Gregor Bond
@gregorbond.bsky.social
📤 626
📥 580
📝 93
transplant nephrologist and psychotherapy student in Vienna (Austria)
Torque Teno Virus 🦠 ads to SOC to predict BK viraemia 🦠 can be 🦸♀️
#ttvguide
www.sciencedirect.com/science/arti...
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Predictive Value of TTV Viral Load for BKPyV DNAemia Depends on BKPyV-Specific Humoral Immunity in KTRs
Neutralizing antibodies (NAbs) have been proposed as biomarkers for stratifying BKPyV replication risk, while TTV viral load is recognized as a global…
https://www.sciencedirect.com/science/article/abs/pii/S1600613525030710
6 days ago
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thanks 🙏 BTS for the invitation! what a warm welcome to london 🇬🇧 I guess DSA, GEP, ddcfDNA and TTV will nicely come together as comprehensive immune monitoring post SOT
bts.org.uk/bts-autumn-s...
#TTVguide
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BTS Autumn Symposium - British Transplantation Society
The Fundamentals of Transplantation: A Joint Educational Event by The Herrick Society of Trainees in Transplant Surgery & The British Transplant Physician Trainees
https://bts.org.uk/bts-autumn-symposia/
12 days ago
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Immune Monitoring Goes Viral 🦠 Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation ⏩️ new review in TI 🔥
doi.org/10.3389/ti.2...
#ttvguide
12 days ago
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the cure for kidney week FOMO 😀
www.nephjc.com/news/kidneyw...
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Kidney Week in Houston: Day 1 — NephJC
in this edition: Atacicept in IgAN; Albuminuria as a surrogate outcome, Renal Remission and additional CONFIDENCE analysis
http://www.nephjc.com/news/kidneywk25-day1
14 days ago
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
18 days ago
The second sibeprenlimab paper in
@nejm.org
(At least we gave it an oral at
#KidneyWk
unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
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Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM
The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody, selectively binds to and...
https://www.nejm.org/doi/full/10.1056/NEJMoa2512133?query=RP&ssotoken=U2FsdGVkX18HwtSgXglJ1gbcCroISBKK7yPln43pSCZV8yPfQWUatNAzAHDZBaHCcgLB1ey0WaqsHwg9PzlzebfiBSX0qqNhK5vqLkva1kwLqzfHXq6r3A1Q2ZJqPOKnmHuZ7VTxPnkrt%2FDjX5BImxr3NHKvBalst0pzallnX5zWjaTtwNLPxgJ7wITboUre4GGzki3ZPnqTE%2BULAIOe5mWs5ItpHCKC8AWsoKuDhtE%3D&cid=NEJM%20Recently%20Published,%20November%208,%202025%20DM2425300_NEJM_Non_Subscriber&bid=-1078256474
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
18 days ago
And another ns-MRA Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
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Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinica...
In participants with chronic kidney disease at increased risk of disease progression, a fixed dose combination of balcinrenone and dapagliflozin was superior to dapagliflozin alone in reducing albumin...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02014-8/abstract
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reposted by
Gregor Bond
NEJM.org
20 days ago
ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria.
nej.md/3JEq8QL
@asnkidney.bsky.social
|
#KidneyWk
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
20 days ago
Eli Lilly continuing to hit it out the park Selective amylin agonist as an alternative to GLP1RAs?
#eloralintide
www.thelancet.com/journals/lan...
in
@thelancet.com
(Yeah I know it’s
#KidneyWk
but what do we do till Houston wakes up!) cc
@rnflex.bsky.social
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
19 days ago
Another simultaneous publication from the afternoon session Albuminuria as an acceptable surrogate outcome (per our discussion earlier today)
www.nature.com/articles/s41...
in
@naturemedicine.bsky.social
@nature.com
sadly paywalled
#KidneyWk
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A meta-analysis of albuminuria as a surrogate endpoint for kidney failure - Nature Medicine
In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidne...
https://www.nature.com/articles/s41591-025-04057-z
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
19 days ago
a conservative dialysis strategy in possibly recovering AKI helps people recover faster!
jamanetwork.com/journals/jam...
in
@jama.com
from
#KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
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A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury
This trial examines whether a conservative dialysis strategy can improve recovery of kidney function for patients with acute kidney injury who require dialysis.
https://jamanetwork.com/journals/jama/fullarticle/2841171
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
19 days ago
low dose Tac + Everolimus is not superior to Tac + MMF in older transplant recipients in
@asnpublications.bsky.social
another LBCT from
#KidneyWk
published
journals.lww.com/jasn/fulltex...
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https://journals.lww.com/jasn/fulltext/9900/immunosuppression_in_older_kidney_transplant.821.aspx
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jamesstein18.substack.com/p/my-hot-tak...
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My Hot Take on PISCES, the New Fish Oil in Hemodialysis Study
I love when a new study challenges what we think we know.
https://jamesstein18.substack.com/p/my-hot-take-on-pisces-the-new-fish
14 days ago
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😲 too good to be true? nothing except tx reduces death on hd and now…. something safe, cheep and with more effect than tx (and more effect than in non hd) waiting for the
@freelyfiltered.bsky.social
podcast covering this paper
www.nejm.org/doi/full/10....
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Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis | NEJM
Cardiovascular disease is the leading cause of death in patients receiving hemodialysis, yet effective preventive therapies remain limited. Supplementation with n−3 polyunsaturated fatty acids, esp...
https://www.nejm.org/doi/full/10.1056/NEJMoa2513032
14 days ago
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
22 days ago
Natural history of RRT from the ERA registry The visual abstract in this case tells a lot
academic.oup.com/ndt/advance-...
@ndt-era.bsky.social
#NephSky
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
about 1 month ago
Should we be screening every young child’s urine (as is done in some countries!)
@rheaultm.bsky.social
and Oliver Gross make the case in
@kireports.bsky.social
www.kireports.org/article/S246...
Main issue: we have therapeutic options!
#NephSky
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Urine screening to early diagnose young individuals with CKD: a call for action
Alport syndrome is an inherited disorder of basement membranes leading to progressive chronic kidney disease, hearing loss, and ocular abnormalities in many affected patients. When the authors started...
https://www.kireports.org/article/S2468-0249(25)00658-8/fulltext?rss=yes
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can viruses 🦠 be superheroes 🦸♂️ ? PhD student Felix Herkner just published the statistical analysis plan of the TTVguideIT trial 💪👏 Torque Teno virus guided immunosuppression
#TTVguide
data cleaning until Q1/26 analysis Q2/26
trialsjournal.biomedcentral.com/articles/10....
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Statistical analysis plan for TTVguideIT—a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immuno...
Background Non-interventional studies indicate an association between Torque Teno Virus (TTV) load in peripheral blood and immunosuppression related outcomes in kidney transplant recipients. This make...
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-025-09119-8
about 1 month ago
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
about 1 month ago
As expected, Iptacopan phase 3 in IgA nephropathy slows GFR decline APPLAUSE-IgA Adding another new medication we won’t be able to access or afford to our IgA armamentarium
#NephSky
www.novartis.com/news/media-r...
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Novartis Fabhalta® (iptacopan) meets Phase III primary endpoint, slows kidney function decline in patients with IgA nephropathy (IgAN)
https://www.novartis.com/news/media-releases/novartis-fabhalta-iptacopan-meets-phase-iii-primary-endpoint-slows-kidney-function-decline-patients-iga-nephropathy-igan
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
about 1 month ago
Big win for telitacicept in SLE (not lupus nephritis, yet)
www.nejm.org/doi/full/10....
BAFF + APRIL FTW
#nephSky
#Lupus
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A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus | NEJM
Telitacicept, a new dual inhibitor of the cytokines B-lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligand), showed efficacy in adults with active systemic lupus erythematosus (S...
https://www.nejm.org/doi/full/10.1056/NEJMoa2414719
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viruses 🦠 can be superheroes 🦸♀️ Felix Herkner present the statistical analysis plan of the TTVguideIT trial at the Austrian Transplant Congress Torque Teni Virus guided immunosuppression
#TTVguide
about 1 month ago
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happy to speak about TT virus 🦠 @Italien 🇮🇹 micro biology congress TTV based immune monotoring
#TTVguide
2 months ago
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mhm that makes me curiouse to have a look at the calculations of the DSMB that led to the termination of the trial; must have been a tought decision
add a skeleton here at some point
3 months ago
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well written; as a kidney doc I would just not agree that protein is bad for your kidneys
add a skeleton here at some point
3 months ago
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3 months ago
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>7.000 kidney transplant recipients on SGLT2 inhibitors & GLP-1RAs ▶️ better survival, cardiovascular & kidney outcomes, weight loss, lower HbA1c no safety risks
tinyurl.com/4p6fdybn
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SGLT2 Inhibitors and GLP-1 Receptor Agonists in Kidney... : Transplantation
ovascular and kidney benefits in non-KT recipients, but evidence in KT recipients remains limited. This systematic review and meta-analysis provide updated evidence on the efficacy and safety of SGLT2...
https://tinyurl.com/4p6fdybn
3 months ago
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reposted by
Gregor Bond
Joel Topf
4 months ago
I use a cool programmable calculator called Soulver that works on and syncs across my iPhone, iPad, and Mac. I just created a formula to calculate the sodium after any combination of IV fluids and urine output based on Edelman.
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Gregor Bond
TTVguideTX
4 months ago
Last week, our team around
@gregorbond.bsky.social
from
@meduniwien.ac.at
took part in the "Kinderuni Wien" - Vienna’s Children’s University - to bring science to life for curious kids aged 7 to 12, where the kids learnt that some viruses like TTV can also be superheroes.
#TTVguide
add a skeleton here at some point
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I had great fun at kids university
@meduniwien.ac.at
today 😁 viruses 🦠 can be superheroes 🦸♀️ 🙏
@sebastiankaps.bsky.social
and
@fredhaupenthal.bsky.social
for your support
#ttvguide
4 months ago
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reposted by
Gregor Bond
TTVguideTX
5 months ago
Our team around
@gregorbond.bsky.social
recently participated at
#ESOT2025
- here's our most important learnings: 🔸 More & more groups worldwide pick up the idea of TTV-guided immunosuppression. 🔸 First data on the association between TTV load & the development of malignomes is available.
#ttvguide
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the highly prevalent and apathogenic TorqueTeno virus 🦠 is associated with immunosuppression 💊 Carsten Herz presents first data on the predicive value of malignancy post kidney transplant
#TTVguide
5 months ago
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#ESOTCongress
London 🇬🇧 Action at the eposters a multicenter observational study to validate the value of proteinuria for assessment of kidney graft quality
5 months ago
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#ESOTCongress
2025 London 🇬🇧 action at the eposters Torque Teno virus 🦠 for the prediction of Infection post kidney TX first long term data
#TTVguide
5 months ago
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#ESOTCongress
London 🇬🇧 presidents dinner ☺️
5 months ago
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freddi at
#ESOTcongress
🇬🇧 depression is a major factor for reduced HRQOL post kidney TX
@fredhaupenthal.bsky.social
5 months ago
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happy 😊 meeting you @
#ESOTcongress
this Monday 1.7. in London 🇬🇧 talks 🗣️ on Torque Teno virus 🦠 guided immunosuppression 💊 09:30 and 11:00 room S1 13:15 room S5, 16:15 room S4
#ttvguide
5 months ago
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meet me at
#ESOTcongress
in London 🇬🇧 🗓️ July 1, 13:00-14:00, ROOM s5 to discuss Torque Teno virus 🦠 based immunologic monotoring viruses 🦠 can be superheroes 🦸
#ESOT2025
#TTVguide
#ESOT
5 months ago
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this will be fun!
#TTVguide
add a skeleton here at some point
6 months ago
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congrets to Katharina Mayer receiving the young investigator award @
#ERA25
👏 how do TX baseline and fup data influence TT virus 🦠 load?
#TTVguide
6 months ago
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torque teno virus 🦠 load predicts malignoma post kidney TX 💪 👏 carsten herz at
#era25
viruses 🦠 can be 🦸 superheros TTVbased immune monitoring
#TTVguide
6 months ago
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Sebastian Kapps presents first data on Torque Teno virus 🦠 in long-term kidney TX patients at
#ERA25
#TTVguide
6 months ago
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#TTVguide
💪
add a skeleton here at some point
6 months ago
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reposted by
Gregor Bond
Swapnil Hiremath 🍁🇨🇦
6 months ago
The first
#ERA25
simultaneous pub CONFIDENCE trial of empagliflozin + finerenone in N = 579 Greater reduction in ACR and BP Note the impressive GFR dip
www.nejm.org/doi/full/10....
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full engangement on our „year 4“ TTVguideTX project meeting 💪 viruses 🦠 can be superheros 🦸♀️
#TTVguide
6 months ago
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reposted by
Gregor Bond
Joel Topf
6 months ago
This was a fun article to work on. Hope you enjoy it. Things We Do for No Reason™: Avoiding IV iodinated contrast material in patients with acute kidney injury or chronic kidney disease Journal of Hospital Medicine
shmpublications.onlinelibrary.wiley.com/doi/10.1002/...
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Things We Do for No Reason™: Avoiding intravenous iodinated contrast material in patients with acute kidney injury or chronic kidney disease
Click on the article title to read more.
https://shmpublications.onlinelibrary.wiley.com/doi/10.1002/jhm.70063
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we did it 👏🍾🎉🕺💃☺️ today was last visit of the last patient of the TTVguideIT study 260 KTX recipients randomiced to torque teno virus 🦠 guided immunosuppression vs SOC and followed for one year thanks to all 13 recruiting centers across europe
#ttvguide
6 months ago
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@fredhaupenthal.bsky.social
add a skeleton here at some point
6 months ago
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reposted by
Gregor Bond
NDT
7 months ago
Self-reported non-adherence to immunosuppressive medication detected by the BAASIS predicts allograft rejections in kidney transplant recipients
doi.org/10.1093/ndt/...
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Sebastian Kapps taking science 🧬 to the public 👨🏽🦱👩🏾👨🏼🦲👵🏼 can we use a virus 🦠 to quantify the immune system?
#ttvguide
6 months ago
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the BAASIS - a simple self assessement tool - predicts clinically relevant non-adherence in kidney TX patients
academic.oup.com/ndt/advance-...
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Self-reported Non-adherence to Immunosuppressive Medication Detected by the BAASIS Predicts Allograft Rejections in Kidney Transplant Recipients
AbstractBackground. After kidney transplantation adherence to immunosuppressive medication is crucial for graft survival and its assessment requires valid
https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt/gfaf078/8121407
7 months ago
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reposted by
Gregor Bond
TTVguideTX
7 months ago
Watch
@fredhaupenthal.bsky.social
-
#TTVguide
investigator from
@meduniwien.ac.at
presenting first data from the AdTorque trial: self-reported non-adherence by the BAASIS predicts graft rejection
oup.cloud.panopto.eu/Panopto/Page...
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Self-reported Non-adherence to Immunosuppressive Medication Detected by the BAASIS Predicts Allograft Rejections in Kidney Transplant Recipients
Presented by Gregor Bond Article DOI:
https://oup.cloud.panopto.eu/Panopto/Pages/Viewer.aspx?id=edf1261a-7b67-4aeb-9d4d-b2bc011ef167
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