Matthias Löhr ʚїɞ
@maloehr.bsky.social
📤 482
📥 144
📝 171
Professor of Gastroenterology at
#Karolinska
Institutet.
#Pancreas
lover.
reposted by
Matthias Löhr ʚїɞ
Karolinska Institutet
6 days ago
Addressing iron status may be relevant for
#dementia
prevention and healthy
#ageing
, suggests a KI study published in BMC Medicine
@bmc.springernature.com
. Both absolute and functional iron deficiency were linked to higher dementia risk in older adults. 🧪
#aging
doi.org/10.1186/s129...
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Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS - BMC Medicine
Background Iron deficiency (ID) is proposed to be involved in cognitive aging and dementia; however, empirical data is lacking to support this hypothesis. We examined the association between absolute and functional ID and incident dementia diagnosis. Methods Data from 70,935 individuals aged ≥ 50 years from the Swedish AMORIS cohort, who had blood measurements indicative of iron status between 1985–1996, were used. Participants were followed for incident dementia diagnosis recorded in National Patient Register (inpatient and specialist outpatient) and Prescribed Drug Register (dispensed anti-dementia drugs) for up to 15 years. Two exposure groups were defined: absolute iron deficiency (serum ferritin < 30 ug/L) and functional iron deficiency (transferrin saturation < 20% and serum ferritin ≥ 30 ug/L). The reference group included individuals with measurements in the normal range of hemoglobin, serum iron, and total iron binding capacity. Results A total of 4,994 individuals received a dementia diagnosis over a mean of 12.6 years. Compared with the reference group, absolute and functional ID was associated with increased dementia diagnosis (adjusted hazard ratio (HR) = 1.24, 95% confidence interval (CI): 1.18–1.42; HR = 1.21, 95% CI: 1.05–1.39, respectively), after adjusting for age, sex, education, and comorbidities. The associations were essentially consistent across subgroups, and when further adjusting for kidney function, body mass index, and smoking in subsamples. Conclusions Even though absolute and functional iron deficiency has different underlying mechanisms, we found that both conditions are associated with an increased risk of dementia. Considering that iron deficiency is a pervasive but often neglected health issue in older adults, resolving iron deficiency may be relevant for dementia prevention.
https://doi.org/10.1186/s12916-026-04839-3
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💡 Pancreatic exocrine insufficiency (PEI) is common, yet frequently unrecognised. PEI is a common driver of malnutrition. PEI is a maldigestion syndrome that demands a structured, context-driven approach.
@myueg.bsky.social
🔗 Access the full article on Gutflix:
bit.ly/4mDbeJF
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Mistakes in Pancreatic exocrine insufficiency and how to avoid them
Pancreatic exocrine insufficiency (PEI) is a common yet frequently under-recognised cause of maldigestion, malabsorption, and malnutrition. Although traditio...
https://bit.ly/4mDbeJF
6 days ago
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reposted by
Matthias Löhr ʚїɞ
PANCAID
10 days ago
Detecting cancer early can dramatically improve outcomes. This week's glossary carousel explains: • Diagnosis • Screening • Early detection These concepts are central to ongoing research aimed at improving survival rates for pancreatic cancer.
#EarlyDetection
#CancerAwareness
#PancreaticCancer
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Following the
#guidelines
for
#pancreaticexocrineinsufficiency
supported by
@myueg.bsky.social
@uegj.bsky.social
, we put together a review covering the important aspects, now published in a
@elsevierconnect.bsky.social
journal,
@eclinicalmed.bsky.social
authors.elsevier.com/sd/article/S...
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ScienceDirect.com | Science, health and medical journals, full text articles and books.
https://authors.elsevier.com/sd/article/S2589537026001276
11 days ago
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reposted by
Matthias Löhr ʚїɞ
Lesley Goodburn
11 days ago
medicalxpress.com/news/2026-04...
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Reprogramming regulatory T cells could help immunotherapy work in pancreatic cancer
Researchers at Oregon Health & Science University have uncovered a key reason why immunotherapy has largely failed in pancreatic cancer—and identified a promising strategy to overcome that resistance....
https://medicalxpress.com/news/2026-04-reprogramming-regulatory-cells-immunotherapy-pancreatic.html
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
13 days ago
🥗 Sucrase-isomaltase variants do not influence #FODMAP diet outcomes in #IBS 🔸 54% carried ≥1 hypomorphic SI variant 🔸 Initial & long-term diet response similar across genotypes 🔸 Dietary intake unaffected by carrier status Read more in UEG Journal: 👉
https://bit.ly/4vhwxoj
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This is the way to go! As we are doing w/
@pancaid.bsky.social
add a skeleton here at some point
12 days ago
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KRAS G12D - that’s the one for
#pancreaticcancer
!
add a skeleton here at some point
12 days ago
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reposted by
Matthias Löhr ʚїɞ
Lesley Goodburn
12 days ago
www.mdanderson.org/newsroom/res...
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Researchers find new target to sensitize pancreatic tumors to immunotherapy
Researchers find new target to sensitize pancreatic tumors to immunotherapy
https://www.mdanderson.org/newsroom/research-newsroom/researchers-find-new-target-to-sensitize-pancreatic-tumors-to-immunotherapy.h00-159854556.html
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reposted by
Matthias Löhr ʚїɞ
Pancreatic Cancer Europe
14 days ago
PCE is pleased to introduce Patrycja Rzadkowska, Patient & PCE Vice Chair, Poland for the upcoming masterclass: Patrycja will share insights on supporting patients in the disease process, emphasising patient-centred care. 📅 Monday, 27 April 2026 🕒 13:45 – 17:00 CEST 📍 Grand Hotel Excelsior Malta
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reposted by
Matthias Löhr ʚїɞ
Karolinska Institutet
14 days ago
Gut bacteria appears linked to how much latent
#HIV
remains in the blood during antiretroviral therapy, a study in Gut Pathogens shows. Findings suggest the gut
#microbiome
may influence how much virus persists in the body 🧪
news.ki.se/gut-bacteria...
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reposted by
Matthias Löhr ʚїɞ
Pancreatic Cancer Europe
16 days ago
On
#WorldHealthDay
, we are reminded that health is a fundamental right, yet for many people affected by pancreatic cancer, timely diagnosis, access to treatment, and quality care remain out of reach. Today, we stand united to change that. 🌍💜
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reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
16 days ago
ICYMI: New online! Pathophysiology of colitis-associated colorectal cancer
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Pathophysiology of colitis-associated colorectal cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 01 April 2026; doi:10.1038/s41575-026-01197-6In this Review, Neufert and Neurath discuss the pathophysiological mechanisms of colitis-associated colorectal cancer, focusing on the tumour epithelium, stromal cells, mucosal barrier and mechanisms of tumour development. They also discuss potential implications for personalized therapy.
http://dlvr.it/TRwGmG
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reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
15 days ago
New online! The microbiome regulates host metabolic health and diseases through microbial enzymes
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The microbiome regulates host metabolic health and diseases through microbial enzymes
Nature Reviews Gastroenterology & Hepatology, Published online: 07 April 2026; doi:10.1038/s41575-026-01195-8In this Review, Jiang and colleagues describe how gut microbial enzymes regulate host metabolic health and diseases. They also discuss the methodology for studying gut microbial enzymes and their potential clinical applications.
http://dlvr.it/TRwk31
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Important Meeting to raise awareness for
#pancreaticcan
er
add a skeleton here at some point
15 days ago
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reposted by
Matthias Löhr ʚїɞ
JAMA
15 days ago
📊 JAMA Clinical Guidelines Synopsis: #CrohnDisease guidelines recommend fecal calprotectin for screening and monitoring, routine colonoscopy for colorectal cancer, and oral budesonide for induction in mild to moderate ileocecal disease.
ja.ma/47QA5ng
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reposted by
Matthias Löhr ʚїɞ
wemeze
18 days ago
#wemezeclassics
28
1783
573
reposted by
Matthias Löhr ʚїɞ
Let's Win Pancreatic Cancer
18 days ago
Sending love and hope to the Let's Win community this Easter. 💜
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reposted by
Matthias Löhr ʚїɞ
WHO
about 2 months ago
Women play a vital role in science. A powerful reminder from mRNA researcher and Nobel Prize winner Prof. Katalin Karikó on why science needs more women!
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#diabetes
can cause
#pancreaticexocrineinsufficiency
after year of insulin dependency! See the recent
@myueg.bsky.social
guidelines published in
@uegj.bsky.social
add a skeleton here at some point
2 months ago
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1
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reposted by
Matthias Löhr ʚїɞ
Lesley Goodburn
2 months ago
www.cancernetwork.com/view/how-the...
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How the PRECEDE Consortium is Redefining Pancreatic Cancer Detection | CancerNetwork
Diane Simeone, MD, detailed how the PRECEDE Consortium utilizes standardized data sharing and high-risk screening to identify stage I pancreatic cancer.
https://www.cancernetwork.com/view/how-the-precede-consortium-is-redefining-pancreatic-cancer-detection
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reposted by
Matthias Löhr ʚїɞ
Philipp Osten
3 months ago
Vier Stunden lang ein NDR Team zugetextet, Andras Moll hat allen Unsinn rausgeschnitten und kunstvoll einen Dreiminüter daraus gebastelt.
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DAS! Rote Sofa: Medizinhistoriker Philipp Osten über 'besiegte' Krankheiten - hier anschauen
Die Geschichte der Menschheit ist auch eine Geschichte des Überlebens. Wo wüsste man das besser als im Medizinhistorischem Museum in Hamburg. Dort klärt Medizinhistoriker Philipp Osten darüber auf, we...
https://www.ardmediathek.de/video/das-rote-sofa/medizinhistoriker-philipp-osten-ueber-besiegte-krankheiten/ndr/Y3JpZDovL25kci5kZS9kZmQwMGU0Yi1mMjA5LTRhZWUtYTM4OC1lZjg2NmNkNWYzMDg
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reposted by
Matthias Löhr ʚїɞ
Pancreatic Cancer Europe
3 months ago
As we continue sharing key chapters from the Treatment Opportunities and Pancreatic Cancer booklet, we now focus on Chapter 5: Supportive and palliative care. 🏥 👉 Download the resources to learn more:
https://pancreaticcancereurope.eu/project/treatment-opportunities-for-pancreatic-cancer-project/
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Some (more) light at the end of the tunnel
add a skeleton here at some point
3 months ago
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
4 months ago
Applications for UEG Summer School 2026 are opening in one week, on January 15 – mark your calendar and get ready! 🆕 New for 2026: Extended to three full days for even more practical training and collaboration 📍 11 – 14 June, Prague, Czech Republic 🔗 Learn more:
https://bit.ly/3qTAD6C
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Today, I leave as the president of
@myueg.bsky.social
It was a pleasure to serve our federation "onwards & upwards"! Handover of office was during
#UEGWeek
;
@joostphdrenth.bsky.social
was a phantastic vice president and will serve as an excellent president! This is the last
#selfiewiththepresident
4 months ago
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We are proud that our comment on the future of
#treating
#pancreaticexocrineinsufficiency
with
#pancreatin
will be the opening article for
@natrevgastrohep.nature.com
in 2026!
doi.org/10.1038/s415...
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The future of treating pancreatic exocrine insufficiency - Nature Reviews Gastroenterology & Hepatology
Patients with pancreatic exocrine insufficiency are treated with pancreatic enzyme replacement therapy. However, there are several challenges facing the future of this treatment, including infectious ...
https://doi.org/10.1038/s41575-025-01150-z
4 months ago
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This
#grandchallege
#PANORAMA
study was part of our
#PANCAIM
🇪🇺 project led by
@radboudumc.bsky.social
add a skeleton here at some point
5 months ago
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1
reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
5 months ago
Today is International Volunteer Day – and the perfect moment to say a big THANK YOU to our wonderful volunteers. Your dedication, passion, and support make everything we do possible. We couldn’t do it without you!
@maloehr.bsky.social
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Today is the day!
add a skeleton here at some point
5 months ago
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reposted by
Matthias Löhr ʚїɞ
PANCAID
5 months ago
📺 Happening now!
@scienceinnovation.ec.europa.eu
is hosting "Advancing cancer care: personalised treatment and innovation" Prof. Klaus Pantel is panelist in the session "From Detection to Decision: Cutting-Edge Diagnostics in Precision Cancer Care." 👉 Watch here:
www.youtube.com/live/z3qA1nQ...
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Advancing cancer care: personalised treatment and innovation (part I)
YouTube video by EU Science & Innovation
https://www.youtube.com/live/z3qA1nQwDCk?si=l5_akw3J-lyArE7U&t=3510
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Today on
#givingtuesday
make gift 🎁 for
#pancreaticcancer
research to
@ki.se
we need all the support, not only but also finacially 💰 that we can get. Donators will be named, as documented in our publications 📄!
5 months ago
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reposted by
Matthias Löhr ʚїɞ
Nature
5 months ago
Obituary: David Baltimore (1938-2025) virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
go.nature.com/443Vojo
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David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.
https://go.nature.com/443Vojo
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reposted by
Matthias Löhr ʚїɞ
NEJM AI
5 months ago
Perspective by Richard K. Leuchter, MD, William B. Turner, BA, and David Ouyang, MD: Evaluating Translational AI: A Two-Way Moving Target Problem
nejm.ai/3LFovDj
#AI
#MedSky
#MLSky
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3
1
reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
5 months ago
New online! The 3 Ps of IBD today — prevention, pre-diagnosis and participation
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The 3 Ps of IBD today — prevention, pre-diagnosis and participation
Nature Reviews Gastroenterology & Hepatology, Published online: 28 November 2025; doi:10.1038/s41575-025-01157-6In summary, 2025 has seen a shift in focus from pure therapeutic management to active disease prevention. The message is unambiguous. The next breakthrough in IBD will not emerge solely from new drugs or biologics, but from reimagining how we live, eat and engage with the microbial ecosystems that define our health.
https://www.nature.com/articles/s41575-025-01157-6?utm_source=bluesky&utm_medium=social&utm_campaign=nrgastro
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Another
#selfiewiththepresident
with the president of the Turkish Gastroenterology Society
#TSG
#mehmetcindoruk
in Antalya 🇹🇷 Excellent science!
5 months ago
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Thanks for pointing out our
#PANORAMA
study from
#PANCAIM
@euprojectpulse.bsky.social
This is the future of
#pancreaticcancer
#earlydetection
! Published in
@thelancet.com
oncology
add a skeleton here at some point
5 months ago
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One of the most pressning issues the
@myueg.bsky.social
is prominently and continuously addressing!
add a skeleton here at some point
5 months ago
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reposted by
Matthias Löhr ʚїɞ
Nature
5 months ago
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results
go.nature.com/3MaSKC9
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‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.
https://go.nature.com/3MaSKC9
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reposted by
Matthias Löhr ʚїɞ
Lesley Goodburn
5 months ago
www.clinicaltrialsarena.com/news/amorphi...
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Amorphical enrols first subject in Phase II trial of pancreatic cancer therapy
Amorphical has enrolled the first participant in a Phase II clinical trial assessing its nano-amorphous mineral-based therapy for stage IV pancreatic cancer.
https://www.clinicaltrialsarena.com/news/amorphical-first-subject-trial/
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reposted by
Matthias Löhr ʚїɞ
Deutsches Krebsforschungszentrum (DKFZ)
5 months ago
Dreaming of a career in cancer research? Join the International PhD Program at DKFZ - Germany’s largest biomedical research center. Explore
#cancerresearch
including
#cancerbiology
,
#bioinformatics
,
#epidemiology
&
#medicalphysics
. The Winter Selection is open now 👉 apply
t1p.de/hl56b
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
5 months ago
The EU agrees on the 2026 budget with €13bn for Horizon Europe 💶 Explore digestive health calls and funding opportunities from the Horizon Europe Work Programme 2026–2027 here: 🔗
https://bit.ly/4odr6Sz
The UEG Start-up Grant can support you every step of the way: 🔗
https://bit.ly/3ASF4Gq
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reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
5 months ago
Our DECEMBER ISSUE is live! Hepatic T cells, microbiome and pancreatic cancer, portal hypertension and cirrhosis, metabolic and alcohol-related liver disease and much more!
www.nature.com/nrgastro/vol...
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Writing from
#Brussels
@ec.europa.eu
where we are meeting for our 🇪🇺 project
@pancaid.bsky.social
#pancreaticcancer
is still a medical emergency!
add a skeleton here at some point
5 months ago
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Such a pleasure to lead this consortium together with
#klauspantel
from
#UKE
!
@ki.se
is participating with several departments including
#CLINTEC
,
#LIME
,
#NVS
#yvonnewengström
#niklaszethraeus
add a skeleton here at some point
5 months ago
0
1
1
reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
5 months ago
ICYMI: New online! Improving surgical treatments for hepatocellular carcinoma
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Improving surgical treatments for hepatocellular carcinoma
Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01143-yThis Review examines how advances in tumour biology, immunogenomics and graft preservation are redefining surgical management of hepatocellular carcinoma. Malik et al. describe the shift from anatomical to biology-informed paradigms to individualize surgical decision-making.
https://www.nature.com/articles/s41575-025-01143-y?utm_source=bluesky&utm_medium=social&utm_campaign=nrgastro
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And still continuing! In the series
#selfiewiththepresident
here with
#melindabellin
, President of the
#americanpancreaticassociation
#APA
during their annual meeting in
#sandiego
🇺🇸. Excellent, meeting with old friends and making new friends
5 months ago
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Please read "The future of treating pancreatic exocrine insufficiency" in
@natrevgastrohep.nature.com
following the
@myueg.bsky.social
- guidelines on
#pancreaticexocrineinsufficiency
, published in
#UEGJournal
. In short, we should search for non-porcine alternatives for
#PERT
.
rdcu.be/ePxW0
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The future of treating pancreatic exocrine insufficiency
Nature Reviews Gastroenterology & Hepatology - Patients with pancreatic exocrine insufficiency are treated with pancreatic enzyme replacement therapy. However, there are several challenges...
https://rdcu.be/ePxW0
5 months ago
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Join the best team in association management in Europe!
add a skeleton here at some point
6 months ago
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reposted by
Matthias Löhr ʚїɞ
Marc Besselink
6 months ago
Wonderful 2nd BCIPCC meeting
#Lisbon
🇵🇹 ⏩️
bcipcc.org
Today included
#ISGPS
and
#Robot
#Pancreatic
#Surgery
sessions: ✅
#ISGPS
is working on improved and simplified definitions for DGE and PPH ✅
#DIPLOMA3
trial Robot vs Lap Pancreatectomy is ongoing!
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