clinical trial simulations to optimise analysis strategies for multiple endpoints highlight the trade-off between statistical efficiency and interpretability #ttvguide www.nature.com/articles/s41...

Remember the TOPCAT story of what happened in Russia and Georgia? This is worse: www.science.org/content/blog... And in South Florida. From @dereklowe.bsky.social

Should we be treating inpatient hypertension? Interesting case with two discussants (Michael Rothberg vs Tara Chang) www.nejm.org/doi/full/10.... I have to confess despite being a nihilist for treating inpatient BP I am tempted to do something in this setting.

no screening in Austria 🇦🇹 😥

Torque Teno Virus 🦠 ads to SOC to predict BK viraemia 🦠 can be 🦸‍♀️ #ttvguide www.sciencedirect.com/science/arti...

thanks 🙏 BTS for the invitation! what a warm welcome to london 🇬🇧 I guess DSA, GEP, ddcfDNA and TTV will nicely come together as comprehensive immune monitoring post SOT bts.org.uk/bts-autumn-s... #TTVguide

Immune Monitoring Goes Viral 🦠 Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation ⏩️ new review in TI 🔥 doi.org/10.3389/ti.2... #ttvguide

the cure for kidney week FOMO 😀 www.nephjc.com/news/kidneyw...

The second sibeprenlimab paper in @nejm.org (At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!) www.nejm.org/doi/full/10....

And another ns-MRA Balcinrenone added to Dapa in proteinuric CKD #KidneyWK @thelancet.com www.thelancet.com/journals/lan...

ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL @asnkidney.bsky.social | #KidneyWk

Eli Lilly continuing to hit it out the park Selective amylin agonist as an alternative to GLP1RAs? #eloralintide www.thelancet.com/journals/lan... in @thelancet.com (Yeah I know it’s #KidneyWk but what do we do till Houston wakes up!) cc @rnflex.bsky.social

Another simultaneous publication from the afternoon session Albuminuria as an acceptable surrogate outcome (per our discussion earlier today) www.nature.com/articles/s41... in @naturemedicine.bsky.social @nature.com sadly paywalled #KidneyWk

a conservative dialysis strategy in possibly recovering AKI helps people recover faster! jamanetwork.com/journals/jam... in @jama.com from #KidneyWk Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?

low dose Tac + Everolimus is not superior to Tac + MMF in older transplant recipients in @asnpublications.bsky.social another LBCT from #KidneyWk published journals.lww.com/jasn/fulltex...

😲 too good to be true? nothing except tx reduces death on hd and now…. something safe, cheep and with more effect than tx (and more effect than in non hd) waiting for the @freelyfiltered.bsky.social podcast covering this paper www.nejm.org/doi/full/10....

Natural history of RRT from the ERA registry The visual abstract in this case tells a lot academic.oup.com/ndt/advance-... @ndt-era.bsky.social #NephSky

Should we be screening every young child’s urine (as is done in some countries!) @rheaultm.bsky.social and Oliver Gross make the case in @kireports.bsky.social www.kireports.org/article/S246... Main issue: we have therapeutic options! #NephSky

can viruses 🦠 be superheroes 🦸‍♂️ ? PhD student Felix Herkner just published the statistical analysis plan of the TTVguideIT trial 💪👏 Torque Teno virus guided immunosuppression #TTVguide data cleaning until Q1/26 analysis Q2/26 trialsjournal.biomedcentral.com/articles/10....

As expected, Iptacopan phase 3 in IgA nephropathy slows GFR decline APPLAUSE-IgA Adding another new medication we won’t be able to access or afford to our IgA armamentarium #NephSky www.novartis.com/news/media-r...

Big win for telitacicept in SLE (not lupus nephritis, yet) www.nejm.org/doi/full/10.... BAFF + APRIL FTW #nephSky #Lupus

viruses 🦠 can be superheroes 🦸‍♀️ Felix Herkner present the statistical analysis plan of the TTVguideIT trial at the Austrian Transplant Congress Torque Teni Virus guided immunosuppression #TTVguide

happy to speak about TT virus 🦠 @Italien 🇮🇹 micro biology congress TTV based immune monotoring #TTVguide

mhm that makes me curiouse to have a look at the calculations of the DSMB that led to the termination of the trial; must have been a tought decision

well written; as a kidney doc I would just not agree that protein is bad for your kidneys

>7.000 kidney transplant recipients on SGLT2 inhibitors & GLP-1RAs ▶️ better survival, cardiovascular & kidney outcomes, weight loss, lower HbA1c no safety risks tinyurl.com/4p6fdybn

I use a cool programmable calculator called Soulver that works on and syncs across my iPhone, iPad, and Mac. I just created a formula to calculate the sodium after any combination of IV fluids and urine output based on Edelman.

Last week, our team around @gregorbond.bsky.social from @meduniwien.ac.at took part in the "Kinderuni Wien" - Vienna’s Children’s University - to bring science to life for curious kids aged 7 to 12, where the kids learnt that some viruses like TTV can also be superheroes. #TTVguide

I had great fun at kids university @meduniwien.ac.at today 😁 viruses 🦠 can be superheroes 🦸‍♀️ 🙏 @sebastiankaps.bsky.social and @fredhaupenthal.bsky.social for your support #ttvguide

Our team around @gregorbond.bsky.social recently participated at #ESOT2025 - here's our most important learnings: 🔸 More & more groups worldwide pick up the idea of TTV-guided immunosuppression. 🔸 First data on the association between TTV load & the development of malignomes is available. #ttvguide

the highly prevalent and apathogenic TorqueTeno virus 🦠 is associated with immunosuppression 💊 Carsten Herz presents first data on the predicive value of malignancy post kidney transplant #TTVguide

#ESOTCongress London 🇬🇧 Action at the eposters a multicenter observational study to validate the value of proteinuria for assessment of kidney graft quality

#ESOTCongress 2025 London 🇬🇧 action at the eposters Torque Teno virus 🦠 for the prediction of Infection post kidney TX first long term data #TTVguide

#ESOTCongress London 🇬🇧 presidents dinner ☺️

freddi at #ESOTcongress 🇬🇧 depression is a major factor for reduced HRQOL post kidney TX @fredhaupenthal.bsky.social

happy 😊 meeting you @ #ESOTcongress this Monday 1.7. in London 🇬🇧 talks 🗣️ on Torque Teno virus 🦠 guided immunosuppression 💊 09:30 and 11:00 room S1 13:15 room S5, 16:15 room S4 #ttvguide

meet me at #ESOTcongress in London 🇬🇧 🗓️ July 1, 13:00-14:00, ROOM s5 to discuss Torque Teno virus 🦠 based immunologic monotoring viruses 🦠 can be superheroes 🦸 #ESOT2025 #TTVguide #ESOT

this will be fun! #TTVguide

congrets to Katharina Mayer receiving the young investigator award @ #ERA25 👏 how do TX baseline and fup data influence TT virus 🦠 load? #TTVguide

torque teno virus 🦠 load predicts malignoma post kidney TX 💪 👏 carsten herz at #era25 viruses 🦠 can be 🦸 superheros TTVbased immune monitoring #TTVguide

Sebastian Kapps presents first data on Torque Teno virus 🦠 in long-term kidney TX patients at #ERA25 #TTVguide

#TTVguide 💪

The first #ERA25 simultaneous pub CONFIDENCE trial of empagliflozin + finerenone in N = 579 Greater reduction in ACR and BP Note the impressive GFR dip www.nejm.org/doi/full/10....

full engangement on our „year 4“ TTVguideTX project meeting 💪 viruses 🦠 can be superheros 🦸‍♀️ #TTVguide

This was a fun article to work on. Hope you enjoy it. Things We Do for No Reason™: Avoiding IV iodinated contrast material in patients with acute kidney injury or chronic kidney disease Journal of Hospital Medicine shmpublications.onlinelibrary.wiley.com/doi/10.1002/...

we did it 👏🍾🎉🕺💃☺️ today was last visit of the last patient of the TTVguideIT study 260 KTX recipients randomiced to torque teno virus 🦠 guided immunosuppression vs SOC and followed for one year thanks to all 13 recruiting centers across europe #ttvguide