plantiSMASH 2.0: improvements to detection, annotation, and prioritization of plant biosynthetic gene clusters https://www.biorxiv.org/content/10.1101/2025.10.28.683968v1

Excited to see our paper online! We combined scMS and scRNA-seq from the same plant cells 🌱 — a step toward true single-cell multi-omics in plants. Overview 👇

Very exciting to finally see our iridoid cyclase ICYC online @natplants.nature.com! A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment. #natprod #PlantScience @mpi-ce.bsky.social www.nature.com/articles/s41...

Super excited to introduce our recent work published in @natprot.nature.com today. Here we introduce a step-by-step protocol for applying multiple data analysis workflows in GNPS2 for drug metabolism studies. www.nature.com/articles/s41...

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics #Cell #MassSpec www.cell.com/cell/fulltex...

Here, the authors @oconnorlab.bsky.social @mpi-ce.bsky.social uncover the mechanism of epimerization behind uncommon 3R-containing alkaloids in Mitragyna speciosa (Kratom) and study their inclusion in downstream biosynthesis #PlantScience #natprod www.nature.com/articles/s41...

Withanolide #biosynthesis from nightshade plants decoded. Withanolide steroids are used as a basis for medications for centuries. Now published by a team around @frankelab.bsky.social + @puckerlab.bsky.social in @natcomms.nature.com (DOI: 10.1038/s41467-025-61686-1).

New Article: "High-temperature-induced FKF1 accumulation promotes flowering through the dispersion of GI and degradation of SVP" rdcu.be/evfAY GI forms an inactive nuclear condensate that is dispersed at high temperatures by FKF1 binding to GI’s disordered region.

Plant Science Research Weekly -- Artificial condensates can boost metabolic engineering (Plant Biotechnol. J.) @leesweetlove.bsky.social‬ @anyalb.bsky.social‬ (Summary by Ciara O’Brien @ciara_obrien.bsky.social) buff.ly/Y5wFnGv #PlantaePSRW

Lead author @matildeflorean.bsky.social‬ et al. from the @oconnorlab.bsky.social discover a "fake" enzyme in plants that enables the formation of free indole, a key molecule for defense & attracting pollinators. www.ice.mpg.de/496511/PR_Fl...

This is a must-read for everyone involved in metabolomics. Personally I love this article because I no longer have to write a long paragraph when I say 'please don't use pathway analysis' during peer review 🤣

Finally online and open access! This revised version has a slightly different title and contains a number of additional supplementary figures, mainly in vitro enzyme assays. Kept me quite busy in the lab at the end of last year! #PlantScience #natprod www.nature.com/articles/s41...

A new paper reports a plant chassis for high-yield isoflavonoid production, leading to the identification of six P450s that complete the 15-step biosynthesis of diverse glyceollins, which are critical compounds for plant defense www.nature.com/articles/s41...

Excited to share my new Tansley Review @newphyt.bsky.social on emerging single-cell and spatial omics technologies, many of which are just beginning to be applied in plant biology! Big opportunities lie ahead for the field. [1/n]  nph.onlinelibrary.wiley.com/doi/10.1111/...

Convergent evolution of "smelling like rotting meat" is mediated by a 3 amino-acid chance in a conserved enzymes, just out @science.org 🔽 www.science.org/doi/10.1126/...

Our work on Taxol biosynthesis is now out at @natsynth.nature.com. You can read it here: www.nature.com/articles/s44...