Our opinion article is out now on: Disentangling the response to lysosomal damage journals.biologists.com/jcs/article-... It discusses the concept of lysosome regeneration and the tools and reporters for diverse branches of the pathway. Great to work with coauthors Akiko and Shuhei.

📯 Our paper “VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair” out now in Nature Communications rdcu.be/frKmN

Feeling truly honored to receive the Otto Hahn Medal from the @maxplanck.de ! Huge thanks to my mentor @andrea-musacchio.bsky.social for his continuous guidance and support over the years. It has been a pleasure working with you.

Fantastic work by Aakriti Jain @aakritijain.bsky.social in team with Claire Goul and the Laboratory for Genome Research reveals the LASER pathway and its core component TFG as critical for rapid ESCRT-dependent lysosomal membrane repair, pointing to a deep connection with neurodegeneration!

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

Excellent talk by our @unidue-zmb.bsky.social colleague Pinki Galhot from @hemmo-lab.bsky.social @imprs-lm.bsky.social 👏 #MK2026 @gbmev.bsky.social

VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now: Science Advances www.science.org/doi/10.1126/...

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

Excellent thesis defense by Pinki Gahlot concluding brillant work on a sensor module, SPG20-ITCH that detects lipid packing defects in the limiting membrane of permeabilized #lysosomes and initiates #lysophagy.

New Online! Lysosomal membrane homeostasis and its importance in physiology and disease

ATXN3-p97 facilitates #lysosomal restoration after damage by deubiquitinating LAMP2 and targeting it for degradation via microautophagy Hemmo Meyer and coworkers @hemmo-lab.bsky.social www.embopress.org/doi/full/10....

Thrilled to share our work on the role of Ataxin-3 in lysosome regeneration published in @embojournal.org . Here we show that Atxn3 targets K48-K63 branched ubiquitin chains on damaged lysosomes and mediates restoration of lysosomal function via microautophagy. www.embopress.org/doi/full/10....