more: https://meassociation.org.uk/ir3e #MECFS #pwME #SevereME #MyalgicE #DecodeME #HowesGoudsmitAward

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:

BBC: 'Is the DNA of people with ME different?' 'We meet the scientist behind the research – Professor Chris Ponting – and Laura Boyles who has been living with the condition for 15 years.' www.bbc.com/audio/play/p...

Our genetics results webinar recording is now available! Thank you to the 2500+ people who joined us live last week. For those who want to watch back, or who couldn’t attend you can find it on our new website, here: shorturl.at/Uh8xb

If you believe that keeping your head down and being quiet will spare you from this fate, you are mistaken. This will be all of us.

Can science crack the mystery of ME? – podcast

ME Research UK and the Daphne Jackson Trust are delighted to announce the award of a Fellowship to Dr Alkisti Manousaki (Uni of Leicester) for a project investigating the genetic and cellular clues that may explain why ME/CFS affects more women than men. bit.ly/manousaki001 #mecfs #cfs

Isn't genetics cool??? Within only 145 nucleotides(!) of a non-coding RNA (RNU4-2) - different variants in distinct regions / structures cause three distinct disorders!!! (all discovered within the last 18 months) 🤯🤓🧬❤️

DecodeME is exceptional in how you engaged with lived experience. Yes, the GWAS outcome is huge, but I genuinely am almost more excited about how you centered on lived experience. I would love you to run workshops for other ME researchers so they can learn your best practices.

I think in 10 to 20 years time there will be a wide array of somatic CRISPR therapeutic techniques on a subset (but probably not all) tissues in the human body; this will allow one to at least improve, if not cure, many rare genetic diseases (some will not - development or needs near 100% edits)

"It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. (...). There are three fundamental pleasures that have sustained me through 50 years of this madness." journals.biologists.com/jcs/article/...

Join us TOMORROW for our genetic results webinar! Register here: shorturl.at/fnB67 There are limited spots to join on Zoom (registering does not guarantee a spot). Don’t worry though, we will be recording it and we will also be sharing it live on Facebook at the time.

New course announced! We're thrilled to be hosting the @embo.org Practical Course 'Causality in biomedicine: going beyond associations' from 4 – 9 October 2026. Register your interest and be the first to hear when the course opens for applications: www.ebi.ac.uk/training/eve...

New course “EMBO Causality in Biomedicine”: We have organised the first EMBO course in *causal* stats/ML methods for quantitative biomedicine. @sjoerdvbeentjes.bsky.social @nimahejazi.org @pablormier.bsky.social @DariaSokolova @CarolineUhler Very much looking forward to teaching and discussing!

Absolutely beautiful and personal story from @binitakane.bsky.social of why south Asian heritage month matters to the NHS- how her doctor parents migrated to the UK, each with £3.50 in their pockets in 1969 to join our NHS

Here's a video by Dr. Jarred Younger explaining the functions of the 8 genes found to be associated with #MEcfs. youtu.be/clwN51nkZAk?...

1) Saw some skepticism about DecodeME, asking if it is overhyped. As an account that focuses on critically analyzing research (our name was 'ME/CFS Skeptic' for a reason!), we think it’s the real deal. Here are a couple of reasons why it stands out. 🧵

Letter from @strangerandstranger.net in Times today #MEcfs #DecodeME #LongCovid

Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome now on medRXiv www.medrxiv.org/content/10.1...

Looking for a new opportunity in computational genomics? Join our group @uoe-igc.bsky.social @edinburgh-uni.bsky.social Deadline September 1! elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

'Each genetic signal is like an ‘X’ on a treasure map indicating roughly where the researchers should dig for treasure.' Check out Simon McGrath’s blog to learn about the science behind the initial results: shorturl.at/hadjF

For #ME/CFS, genomics assessed in >15,000 indviduals with 8 genomic loci identified. "Validation of ME/CFS as a biomedical condition and an important corrective to psychologizing ‘all in the mind’ perspectives on the disease” www.science.org/content/arti... www.research.ed.ac.uk/en/publicati...

Scientists find link between genes and ME/chronic fatigue syndrome

DecodeME results are out! So inspired by my incredible colleagues at UoE who have carried out this research to the highest standard. I hope these results will bring about a paradigm shift in ME/CFS research and attract more interest and investment to the field. shorturl.at/VwN3s #DecodeME

Science magazine’s coverage of the DecodeME initial results : www.science.org/content/arti...

Our initial DNA results! DecodeME have discovered that people with an ME/CFS diagnosis have significant genetic differences compared to the general population. - Summary of our results: shorturl.at/pgsjk Check out our full preprint paper: shorturl.at/VwN3s

FAQs on the #DecodeME #MECFS results www.decodeme.org.uk/faqs/

✅ Published in @natureportfolio.nature.com today, the paper describing the initial whole-genome sequencing analysis of 500,000 UK Biobank participants. Read here: www.nature.com/articles/s41...

How does Epstein- Barr virus induce multiple sclerosis? The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model) www.nature.com/articles/s41...

1/13 In a new preprint, we (with @xliaoyi.bsky.social‬ in the ‪@arbelharpak.bsky.social‬ lab) find that expression from the “inactivated” X (Xi) is consequential for both female-male differences in gene expression and variation among females in disease and physiology: www.biorxiv.org/content/10.1...

Today, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community. reeserichardson.blog/2025/08/04/a...

DecodeME results will be released on Wednesday! @decodemestudy.bsky.social email We plan to send you an email with our findings on Wednesday 6th August around 7pm [UK time] . We will also be announcing the results on our website at this time.

Exciting! DecodeME: "the initial DNA results from the DecodeME study will be available in the next few days" www.decodeme.org.uk #MEcfs #PwME #CFS

My new PLOS Bio piece about when one's work is misrepresented: "[T]here is a normative expectation within scholarly research that all parties are well-intentioned and truth-seeking...when invitations to engage genuinely are not accepted..scholarly discourse is ill-equipped to resolve the conflict."