Detecting the Activation of Endogenous Small GTPases via Fluorescent Signals Utilizing a Split mNeonGreen: Small GTPase ActIvitY ANalyzing (SAIYAN) System bio-protocol.org/en/bpdetail?...

Phosphorylation-coupled autoregulation of TANGO1 and Sec16A maintains functional ER exit sites www.nature.com/articles/s41...

Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional. Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals? www.nature.com/articles/s41...

Our paper is now out in Nature Communications! Phosphorylation-coupled autoregulation of TANGO1 and Sec16A maintains functional ER exit sites. rdcu.be/eRNLt TANGO1 and Sec16 need a Goldilocks level of phosphorylation — not too high, not too low.

Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:

New Online! Towards a unified framework for the function of endoplasmic reticulum exit sites

Our lab website has been updated!　 ksaitolab.com

Phosphorylation-Coupled Autoregulation Maintains Functional ER Exit Sites https://www.biorxiv.org/content/10.1101/2025.06.18.660491v1

This is my first post. We are very happy to share the following preprint! Our work introduces a novel concept that the functional state of the ERES is maintained through the autoregulated phosphorylation–dephosphorylation cycle of key scaffold proteins. www.biorxiv.org/content/10.1...