Excited to share our latest paper in which we discuss merging theory-and data- driven computational psychiatry in a large transdiagnostic cohort study (N=2400) www.biologicalpsychiatrycnni.org/article/S245... Christopher Pittenger, Godfrey Pearlson @annierhcheng.bsky.social @sobp-org.bsky.social

I wrote an perspectives piece relevant to the structural atlasing endeavors. Structural atlases are not the end of the story. This perspective calls for models that take into account the flexible functional organization within this fixed architecture. www.frontiersin.org/journals/neu...

Looking for a postdoc in #computationalpsychiatry? Apply here to join an interdisciplinary team and work with a large longitudinal transdiagnostic dataset postdocs.yale.edu/posts/2026-0... @RobbRutledge @xiaosigu @DrChrisPitt @PearlsonGodfrey @ACNPorg @YaleMed

This paper had a pretty shocking headline result (40% of voxels!), so I dug into it, and I think it is wrong. Essentially: they compare two noisy measures and find that about 40% of voxels have different sign between the two. I think this is just noise!

It’s officially out! Check out the manuscript for more on the effect size web app, led by the truly indefatigable @halleeshearer.bsky.social and featuring so many contributions from this team, esp MINDS Lab via @dscheinost.bsky.social

Take a look at our paper! Led by @francimandi.bsky.social in the Lake lab: "Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice" !!!! www.biorxiv.org/content/10.1...

Talking about spooky stuff…try to do awake mouse fMRI. Oh, you want it spookier? Try to add simultaneous Ca2+ imaging. Now, do it all again, longitudinally…. So proud to finally have this out!!! 🐭 🧠 🧲 Go read…if you dare!! 👻 www.biorxiv.org/content/10.1...

MacArthur ‘Genius Grant’ Awarded To Inventor Of Eatin’ Shirt https://theonion.com/macarthur-genius-grant-awarded-to-inventor-of-eatin-shirt/

Really proud to share this w/ @francimandi.bsky.social from the Lake lab: we applied fingerprinting in a simultaneous wide-field fluorescence Ca2+ imaging and BOLD-fMRI dataset in mice! w/ @toddc.bsky.social @mallarchak.bsky.social @richardfbetzel.bsky.social et al. www.nature.com/articles/s42...

Launched in 2023, Imaging Neuroscience is now firmly established, with full indexing (PubMed, etc.) and 700 papers to date. We're very happy to announce that we are able to reduce the APC to $1400. Huge thanks to all authors, reviewers, editorial team+board, and MIT Press.

Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇

This feels like a spot of good news www.sciencedaily.com/releases/202...

Check out the latest from @daveocskys.bsky.social ! Cool work looking at functional connectivity dynamics and predictive-modeling of brain-behavior relationships!! 🔥 🔥 W/ @toddc.bsky.social @francimandi.bsky.social

What happens in the brain when we breathe? 🧠 🔄 🫁 🧠 The functional state of the brain fluctuates across the respiratory cycle 🫁 Brain activity can be volitionally influenced by varying the rate, depth, and pattern of breathing Read more ➡️ doi.org/10.1016/j.bi... @uniofjyvaskyla.bsky.social

Recently had the last piece of work from my PhD published, only took 2.5 years or so. Check it out here! Thanks to @coreyhorien.bsky.social @francimandi.bsky.social @toddc.bsky.social

This New Yorker piece about the Irish Famine has several paragraphs I found literally jaw-dropping (positive). This is a book review!! Good god!!!

Unbelievable news. Pancreatic is one of the deadliest cancers. New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care. www.nature.com/articles/s41...

The first measles death in the US in a decade -- the tragic, preventable death of a child whose parents chose not to protect them with vaccination -- should spark an immediate nation-wide campaign to ensure all children are protected against preventable diseases. Anything less is unconscionable.

THIS IS HUGE! A cancer vaccine developed by Yale University and DFCI shows MAJOR promise. Results of an early-phase trial reveal ALL patients with ADVANCED stage kidney cancer had successful anti-cancer immune responses AND have remained CANCER-FREE approximately THREE years after treatment. 🧪🧵⬇️

We've updated our mouse connectome-based ID paper using simultaneous Ca2+ imaging and fMRI connectivity data--check it out! www.biorxiv.org/content/10.1... Shoutout to all! @francimandi.bsky.social, @toddc.bsky.social, @mallarchak.bsky.social, @richardfbetzel.bsky.social, and many others! 1/2

Unclear if Jordan Peterson was entirely read up on Nigel Farage when the two appeared 'in conversation' at the Arc conference this morning...

Maybe I wasn’t clear about this. I wanted more egg and no plane crash, not many plane crash and no egg.

A BBC study just found that generative AI can't even generate news story synopses with any consistent accuracy, and here we are happily pretending it's a symmetrical replacement for education and experience

Newsletter: Generative AI is a marketing con perpetuated by Sam Altman and Dario Amodei through a mixture of lies and half-truths carried by a tech media that fails to ask the right questions. Outside of ChatGPT, generative AI companies barely get any traffic at all. www.wheresyoured.at/longcon/

BBC asked leading AI tools 100 basic questions, using its articles as sources. Significant issues with just over half of the answers. Clear factual errors in a fifth Where answers included quotes from BBC articles, more than 1 in 10 were altered, or didn’t exist www.bbc.co.uk/mediacentre/...

This, by @martinsandbu.ft.com is very good. If the EU can figure out a way through the next few years, there is a real chance it will have a long term advantage as only major power with a semi-functional governance system.

The whole "$1 NIH dollar generates $2.50 in output" sells science wildly short. Scientific discovery and technological development is the foundation on which our entire society is built -- and that includes all the businesses that operate within it. The throughlines are shorter than you think: 1/n

Come join Raredon Lab! We have a cool project running 🏃🏻‍♂️on post-pneumonectomy lung regeneration 🫁 and we are looking for a new post-doctoral recruit…lots of opportunity for creativity and experimentation! Tons of data viz too… 📈🤔🧐💫 and tissue microscopy…🔬 DM with questions!!

Thus far OpenAI & its peer scaling labs have sought to convince the public & policymakers that scaling is the best way to reach so-called AGI. This has always been more of an argument based in business than in science. 4/

This paper is an excellent reminder that the brain works across space and time and that we can appreciate both, even with fMRI data.

Take a look at some of our latest results, diving into task-fMRI data, autism, and predictive modelling: "What is the best brain state to predict autistic traits?" www.medrxiv.org/content/10.1... 1/2

"Bluesky moderation lists create echo chambers." A short thread about decentralized moderation on Bluesky and why it changes everything.* 🧵 *Based on nearly a thousand hours spent exploring the platform's code.

1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce". Prepare to get cheesy, I'm glad to share the Cacio e paper preprint: arxiv.org/abs/2501.00536

Medical breakthroughs through the ages, a 🧵 1923: Banting and Best develop insulin. Banting thought it was unethical for a doctor to patent a life-saving discovery. To maximize the availability of insulin, he and Best sold the patent to the University of Toronto for $1.

The best first sentence of a grant application I've read was (paraphrasing), "Tool X is widely used to do task Y; we will make it accessible to people living with condition Z (13% of the population) so that it is more equitable and more widely used". Let's unpack why, because there's a lesson. 🧵

Official postdoc ad is up! Please share or apply if you are interested in joining our group here at the Yale PET center and working on cutting-edge imaging for diabetes and obesity! postdocs.yale.edu/postdoctoral...

hey -- i'm hiring a postdoc! the ad will be up shortly, but looking for someone with network neuroscience experience (very broadly). the position isn't tied to any specific project/grant, so lots of flexibility in terms of what you'd actually *do*. hmu if you might be interested/want to learn more!

I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that have been floating around. It is important to understand how this agency actually functions and point criticism at the right problems. A short 🧵:

Beginning to understand why so many Americans are obsessed with trans issues and panicking about being replaced. They think there are 21x more trans people, 27x more muslims, 15x more jews, 5x more asians, 3x more black people, and 2x more immigrants than there actually are.

Scikit-learn is on bluesky 🧡💙

Latest work led by Xihan Zhang looking at the cell-type underpinnings of the human functional cortical connectome is out now in Nature Neuro! 🧠 www.nature.com/articles/s41...

fMRI network measures are affected by sampling error 🎲, physiological artifacts 💗, arousal 👀, and task state 🎞️. We argue that a major challenge in studies of 🧠 network dynamics is distinguishing between these sources of variability. A 🧵 …