This is from The Tonight Show with Johnny Carson aired on May 20th, 1977. Carl Sagan says something very important, a strong message that didn't lose any validity since then.

We’ll know open science has truly gone mainstream once OSF @cos.io beats the Old Spaghetti Factory in the search results.

This is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.

What it's like inside the NIH under current conditions: not good. Terrible uncertainty and low morale, and an inability to order even basic materials because of trouble with the purchasing department:

✨Symposium session reveal✨ Featuring @albertantolin.bsky.social and @karmencj.bsky.social, this session highlights initiatives enabling communities to come together to solve some of the biggest challenges in drug discovery. Register here: conscience.ca/symposium2025

We are uniting experts in ML, computational chemistry, and drug discovery to get hands-on experience with AIRCHECK. Co-developed by SGC and @uhntoronto.bsky.social, AIRCHECK is an open data platform designed to enhance predictive models in drug discovery. event.fourwaves.com/aircheckwork...

I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War. Same link, new title and some updates.

More than 25 years after FXR agonist GW4604 was described by now @thesgc.bsky.social scientist Tim Willson, it is still being used in cutting edge papers. High quality #ChemicalProbes are expensive to discover, but they’re the gift that keeps on giving. www.nature.com/articles/s41...

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...

They said it, we didn’t. 👀 boingboing.net/2025/01/28/s...

While we gear up to welcome both Polaris and ASAP to our Symposium in April, they have been cooking up something special. They're releasing an intermediate leaderboard for the antiviral challenge on the 31st. So you (looking at #CACHEChallenge participants!) have a few days to get in a prediction!

📣 We heard your feedback! We’ll be putting all results submitted by Jan 31st on an intermediate leaderboard so you can see how you rank across other participants in the antiviral challenge. Ready to put your predictions to the test? 📨 Submit your results today: polarishub.io/competitions

Are you working to advance #OpenScience, #AI -assisted drug design, or innovative approaches to #DrugDiscovery? Submit an abstract by March 7 for the opportunity to present a 3-minute flash talk at the Conscience Symposium on Open Drug Discovery on April 7-8, 2025, in Montreal!

Interested in building the future of open source ligand- and structure-based ML models for ADMET prediction? The ARPA-H funded OMSF (@omsf.bsky.social) OpenADMET project is hiring multiple positions to build ML models of ADMET properties and drive informative data collection! openadmet.org/jobs/

Enjoyed this accessible talk by Head of Data at @asterainstitute.bsky.social and @conscience-network.bsky.social board member John Wilbanks It's the type of quality, down to earth advice and insight that only comes from decades of careful thought and really caring. www.youtube.com/watch?v=4Xnl...

MAINFRAME membership offers: - Access to high-quality training datasets - Participation in benchmarking challenges with experimental validation - Collaborative research opportunities Join a community committed to open science: aircheck.ai/mainframe

Early registration is now open for the Conscience Symposium on Open Drug Discovery in Montreal on April 7-8! To ensure accessibility for all, we're offering significantly reduced registration fees for students and Early Bird discounts until Jan 31 - don't miss out! conscience.ca/event/consci...

You didn't think we forgot about science did you? 🧬🧪 Our 2024 year in review reflections conclude with the Open Science program at CC. Read more about the work of Open Science and what's to come in 2025: loom.ly/LOfb8A8

Waking up in the morning isn't so hard when you get to work on this mission with these people.

Millions worldwide lack treatments for diseases that threaten their lives or quality of life. We believe #OpenScience is key to tackling these challenges and that we can transform #DrugDevelopment by fostering collaboration, sharing data, and prioritizing accessibility. conscience.ca/news/drug-de...

Want to learn more about what we're up to at @conscience-network.bsky.social and why we do what we do? Check out our latest blog post, written by @richardgold.bsky.social (and edited by me)! I couldn't be more proud to contribute to such a great mission. #OpenScience #DrugDevelopment

🥇 Inside the Best Paper from @neuripsconf.bsky.social FM4Science Workshop. Phil Fradkin of @valenceai.bsky.social presents MolPhenix - foundation model that predicts the effect of any given molecule & concentration pair on phenotypic cell assays & cell morphology. www.youtube.com/shorts/hpD4X...

Thank you to @neuripsconf.bsky.social for a lovely conference. You didn't have "taking off on a seaplane in a windstorm" in the agenda but I recommend it for next year. Better than 5 cups of coffee.

Finished off my time at @neuripsconf.bsky.social with another stroll round some posters. I'm not sure when we'll be simulating biology with high fidelity but it was very cool to be in the room with some of the people making that future. Till next year. AI-dios

Special delivery from @neuripsconf.bsky.social! We just released our latest certified dataset, RxRx3-core, which includes labeled images of 735 genetic knockouts & 1,674 small-molecule perturbations. The related benchmark evaluates the zero-shot prediction of compound-gene activity. #NeurIPS 👇

🛡️ New certified dataset and benchmark from @recursionpharma.bsky.social! Did you know that high-dimensional data like cell images (i.e. phenomics) can help us understand the relationship between compounds and genes? 🧵 Dataset: polarishub.io/datasets/rec... Benchmark: polarishub.io/benchmarks/r...

It is time for my favorite annual tradition: getting lightly tipsy, heading to the bookstore, pointing out 4-5 books I want to my partner, and then letting them pick one in secret for our xmas eve book exchange

The Old Testament? I think you mean The Great Begatsby

The scarcity of data - "the fossil fuel of AI" - is a big topic here at @neuripsconf.bsky.social Keynote asking what comes next after we've exhausted what we have because we have "but one internet."

CACHE #3 data is out! As in other challenges, great diversity in computational workflows, many combining physics-based and ML methods and a recurring high performer. Shoutout to our target expert, @fraserlab.bsky.social, who's lab crystallized 44 CACHE compounds. bit.ly/3D8eABU @thesgc.bsky.social

Call out to all you comp drug disc folks at @neuripsconf.bsky.social. New open science network for drug discovery just dropped by our partners at the SGC. Community, data, and benchmarks galore. Ping me here, whova, or linkedin if you want to chat about it.

I just read your profile @bmix.bsky.social "i.e. potters around"... I take off my hat to you; then I throw it on the ground and stomp on it.

Who's feeling that wierd combo of kind of overwhelmed but also excited that so often happens at large conferences? This guy! Thank you @neuripsconf.bsky.social but also maybe next time some cots and a nap room?

Very much enjoyed the presentation from Isomorphic Labs on AlphaFold 3 at #NeurIPS2024. Pretty stunning stuff. We are all battling Eroom's Law. Can't wait for them to show both proof and pudding in a #CACHEChallenge

Alright DeepMind. Ready to have mind blown by moving from structure to function. Let's go. #NeurIPS2024

Here we go for Thursday at #NeurIPS2024. Starting off with a walk through the posters. Nothing like walking past posters about ecology, archeology, neuroscience, law, and regret(?) to see how AI is present in just about every field. Now to find the comp. Bio folks and talk #CACHEChallenge

Fei-Fei Li packing the hall with her talk on Visual Intelligence at #NeurIPS2024

Registration time for #NeurIPS2024! Wearing my whitest hat to make finding me easy amongst 10k+ registrants. The eagerness is palpable. Now to get the lay of the land

Officially away on my way to Vancouver to represent @conscience-network.bsky.social at the #NeurIPS conference! Always love a seaplane ride. Excited to learn and meet the people working on all areas of #AI If you are there find me on linkedin, whova, or right here and reach out.

We're excited to work with @omsf.io OpenADMET and @polarishub.io to bring you this blind predictive modeling community challenge! If you're developing predictive models for drug discovery---potency or ADMET---here's your chance to test them prospectively on real discovery data from ASAP!

Our CACHE Challenges bring together teams from across the globe to predict molecules that will bind to a specific disease target. Their predictions are evaluated in a state-of-the-art laboratory and results are shared openly with the world. Learn more here: conscience.ca/cache-challe...

On a professional note, I'm the Comms Lead @conscience-network.bsky.social and I love working for an org that shares my values! Follow us to learn more about our mission to use #OpenScience and #AI to develop accessible medicines for those who are too often left behind, and maybe see you in April??