Matthias Löhr ʚїɞ
@maloehr.bsky.social
📤 485
📥 144
📝 181
Professor of Gastroenterology at
#Karolinska
Institutet.
#Pancreas
lover.
reposted by
Matthias Löhr ʚїɞ
NEJM.org
5 days ago
In a phase 3 trial, obexelimab led to a lower risk of disease flares than placebo among patients with IgG4-related disease. Glucocorticoid use was lower and the incidence of remission was higher with obexelimab than with placebo. Full INDIGO trial results: https://nej.md/4fKYQG4
#EULAR2026
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Matthias Löhr ʚїɞ
Let's Win Pancreatic Cancer
4 days ago
Daraxonrasib, the first KRAS drug for pancreatic cancer, is now available through an expanded access program, but your physician must apply for you. https://bit.ly/4uWZ9C5
#OncSky
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Accessing Daraxonrasib: A Quick Primer
Daraxonrasib, the first KRAS drug for pancreatic cancer, is now available through an expanded access program.
https://bit.ly/4uWZ9C5
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Story #1 is message #1 @pancreaticcancer
add a skeleton here at some point
4 days ago
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reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
17 days ago
ICYMI: New online! Identifying MASLD patient eligibility for pharmacological therapy: the need to integrate evidence into clinical practice
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Identifying MASLD patient eligibility for pharmacological therapy: the need to integrate evidence into clinical practice
Nature Reviews Gastroenterology & Hepatology, Published online: 20 May 2026; doi:10.1038/s41575-026-01214-8Metabolic dysfunction-associated steatotic liver disease is a leading cause of chronic liver disease, with rising liver transplantation rates. New therapies such as resmetirom and semaglutide mark a shift in treatment. However, identifying suitable patients remains challenging, requiring integrated approaches combining fibrosis stage, metabolic factors and non-invasive tools in real-world practice.
http://dlvr.it/TSfngs
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
16 days ago
Screening can help reverse the rising trend of digestive cancers across Europe – but only if it reaches everyone. Zorana Maravic from
@digestivecancerseu.bsky.social
calls for urgent action to raise awareness, increase uptake & close the access gap:
https://bit.ly/4mYFleR
#DigestiveHealthMonth
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
16 days ago
Did you know Gutflix has bookmarks? 🔖 Build your 'study later' list 🔖 Pick up where you left off 🔖 Save what matters to your practice Bookmark your favourite content today:
https://gutflix.eu/
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Demonstrating one more time the importance of the
#centralorgan
So-called “sympathetic” reaction
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22 days ago
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Very nice review by world renowned experts!
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22 days ago
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Excellent Chance to raise your Level of Expertise and increase your Network!
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22 days ago
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reposted by
Matthias Löhr ʚїɞ
European Research Council (ERC)
24 days ago
Are you a researcher based in the USA 🇺🇸 or Canada 🇨🇦 interested in pursuing curiosity-driven research in Europe? Join the ERC and Euraxess for a webinar exploring ERC funding opportunities. 👇️ 📅 20 May 2026 🕚 11:30 AM ET | 8:30 AM PT 💻 Online Find out more and register:
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ERC Grants Info Session: Funding for Excellent Frontier Research
Join EURAXESS North America and the European Research Council Executive Agency for a webinar on the bottom-up funding schemes that make up the European Research Council grants. The ERC is the premier…
https://buff.ly/1hhRqTG
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reposted by
Matthias Löhr ʚїɞ
Pancreatic Cancer Europe
26 days ago
🟣 Did you know? Your pancreas produces about 1.5 litres of digestive juices every day to help break down proteins, fats, and carbohydrates in your food. This powerful little organ is working hard behind the scenes every time you eat. 🔗 Learn more:
https://pancreaticcancereurope.eu
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reposted by
Matthias Löhr ʚїɞ
Pancreatic Cancer Europe
about 1 month ago
Yesterday at the
#DISCERN
Annual Meeting, PCE Chairperson Alfredo Carrato joined a roundtable on patient advocacy in cancer research. The message was clear: clinical trials must meet patients where they are, emotionally and humanly. Patient voice isn't commentary, it's evidence.
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A wuestion asked by patients and to be answer by doctors …
@pancaid.bsky.social
add a skeleton here at some point
29 days ago
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Most of the work 📄 eventually being awarded with a
#nobelprize
was done by scientists 👩🔬 in their thirties
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about 1 month ago
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reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
about 1 month ago
ICYMI: New online! Cirrhosis, portal hypertension and hepatocellular carcinoma: a stage-based approach
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Cirrhosis, portal hypertension and hepatocellular carcinoma: a stage-based approach
Nature Reviews Gastroenterology & Hepatology, Published online: 06 May 2026; doi:10.1038/s41575-026-01209-5Cirrhosis, portal hypertension and hepatocellular carcinoma (HCC) are interconnected but are often addressed separately. This Review outlines the key interactions between portal hypertension and HCC in cirrhosis, and explores the management of these conditions across all stages, proposing an integrated, stage-based management framework.
http://dlvr.it/TSQm4K
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
about 1 month ago
👩👧Maternal #MASLD increases risk of serious infections in offspring Swedish nationwide cohort: 🔸 Overall risk ↑ (aHR 1.81) 🔸 Highest in infancy (aHR 3.11) 🔸 Risk persists up to 31 yrs Read the article in UEG Journal: 👉
https://bit.ly/4uhhWYC
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
about 1 month ago
Reducing digestive cancer mortality starts even before treatment – with stronger prevention and screening. Hear from Thomas Seufferlein from ESDO on the key actions needed to move digestive cancer prevention forward 👉
https://bit.ly/4mYFleR
#DigestiveHealthMonth
#EUNewsline
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
about 1 month ago
📊 Digestive diseases and cancers place significant pressure on public health systems and economies across Europe, with findings from the White Book 2 showing that incidence, prevalence and mortality rates have been rising since 2000. Further insights in the thread below ⬇️
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Wry important! See also
#PANCAIM
publication of
#PANORAMA
study led by
@radboudumc.bsky.social
and
@ki.se
published in
@thelancet.com
add a skeleton here at some point
about 1 month ago
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reposted by
Matthias Löhr ʚїɞ
Seifert Lab
about 1 month ago
New publication in
@annsurgoncology.bsky.social
! 🎉 We show that low preoperative sCD40 serum levels are significantly associated with key complications after
#PancreaticSurgery
. 📄 Read the full paper here:
link.springer.com/article/10.1...
#ClinicalResearch
#Surgery
#RiskPrediction
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Very important to raise that level!
add a skeleton here at some point
about 1 month ago
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
about 1 month ago
⚠️Motorized #SpiralEnteroscopy shows higher risk vs #BalloonEnteroscopy Based on >12,500 procedures across 68 studies: 🔸Adverse events: 10.8% vs 1.6% 🔸Serious adverse events: 1.5% vs 0.4% 🔸More esophageal injury & perforation Read the full article in UEG Journal: 👉
http://bit.ly/4caHVut
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
about 1 month ago
#DigestiveHealthMonth starts today 💚 This May, we’re putting prevention front and centre: tackling digestive diseases and cancers through the lens of nutrition and digestive cancer screening 🥗🔍 Find out more and follow along 👉
https://bit.ly/4iN57Ps
#DigestiveHealthMonth
#EUNewsline
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
about 1 month ago
One EU plan. Two major health challenges. But what does the EU Safe Hearts Plan have to do with digestive health? Join our 7 May webinar to connect the dots – and uncover shared opportunities for prevention 🌍 Register 👉
https://bit.ly/4tYNGBB
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reposted by
Matthias Löhr ʚїɞ
Nature
about 1 month ago
🚨🚨 Good news alert! 🚨🚨 We've rounded up five inspiring science stories – including the discovery of a new species, and a promising medical treatment for a fatal mitochondria disease.
go.nature.com/4d0b1vG
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The news is not all bad: Five inspiring science stories to lift your mood
Species recovery, cancer-preventing vaccines and progress in developing renewable-energy sources are just some of the positive developments that have happened this year so far.
https://go.nature.com/4d0b1vG
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reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
about 1 month ago
ICYMI: New online! γδ T cells in colorectal and liver cancer
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γδ T cells in colorectal and liver cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 22 April 2026; doi:10.1038/s41575-026-01196-7γδ T cells are an important component of local immune surveillance. This Review discusses their role in colorectal cancer and hepatocellular carcinoma development and provides a detailed overview of their therapeutic potential.
http://dlvr.it/TSGXQ8
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Raising awareness for
#pancreaticcancer
during
#masterclass
held by
@pce-europe.bsky.social
in
#Malta
, sponsored by the Ministry of Health
#JoEtienneAbela
@nuriamalats.bsky.social
about 1 month ago
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reposted by
Matthias Löhr ʚїɞ
Lesley Goodburn
about 1 month ago
www.roswellpark.org/newsroom/202...
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New Research Sheds Light on How Precancerous Lesions Form in the Pancreas
Research is significant for future prevention and early detection of pancreatic cancer
https://www.roswellpark.org/newsroom/202604-new-research-sheds-light-how-precancerous-lesions-form-pancreas
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reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
about 2 months ago
ICYMI: New online! The critical role of gut–brain signalling in eating behaviour and obesity
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The critical role of gut–brain signalling in eating behaviour and obesity
Nature Reviews Gastroenterology & Hepatology, Published online: 21 April 2026; doi:10.1038/s41575-026-01203-xThis Review outlines the role of gut–brain signalling in eating behaviour and obesity, highlighting gut-derived signals and cues relevant during eating phases. Underlying mechanisms of this gut–brain communication are discussed alongside the key role of the vagus nerve in this process.
http://dlvr.it/TSB37v
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An honor to be Part of it!
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about 1 month ago
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reposted by
Matthias Löhr ʚїɞ
JAMA
about 1 month ago
Viktor Ahlqvist, PhD, from the Karolinska Institutet joins JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss why automated drug safety surveillance during
#pregnancy
is urgently needed and how
#AI
and
#computation
can strengthen or undermine causal inference.
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AI Drug Safety in Pregnancy
JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, spoke with Viktor H. Ahlqvist, PhD, a postdoctoral fellow in the Unit of Integrative Epidemiology of the Institute of Environmental Medicine a...
https://jamanetwork.com/journals/jama/fullarticle/2848121?guestAccessKey=e4a0ac62-eb49-43e2-94ec-2f43d6d20bcf&utm_source=twitter&utm_medium=social_jama&utm_term=20264305552&utm_campaign=article_alert&linkId=932051202
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reposted by
Matthias Löhr ʚїɞ
Karolinska Institutet
about 2 months ago
Addressing iron status may be relevant for
#dementia
prevention and healthy
#ageing
, suggests a KI study published in BMC Medicine
@bmc.springernature.com
. Both absolute and functional iron deficiency were linked to higher dementia risk in older adults. 🧪
#aging
doi.org/10.1186/s129...
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Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS - BMC Medicine
Background Iron deficiency (ID) is proposed to be involved in cognitive aging and dementia; however, empirical data is lacking to support this hypothesis. We examined the association between absolute and functional ID and incident dementia diagnosis. Methods Data from 70,935 individuals aged ≥ 50 years from the Swedish AMORIS cohort, who had blood measurements indicative of iron status between 1985–1996, were used. Participants were followed for incident dementia diagnosis recorded in National Patient Register (inpatient and specialist outpatient) and Prescribed Drug Register (dispensed anti-dementia drugs) for up to 15 years. Two exposure groups were defined: absolute iron deficiency (serum ferritin < 30 ug/L) and functional iron deficiency (transferrin saturation < 20% and serum ferritin ≥ 30 ug/L). The reference group included individuals with measurements in the normal range of hemoglobin, serum iron, and total iron binding capacity. Results A total of 4,994 individuals received a dementia diagnosis over a mean of 12.6 years. Compared with the reference group, absolute and functional ID was associated with increased dementia diagnosis (adjusted hazard ratio (HR) = 1.24, 95% confidence interval (CI): 1.18–1.42; HR = 1.21, 95% CI: 1.05–1.39, respectively), after adjusting for age, sex, education, and comorbidities. The associations were essentially consistent across subgroups, and when further adjusting for kidney function, body mass index, and smoking in subsamples. Conclusions Even though absolute and functional iron deficiency has different underlying mechanisms, we found that both conditions are associated with an increased risk of dementia. Considering that iron deficiency is a pervasive but often neglected health issue in older adults, resolving iron deficiency may be relevant for dementia prevention.
https://doi.org/10.1186/s12916-026-04839-3
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💡 Pancreatic exocrine insufficiency (PEI) is common, yet frequently unrecognised. PEI is a common driver of malnutrition. PEI is a maldigestion syndrome that demands a structured, context-driven approach.
@myueg.bsky.social
🔗 Access the full article on Gutflix:
bit.ly/4mDbeJF
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Mistakes in Pancreatic exocrine insufficiency and how to avoid them
Pancreatic exocrine insufficiency (PEI) is a common yet frequently under-recognised cause of maldigestion, malabsorption, and malnutrition. Although traditio...
https://bit.ly/4mDbeJF
about 2 months ago
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reposted by
Matthias Löhr ʚїɞ
PANCAID
about 2 months ago
Detecting cancer early can dramatically improve outcomes. This week's glossary carousel explains: • Diagnosis • Screening • Early detection These concepts are central to ongoing research aimed at improving survival rates for pancreatic cancer.
#EarlyDetection
#CancerAwareness
#PancreaticCancer
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Following the
#guidelines
for
#pancreaticexocrineinsufficiency
supported by
@myueg.bsky.social
@uegj.bsky.social
, we put together a review covering the important aspects, now published in a
@elsevierconnect.bsky.social
journal,
@eclinicalmed.bsky.social
authors.elsevier.com/sd/article/S...
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ScienceDirect.com | Science, health and medical journals, full text articles and books.
https://authors.elsevier.com/sd/article/S2589537026001276
about 2 months ago
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reposted by
Matthias Löhr ʚїɞ
Lesley Goodburn
about 2 months ago
medicalxpress.com/news/2026-04...
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Reprogramming regulatory T cells could help immunotherapy work in pancreatic cancer
Researchers at Oregon Health & Science University have uncovered a key reason why immunotherapy has largely failed in pancreatic cancer—and identified a promising strategy to overcome that resistance....
https://medicalxpress.com/news/2026-04-reprogramming-regulatory-cells-immunotherapy-pancreatic.html
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reposted by
Matthias Löhr ʚїɞ
United European Gastroenterology
about 2 months ago
🥗 Sucrase-isomaltase variants do not influence #FODMAP diet outcomes in #IBS 🔸 54% carried ≥1 hypomorphic SI variant 🔸 Initial & long-term diet response similar across genotypes 🔸 Dietary intake unaffected by carrier status Read more in UEG Journal: 👉
https://bit.ly/4vhwxoj
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This is the way to go! As we are doing w/
@pancaid.bsky.social
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about 2 months ago
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KRAS G12D - that’s the one for
#pancreaticcancer
!
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about 2 months ago
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reposted by
Matthias Löhr ʚїɞ
Lesley Goodburn
about 2 months ago
www.mdanderson.org/newsroom/res...
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Researchers find new target to sensitize pancreatic tumors to immunotherapy
Researchers find new target to sensitize pancreatic tumors to immunotherapy
https://www.mdanderson.org/newsroom/research-newsroom/researchers-find-new-target-to-sensitize-pancreatic-tumors-to-immunotherapy.h00-159854556.html
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reposted by
Matthias Löhr ʚїɞ
Pancreatic Cancer Europe
about 2 months ago
PCE is pleased to introduce Patrycja Rzadkowska, Patient & PCE Vice Chair, Poland for the upcoming masterclass: Patrycja will share insights on supporting patients in the disease process, emphasising patient-centred care. 📅 Monday, 27 April 2026 🕒 13:45 – 17:00 CEST 📍 Grand Hotel Excelsior Malta
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reposted by
Matthias Löhr ʚїɞ
Karolinska Institutet
about 2 months ago
Gut bacteria appears linked to how much latent
#HIV
remains in the blood during antiretroviral therapy, a study in Gut Pathogens shows. Findings suggest the gut
#microbiome
may influence how much virus persists in the body 🧪
news.ki.se/gut-bacteria...
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reposted by
Matthias Löhr ʚїɞ
Pancreatic Cancer Europe
2 months ago
On
#WorldHealthDay
, we are reminded that health is a fundamental right, yet for many people affected by pancreatic cancer, timely diagnosis, access to treatment, and quality care remain out of reach. Today, we stand united to change that. 🌍💜
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reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
2 months ago
ICYMI: New online! Pathophysiology of colitis-associated colorectal cancer
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Pathophysiology of colitis-associated colorectal cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 01 April 2026; doi:10.1038/s41575-026-01197-6In this Review, Neufert and Neurath discuss the pathophysiological mechanisms of colitis-associated colorectal cancer, focusing on the tumour epithelium, stromal cells, mucosal barrier and mechanisms of tumour development. They also discuss potential implications for personalized therapy.
http://dlvr.it/TRwGmG
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reposted by
Matthias Löhr ʚїɞ
Nature Reviews Gastroenterology & Hepatology
2 months ago
New online! The microbiome regulates host metabolic health and diseases through microbial enzymes
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The microbiome regulates host metabolic health and diseases through microbial enzymes
Nature Reviews Gastroenterology & Hepatology, Published online: 07 April 2026; doi:10.1038/s41575-026-01195-8In this Review, Jiang and colleagues describe how gut microbial enzymes regulate host metabolic health and diseases. They also discuss the methodology for studying gut microbial enzymes and their potential clinical applications.
http://dlvr.it/TRwk31
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Important Meeting to raise awareness for
#pancreaticcan
er
add a skeleton here at some point
about 2 months ago
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reposted by
Matthias Löhr ʚїɞ
JAMA
about 2 months ago
📊 JAMA Clinical Guidelines Synopsis: #CrohnDisease guidelines recommend fecal calprotectin for screening and monitoring, routine colonoscopy for colorectal cancer, and oral budesonide for induction in mild to moderate ileocecal disease.
ja.ma/47QA5ng
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reposted by
Matthias Löhr ʚїɞ
wemeze
2 months ago
#wemezeclassics
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reposted by
Matthias Löhr ʚїɞ
Let's Win Pancreatic Cancer
2 months ago
Sending love and hope to the Let's Win community this Easter. 💜
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reposted by
Matthias Löhr ʚїɞ
WHO
3 months ago
Women play a vital role in science. A powerful reminder from mRNA researcher and Nobel Prize winner Prof. Katalin Karikó on why science needs more women!
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