Great message from Jim Allison on how we need to keep doing science. Even nicer shoutout to JEM on the interplay between CTLA-4 and ICOS enhancing ICI (tinyurl.com/4rebxhuj and tinyurl.com/42fnrbvb). Attending the Keystone Immunotherapy? Come and say hi 👋 #KSCancerImmune26

For this month #JEMjc we would like to highlight this study from Eva Harris lab linking anti-NS1 IgA antibodies in plasma from a primary ZIKV infection, to drive neutrophil activation and correlate with increased risk of subsequent severe DENV2 disease. More here: www.nature.com/articles/s41...

It’s #JEM_Spotlight time again: this month we would like to highlight the detailed analysis of serological antibodies elicited after R21/Matrix-M malaria vaccine. Because, you know, vaccines work. doi.org/10.1084/jem.20241908

Happy New Year from all of us @jem.org. For this month’s #JEMLegacy we are going back to the 90s with this report on lymphotoxin’s role in chronic inflammation tinyurl.com/2ua2cezw

Congratulations to Cedars-Sinai Postdoc Katarzyna Chojnacka, winner of the JEM Early Career Travel Award to attend the #Cytokines2025 meeting in Seattle. Learn more here: rupress.org/jem/pages/ea...

Following on from a great site visit at @cicbiogune.bsky.social last week, for #JEM_Spotlight I would like to highlight the work of @arkaitzcarracedo.bsky.social. A really interesting study investigating the role of LKB1 in metastatic prostate cancer. Take a look here 👉 doi.org/10.1084/jem....

And if you needed any more convincing about the importance of #Tregs, check out this #Viewpoint written by Shimon for @jem.org's 125th anniversary about the role of Tregs in immunological self-tolerance and autoimmunity 👉 rupress.org/jem/article/...

In light of Monday’s #Nobel Prize in Physiology or Medicine announcement, for #JEMLegacy let’s look back at one of Shimon Sakaguchi’s early @jem.org papers from 1985! rupress.org/jem/article/...

For September’s #JEMjc we would like to highlight the recent description of septal macrophages controlling adipocyte tissue plasticity www.science.org/doi/10.1126/...

Back to school, back-to-back #JEMLegacy with this study of neutralization tests for poliomyelitis in newborn infants and mothers…from 1930! tinyurl.com/59nnnuan

Back to school time of year with this #JEM_Spotlight describing the γδ T cell profiling of pre-term infants as a first line of defense for neonates tinyurl.com/3hz73p2v

JEM's Deputy Editor Gaia Trincucci (@gaiajexpmed.bsky.social) and @rupress.org's Ben Short at #AAI2025! Today's our final day -- come by our booth #811 and say hi! Don't forget to pick up our latest Immunology collection 📚 + souvenir 🏝️

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS go.bsky.app/QSEPDoj

In new study, Simchoni et al. from Anthony Shum's lab (rupress.org/jem/article/...) compared five families and multiple generations to find a gene variant that prevents COPA Syndrome and opens the door to a new gene therapy for the condition. More from UCSF News: www.ucsf.edu/news/2025/02...

#RareDiseaseDay2025 @jem.org where we remain committed to publishing studies that identify inborn errors of immunity, elucidate underlying mechanisms and propose potential treatments for rare diseases. Some recent examples: doi.org/10.1084/jem.20240827 doi.org/10.1084/jem.20240843

KLF2 expression in IgG plasma cells at their induction site regulates the migration program, say Wataru Ise, Takuya Koike, Tomohiro Kurosaki @osaka_univ_e and colleagues: buff.ly/41bbKEF

Tomorrow is #RareDiseaseDay. An exciting discovery today for COPA syndrome, a rare heritable autoimmune disease. Finding a protective allele that has the potential to lead to a cure rupress.org/jem/article/...

Tejedor Vaquero, Neuman et al. @gmagrilab.bsky.social demonstrate immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease. https://buff.ly/4jVJYV5 📘 In Host–Microbe Interactions 2025 👉 https://buff.ly/40XMv8r

Kellog, @reboldilab.bsky.social, Vanni et al. reveal that #microbiome-driven tuft cells’ hyperplasia in the colon helps defend against Clostridioides difficile infection. https://buff.ly/3CRIPNy 📘 In Host–Microbe Interactions 2025 👉 https://buff.ly/40XMv8r

Mike Lauer follows Lawrence Tabak out the door at NIH www.statnews.com/2025/02/13/n...

Suin Jo, Kenneth Murphy et al. @washumedicine.bsky.social utilize several genetic models to distinguish roles of cDC1 and cDC2 in presentation of different forms of antigens to CD4⁺ and CD8⁺ T cells in vivo. https://buff.ly/42LUFDr

1/ Spots are still open for the 2025 Henry Kunkel Society Meeting on Genes & Immunity! Join us in Belgrade from April 10-12, 2025. www.henrykunkelsociety.org/meetings/ #HKS2025 #Immunology 🧬🔬

NIH plans to slash support for indirect research costs, sending shockwaves through science Capping these payments would ‘just grind our scientific complex to a halt,’ one researcher said @statnews.com www.statnews.com/2025/02/07/n...

Insights from Cadena & Blumenthal: Bernaleau et al. @rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96. https://buff.ly/4gwjt5N

“It will be much easier to destroy the world’s greatest scientific ecosystem than it will be to try to rebuild it” Scientists are worried about the long-term effects of the Trump administration’s actions https://go.nature.com/3PUKeGc

We’re thrilled to announce our partnership with the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) to launch the Journal of Human Immunity (JHI) @jhumimmunity.org (https://buff.ly/3PAEMrK)! Groundbreaking, #OpenAccess research on #HumanImmunity 👉 https://buff.ly/4ajqm8W

Our January Issue is here ✨ https://buff.ly/3W45Raw The image shows CD206+ #macrophage population marked by Venus expression (yellow) in B78chOVA tumor slices with transferred OT-I T cells marked by CD2dsRed (red). From Arja Ray, @maxkrummel.bsky.social et al. (https://buff.ly/3DHWwPl)

Our annual "Best of JEM" series highlights some of the most exciting studies from the last 12 months. We present you with research in basic #immunology, #immunotherapy and tumor immunology, inborn errors of immunity, #neurodegeneration, & #inflammation: https://buff.ly/4iwWcCJ

Breaking news: A 2020 paper that sparked widespread enthusiasm for hydroxychloroquine as a #COVID19 treatment has been retracted, following campaigning by scientists who alleged the research contained major scientific flaws and may have breached ethics regulations. scim.ag/4iR9bQ6