New📢 Between molecular and human traits is a yawning gap: What do molecules do to single cells? We tested *all* human or mouse miRNA mimics for their cell morphological effects on 5 cell lines. To do so, we applied Cell Painting at the *single cell* level (100,000+ images). doi.org/10.1101/2025...

Interested in ME/CFS research? Want to do a PhD with @aryback.bsky.social, @avakhamseh.bsky.social, @sjoerdvbeentjes.bsky.social & @cgatist.bsky.social? Then apply for a *funded* Future Medicine PhD Fellowship. See: www.findaphd.com/phds/project... Please contact us to discuss before applying.

We integrate population genetics, functional genomics & targeted ML to uncover 100s of TF-linked epistatic interactions across 768 traits in UK Biobank. Epistasis, informed by mechanism, empowered by robust stat/ML, is detectable & widespread. doi.org/10.1101/2025... (1/n)

New course “EMBO Causality in Biomedicine”: We have organised the first EMBO course in *causal* stats/ML methods for quantitative biomedicine. @sjoerdvbeentjes.bsky.social @nimahejazi.org @pablormier.bsky.social @DariaSokolova @CarolineUhler Very much looking forward to teaching and discussing!

📢 Now published: www.embopress.org/doi/full/10..... Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences. bsky.app/profile/cgat...

📢Now published! Know that clustering cells in reduced dimensions is problematic? Want to identify cell subtypes or states *without* clustering? Then check out Stator which finely resolves states & subtypes even among apparently homogeneous cells Thread www.embopress.org/doi/full/10....

I am STOKED that myself and @avakhamseh.bsky.social are looking for a joint EastBIO PhD candidate across @uniofaberdeen.bsky.social and @uoe-sps.bsky.social to develop cutting-edge statistical models at the interface of single cell genomics and quantitative genetics: shorturl.at/vQo0P pls reskeet!