Why do some people lose memory faster with age? A mega-analysis of 13 longitudinal datasets (3,700+ adults, 10,000+ MRIs) shows that memory decline tracks brain atrophy, especially in the hippocampus, and that these links strengthen with age, but not APOE status: www.nature.com/articles/s41...

Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change www.nature.com/articles/s41...

" Our mega-analysis reveals a nonlinear relationship between memory decline and brain atrophy, primarily affecting individuals with above-average brain structural decline. "

Very impressed with @didacvp.bsky.social's work in @natcomms.nature.com, the most thorough mapping of longitudinal memory-atrophy relationships in normal aging, showing both global and memory-specific associations, which grow stronger with age. Early accsess here: www.nature.com/articles/s41...

Impressive MEGA-analysis: Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change www.nature.com/articles/s41...

Thanks for the fun and interesting discussions @kathrynbates.bsky.social and Chloe Carrick

Over 12,500 brain scans from cognitively healthy adults reveal that sex differences in age-related brain atrophy can’t explain why women have higher rates of Alzheimer's disease. The authors call for research into alternative explanations. In PNAS: https://ow.ly/hIYj50XgiCn

It is this type of sky over the university. Morning office window view.

@nature.com made a news piece on our new @pnas.org paper. Good job Anne Ravndal! Men’s brains shrink faster than women’s: what that means for Alzheimer’s. www.nature.com/articles/d41...

Another interesting paper from LifeBrain consortium suggesting that sex differences in healthy brain aging are unlikely to explain higher prevalence of Alzheimer’s disease in women www.pnas.org/doi/10.1073/...

@pnas.org: Small sex differences in brain aging, steeper decline in men in some regions. Does not explain why more women are diagnosed with AD. 12,638 longitudinal MRIs, 4,726 participants across 14 cohorts. Control for head-size, education, life-expectancy. www.pnas.org/doi/10.1073/...

Using 4570 longitudinal MRIs + 1684 Aβ PET scans from cognitively healthy older adults @jamesmroe.bsky.social find cortical thickness changed ≥7 years before PET-detectable Aβ. Those who later developed high Aβ already had thicker cortex & less thinning. @LCBC_uio www.biorxiv.org/content/10.1...

🧠 Education boosts memory levels but not brain aging resistance A new study across 33 countries found more education links to better memory and larger brain volume, but not slower cognitive or brain decline. 🔗 www.nature.com/articles/s41... #SciComm 🧪

@natmed.nature.com made a nice Research Briefing about our paper. Highglights with less details, the main conclusion is the same: Education does not affect memory decline or brain aging @LCBC_UiO @LifebrainEU www.nature.com/articles/s41...

🧠💡 CAN YOU SAVE YOUR FUTURE BRAIN BY GETTING A DEGREE? A new Nature Medicine paper—led by @andersfjell.bsky.social—analyzed 407,000 memory tests and 15,000 brain scans across 33 countries to find out whether education protect you from cognitive decline at older ages. The answer: not really. [1/5]

New in @NatureMedicine Education is not linked to slower memory or brain decline in aging. We analyzed 400,000 memory tests and 15,000 MRIs from 33 countries. Associations likely shaped by childhood schooling and development. @LCBC_UiO @LifebrainEU rdcu.be/ex8iC

New paper by @njudd.com shows that an additional year of education doesn't causally affect telomere length in old age, despite many (theory) accounts arguing otherwise. It's been desk rejected by 13 journals happy to publish small 'positive' telomere studies. Sigh. www.biorxiv.org/content/10.1...

This is a really interesting paper - showing what you can and cannot infer about individual differences in change from x-sect data. A take-home-message is that typical brain age models cannot be used to measure differences in brain aging - deviations reflect stable differences between people.

Preprint: before age 60, between-people diffs in brain vols almost exclusively reflect stable diffs, while systematic diffs in rate-of-change in aging cause up to 40% of the variation to be due to change at 80 years. @edvardg.bsky.social 🧵https://www.biorxiv.org/content/10.1101/2025.05.26.655710v1

Very nice in @pnas.org - people who slept closer to their own culture's norms for sleep duration had better overall health. Sleep duration is more complex than often considered in a strict neuroscientific or biomedical sense. @ChristineOuBC @stevenheine.bsky.social www.pnas.org/doi/10.1073/...

This is a great centre (and a great city), very good opportunity 👇

A balanced discussion in @nature on the possible role of sleep for waste clearance, with both sides presenting their arguments. What is lacking is a stronger focus on how the evidence looks in humans - so far it is not particularly strong. www.nature.com/articles/d41...

Very interesting from @VidalDidac - MUCH higher reliability for structural neuroimaging measures with longer follow-up time rather than more follow-ups or higher n. 2.-year follow-up requires 4 times higher n than 6-year follow up. @LCBC_UiO direct.mit.edu/imag/article...

Did you know that different prenatal environment causes MZ twins' brains to deviate? But when exposed to cognitive intervention in adulthood, common genetics make their brains converge while DZ twin brains become more different. Fascinating! @LCBC_UiO www.biorxiv.org/content/10.1...

Preprint from @didacvp.bsky.social - a common brain factor underlying memory decline in older age. Stronger associations in older, but independent of genetic Alzheimer risk. Very interesting work using >10.000 MRI scan. @LCBC_UiO www.biorxiv.org/content/10.1...

Open Postdoctoral position! - ERC Advanced Grant project HOMME www.jobbnorge.no/en/available-jobs/job/276000/postdoctoral-fellow About the HOMME project www.sv.uio.no/psi/english/research/projects/homme

We find hippocampal correlates of superior episodic memory are the same across adulthood - we don't find evidence that special hippocampal features are important in aging across memory activity, macrostructure, microstructure and atrophy. rdcu.be/edvSC

This is the coolest preprint I have been a (small) part of: twins cybercycling in virtual reality to demonstrate how early and later environmental influences on the cortex can be distinguished and modified. www.biorxiv.org/content/10.1...

This is the coolest preprint I have been a (small) part of: twins cybercycling in virtual reality to demonstrate how early and later environmental influences on the cortex can be distinguished and modified. www.biorxiv.org/content/10.1...

Really interesting from @maxwellelliott.bsky.social et al: 1-year brain changes reliably detected by cluster-scanning - burst of multiple, very short T1's. Great potential for tracking individual differences in brain change over clinically meaningful intervals. www.medrxiv.org/content/10.1...

New paper: neural segregation in development & dedifferentiation in aging associate with memory. Within & between-network FC during encoding and retrieval, 2 samples, 7-82 years, n=734, using a multiverse approach. Lead by Håkon Grydeland 👏 @LCBC_UiO www.sciencedirect.com/science/arti...

Enjoyable read in @brain1878.bsky.social by Tom Pollak against "inflammatory reductionism" in psychiatry, and in favour of ‘tolerance of ambiguity’ - the extent to which an individual can cope without certainty. academic.oup.com/brain/articl...

Review: 85% of 27.5k participants rated sleep as important/ very important for brain health. But the evidence for a causal role of sleep is surprisingly weak relative to the amount of attention to sleep in science and society. @KWalhovd journals.sagepub.com/doi/10.1177/...

Preprint: Why is edu associated with better memory in aging? We used >400k memory tests & 15k brain MRIs: (1) Edu linearly related to memory, larger ICV & (slightly) larger vol in memory regions, (3) not less decline (mem+brain), (4) not enhanced tolerance to atrophy.🧵 medrxiv.org/cgi/content/...

If you are in Norway: Hosting a seminar on changing cognition - over time and over the lifespan. Feb 13th at 17.00 downtown Oslo. @olerogeberg.bsky.social @arnovanhootegem.bsky.social @PabloFGarrido @UiO_Lifesci www.uio.no/om/aktuelt/u...

Just reviewed for Mechanisms of Aging and Development, a respected journal w. IF>5, and found this in the acceptance letter: "This recommendation is primarily based on your esteemed standing in the academic community, rather than on the overall quality of the manuscript itself." What can you say?

Just out: We find that change in AD-sensitive brain features correlates with genetic AD-risk and memory decline in healthy adults. Furthermore, most older adults show accelerated decline in AD regions, related to episodic memory decline. Lead by James Roe. www.nature.com/articles/s41...

Christmas lunch at LCBC

This looks pretty cool - a "next generation" histological atlas of the human brain applied to automated brain MRI. Will check out on own data for sure! www.biorxiv.org/content/10.1...