a new mRNA therapy apparently can cut the rate of Huntington's disease progression by ~75%. yet more miracle shit www.bbc.com/news/article...

The Plasma Oxylipin Signature Provides a Deep Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria #GLA #DGLA #MECFS #LongCovid www.mdpi.com/1422-0067/23...

12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in Platelets #DGLA #MECFS #LongCovid www.ahajournals.org/doi/full/10....

OmniSeq INSIGHT #MECFS #LongCovid oncology.labcorp.com/cancer-care-...

STAT3 Contributes to Intracranial Aneurysm Formation and Rupture by Modulating Inflammatory Response #MMP2 #MMP9 #MECFS #LongCovid pmc.ncbi.nlm.nih.gov/articles/PMC...

SORD Deficiency Disorder #MECFS #LongCovid cmtrf.org/what-is-cmt-...

STAT3 Regulates Collagen-Induced Platelet Aggregation Independent of its Transcription Factor Activity #MECFS #LongCovid pmc.ncbi.nlm.nih.gov/articles/PMC...

Serum Calprotectin is Indicating Clinical and Ultrasonographic Disease Activity in Rheumatoid Arthritis, even with Normal C-Reactive Protein Levels #MECFS #LongCovid pmc.ncbi.nlm.nih.gov/articles/PMC...

Function of Mitochondrial Stat3 in Cellular Respiration #IFNα #IFNβ #MECFS #LongCovid www.science.org/cms/asset/53...

Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology #hEDS #MECFS #LongCovid academic.oup.com/immunohorizo...

One in Ten Childhood Blood Cancers May Stem From Medical Scans Nearly 4 million children. Twenty-one years of follow-up data. And a finding that might make parents think twice about that "routine" CT scan. A sweeping new study led by UC San Francisco and UC Davis researchers has drawn a direct…

Discovery of Small Molecules for the Reversal of T Cell Exhaustion #MECFS #LongCovid www.cell.com/cell-reports...

@nicktsergas.ca In BC, access to antivirals appears to be a lot more restrictive: eg. Access and coverage of antiretroviral drugs through Canada’s provincial and territorial drug programs hivclinic.ca/wp-content/u...

Cerebellar Ataxia and CSF Folate Deficiency #MECFS #LongCovid pediatricneurologybriefs.com/articles/10....

Twenty years of dysuria in a patient with Addison’s disease: a case report #MECFS #LongCovid pdfs.semanticscholar.org/e2a1/8c282ff...

Inflammation in surrounding tissue can activate dormant cancer cells, prompting them to multiply and potentially form new tumors, highlighting a key factor in cancer recurrence and metastasis. doi.org/g92kc2

‘Transcriptotype’ explains phenotypic variability of inborn errors of immunity #MECFS #LongCovid www.nature.com/articles/s41... "In addition, autosomal random monoallelic expression (aRMAE) can cause somatic commitment to stable monoallelic gene expression."

The 2024 rankings of bacterial threats

🫴 Genomic analyses of hair from Ludwig van Beethoven: Current Biology www.cell.com/current-biol...

“#LongCovid pts showed significantly more dilated capillaries, microhaemorrhages, abnormal shapes than healthy matched control subjects and of note, lower mean capillary number per linear millimetre.” Study: rmdopen.bmj.com/content/11/2...

Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner #GLP1 #UDCA www.sciencedirect.com/science/arti...

STAT Family Proteins and Interferon Interactions (Claude AI summary) #MECFS #LongCovid

Russia is developing an automated control system to support China's amphibious operations against Taiwan, leaked documents from the BlackMoon hacker group reveal. Russia's Rosoboronexport has signed a €4.284 million contract with China's CETC International Co Ltd. (Vanguard Intel)

I got to try this too and more of my my capillaries were enlarged (85%!) than anyone else’s that evening

Just co-authored a new Nature study led by James DeGregori showing that SARS-CoV-2 can awaken dormant cancer cells, triggering aggressive metastasis via IL-6-driven inflammation. COVID-19 may spark a wave of cancer relapses. Vaccines & IL-6 blockers could help. 🔗 www.nature.com/articles/s41...

The first report on detecting #SARSCoV2 inside bacteria of the human gut microbiome: A case series on asymptomatic family members and a child with #COVID19 #MECFS #LongCovid pmc.ncbi.nlm.nih.gov/articles/PMC...

A recent study by Jerez-Martínez et al. shows that both 10-RM & 20-RM resistance training to failure lead to similar improvements in oxidative capacity, hypertrophy, and strength after just 6 weeks.

I'm pleased to share a preprint today, paper 2/3 of a trilogy (you'll have to wait for the Return of the Jedi). In 2021-22, lots of countries saw unprecedented transmission of enteric adenovirus F41 in children. There were lots of hypotheses about what caused this. www.biorxiv.org/content/10.1...

ZNFX1: a multifunctional modulator of the innate immune response #MECFS #LongCovid pmc.ncbi.nlm.nih.gov/articles/PMC...

The real goal of internet age verification is to de-anonymize the internet so that your data - and your opinions - can more easily be collected and sold to whatever corporations (or governments) are interested in them. www.donotpanic.news/p/were-losin...

Delighted to share our latest review in Nature Reviews Neuroscience! We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies. www.nature.com/articles/s41...

Initial findings from the @decodemestudy.bsky.social genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome #MECFS www.research.ed.ac.uk/en/publicati... eg. - FBXL4 (MITOCHONDRIAL DNA DEPLETION SYNDROME 13) - ZNFX1 (IMMUNODEFICIENCY 91 AND HYPERINFLAMMATION)

From @danielmissailidis.bsky.social on X: "One of the genes is FBXL4, critical for mitophagy. This is the process by which our mitochondria are recycled, whether due to damage or other reasons. Mitophagy’s been slept on in ME/CFS research and could explain a lot of what’s going wrong..." #decodeME

Gotcha! Whole-genome sequencing discovers seven unidentified bacteria of clinical relevance #MECFS #LongCovid www.biotechniques.com/computationa...

(1/2) Key genetic differences found in people with ME/CFS > Swipe to find out more. These findings reflect the lived experience of thousands of #pwME. Thanks to all our participants & supporters who made this possible! Read a summary of our results: shorturl.at/pgsjk

New @nature.com The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses nature.com/articles/s41...

MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation #MECFS #LongCovid www.sciencedirect.com/science/arti...

Bacteria-based cancer therapy achieves tumor eradication without immune cells flip.it/XJYSqh

The initial DNA results from DecodeME are coming this week! We will release them on our website on Wednesday 6th August at 7pm (approx). We're letting you know the timing in advance so you can pace beforehand. Thank you to our participants & supporters.

Now online in Cancer Discovery @aacrjournals.bsky.social: Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling - by Hsi-wen Yeh, Nicole Del Gaudio, Kivanç Birsoy, and colleagues doi.org/10.1158/2159... @rockefelleruniv.bsky.social

Preliminary Clinical Trial Results Show ‘Dramatic and Rapid’ Regression of Glioblastoma after Next Generation CAR-T Therapy www.massgeneral.org/news/press-r...

Less active versions of the NOD2 gene, when combined with immunotherapy or radiotherapy, may enhance the immune system’s ability to target and eliminate cancer cells. doi.org/g9v4ch

#STAT1-GOF is characterized by infections & #autoimmunity. Buddingh, Schuetz et al report overall survival after allogeneic #HSCT in an international cohort of 36 patients is 72.2%. Pre-treatment w/ JAK inhibitors is associated w/ better event-free survival rupress.org/jhi/article/...

Case-based evidence links increased #SARSCoV2 diversity to impaired IFN-I response in severe #COVID19. New report from David Bussy, Sophie Trouillet-Assant and colleagues (Université Claude Bernard, @inserm.fr @cnrs.fr): rupress.org/jhi/article/... #Infections #AutoAntibodies

Mitochondria do more than make energy, they help fight infections. New research shows they detect bacterial lactate & trigger neutrophils to release NETs that trap pathogens. More @ConversationUS : theconversation.com/mitochondria...

Motherfucking wind farms…

A fish started a wildfire. www.cbc.ca/news/canada/...

Effect of Hi-OxSR for the Treatment of Post COVID Condition (RECLAIM-HiOxSR) #MECFS #LongCovid clinicaltrials.gov/study/NCT069...

Scientists used a mRNA-based vaccine to reliably trigger antibodies that block HIV infection in people and monkeys www.statnews.com/2025/07/30/m...

And you thought #metformin lowered glucose via the liver? Here loss-of-function and gain-of-function studies suggest that VMH Rap1 is indispensable for the antidiabetic effects of metformin in mice #diabetes www.science.org/doi/10.1126/...