In December's #EditorsChoice, Nayeli Reyes-Nava, @edwardmarcotte.bsky.social, @jbwallingford.bsky.social & co use #Xenopus model to study #Cilia motility disturbances in primary ciliary dyskinesia #PCD ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

Genetically engineered ESC-derived embryos reveal Vinculin-dependent force responses required for mammalian neural tube closure https://www.biorxiv.org/content/10.64898/2025.12.22.696028v1

The final manuscript detailing a great collaborative effort between Saikat Mukhopadhyay's group and ours, spearheaded by the amazing Sun-Hee Hwang is out now! We disambiguate the roles of activating and repressive arms of Hh signaling during cranial neural tube closure. doi.org/10.1242/dev....

The prickly consequences of Hedgehog de-repression on cranial neural tube closure This Research Highlight showcases work by Eric R. Brooks @tomorrowbot.bsky.social, Sun-Hee Hwang, Kevin A. White and Saikat Mukhopadhyay: journals.biologists.com/dev/article/...

Thanks to @devbiol.bsky.social for featuring our work! This was a great project, though one with many confusing turns at times, which only seems right for exploring something to do with such a re-iteratively used pathway as Wnt signaling

Cilia Alert! So excited to finally have this paper on the CPLANE complex out in @natcomms.nature.com! We show that RSG1 is a human ciliopathy protein and links CPLANE to the transition zone. 1/n www.nature.com/articles/s41...

A look at the developing human embryonic forebrain in 3D! Post-doc @stochastalive.bsky.social shares this week's image showing a dorsal view of the human embryonic forebrain at Carnegie Stage 16 (~6 weeks post conception). Major regions marked by FOXG1, WNT8B, PAX6, and SHH are displayed.

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data" A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making Applied to ventral neural tube development www.biorxiv.org/content/10.1...

#ApicalConstriction and #DevBio afficionados - we've got two new pre-prints you may be interested in, below:

Congrats on the big year, Ben!

WOW! Been a crazy busy year but we've gotten a lot of stuff across the finish line. All the credit to my team here at U of L and our collabs at IU SOM, Oxford, CU Anschutz and UC Merced! Gonna update y'all with this Bluetorial!

The "Biological Differentiation Across the Scales" virtual seminar series kicked off on April 28 with an insightful, engaging talk by @ecbrooks96.bsky.social. Missed it live? Watch the recording: www.isdifferentiation.org/Journal/Page... @rogerslabucd.bsky.social @uribelab.bsky.social #devbio

We are pleased to share the version of record of our study on the complex role of Wnt signaling in control of cell behavior during cranial neural tube closure. This work was spearheaded by the fantastic Amber Bogart and is out now in @devbiol.bsky.social www.sciencedirect.com/science/arti...

A gorgeous (first of many!) paper out of the Brooks Lab (@tomorrowbot.bsky.social): www.sciencedirect.com/science/arti... Neural tube closure! Wnt signaling! Cell proliferation! Quantitative microscopy! What’s not to love?

A new 2D gene expression map of the mouse brain during early development.

Join us for the @socdevbio.bsky.social Southeast Regional Meeting, May 19-21! www.sdbonline.org/sesdb2025 Showcase your exciting research & receive valuable feedback at any stage, from a newly fertilized idea to a rapidly gastrulating hypothesis to a fully 'developed' story. 🙂 #SESDB2025 #DevBio

Excited to share the version of record of our study of patterned gene expression during the earliest stages of neural development, out now in @elife.bsky.social! A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate doi.org/10.7554/eLif...

My daily haiku from grant writing: More words fall beneath The stoke of my delete key Concision triumphs

A new single-cell atlas of gene expression provides insights into the patterning of the neural plate of mice. 🔗 https://elifesciences.org/articles/105042?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights

Pleased to present the first preprint from our group, spearheaded by the fantastic Amber Bogart. We examined the consequences of either reduced or hyperactivated Want signaling on the cellular drivers of cranial closure. www.biorxiv.org/content/10.1...