Gabriel Galea
@glgalea.bsky.social
π€ 75
π₯ 88
π 9
Neuroembryologist. Mechanobiologist. Vet.
Highly enjoyable Conversation article about a brilliant new neural tube paper:
theconversation.com/fluorescent-...
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Fluorescent quail embryos could help solve serious birth defects in humans
A fluorescent embryo allows scientists to watch living cells organise themselves in real time, revealing processes previously impossible to observe.
https://theconversation.com/fluorescent-quail-embryos-could-help-solve-serious-birth-defects-in-humans-277090?utm_medium=article_native_share&utm_source=theconversation.com
30 days ago
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Delighted with this new paper. Key findings I'm most interested in following up: - Mechanical cues impact cell shape long after the cue ends, - Surface ectoderm (SE) cells have cryptic lamellipodia which may enable collective crawling, - SE becomes progressively jammed
www.cell.com/current-biol...
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Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis
PΓ©rez-Verdugo et al. show that hindbrain neuropore closure is driven by surface ectoderm actomyosin purse-string tension and active migration. These forces create reproducible patterns of cell elongat...
https://www.cell.com/current-biology/fulltext/S0960-9822%2826%2900255-1
2 months ago
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In
@eLife.bsky.social
: Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation
doi.org/10.7554/eLif...
@hpscenthusiast.bsky.social
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https://doi.org/10.7554/eLife.110388.1
4 months ago
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reposted by
Gabriel Galea
Alex Grigas
6 months ago
How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it:
www.biorxiv.org/content/10.6...
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Sparse mesenchymal cell networks as a fluid under tension
Sparse mesenchymal cellular networks are ubiquitous across animals, shaping both embryonic and adult structures through dynamic interactions with epithelia. Yet, the physical principles underlying the...
https://www.biorxiv.org/content/10.64898/2025.12.07.692626v1
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Fascinating work on the biomechanics of mesenchymal tissues right here:
add a skeleton here at some point
6 months ago
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One for
#NeuralTube
biologists:
add a skeleton here at some point
7 months ago
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#ApicalConstriction
and
#DevBio
afficionados - we've got two new pre-prints you may be interested in, below:
about 1 year ago
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reposted by
Gabriel Galea
bioRxiv Developmental Biology
about 1 year ago
A lateral tension model for cranial mouse neural tube closure
https://www.biorxiv.org/content/10.1101/2025.05.15.654327v1
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reposted by
Gabriel Galea
James Briscoe
over 1 year ago
A couple of weeks left to apply to join Development's *Pathway to Independence* programme Support & mentoring for post-docs on the academic job market Deadline: January 31
journals.biologists.com/dev/pages/pi...
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Development PI Programme | Development | The Company of Biologists
Development PI Programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our second call for our Pathway to I...
https://journals.biologists.com/dev/pages/pi-programme-2024
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reposted by
Gabriel Galea
UCL Faculty of Life Sciences
over 1 year ago
Applications are now open for our UCL East London Scholarship. The value of the bursary is full home tuition fees plus Β£16,000 maintenance. The deadline is Thursday 26 June 2025. Find out more, including eligibility criteria:
www.ucl.ac.uk/scholarships...
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UCL East London Scholarship
This scholarship supports the ambitions of east Londoners by funding the fees and living costs of all UCL East Master's programmes and select School of Management programmes.
https://www.ucl.ac.uk/scholarships/ucl-east-london-scholarship
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reposted by
Gabriel Galea
Amoyel lab
over 1 year ago
We're hiring a postdoc! Please forward to people you know who are looking for positions. Interested in studying how metabolism is wired to support fertility? π¬πͺ° Come join us! Ad to go live next week, but informal enquiries encouraged.
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reposted by
Gabriel Galea
James Briscoe
over 1 year ago
Applications open for a new cohort of
@dev-journal.bsky.social
*Pathway to Independence* fellows Know a
#devbio
post-doc about to enter the academic job market? Would they benefit from a little support & mentoring? Spread the word Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
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PI programme | Development | The Company of Biologists
PI programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our call for our Pathway to Independence program...
https://journals.biologists.com/dev/pages/pi-programme-2025
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reposted by
Gabriel Galea
Shinuo Weng
over 1 year ago
To mark Black Friday, we are excited to share our latest work, "Planar polarized force propagation integrates cell behavior with tissue shaping during convergent extension." Now online in Current Biology.
authors.elsevier.com/a/1kATd3QW8S...
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reposted by
Gabriel Galea
Eirini Maniou
over 1 year ago
Happy to share our new preprint with Vernanda Perez-Verdugo,
@shilabanerjee.bsky.social
@glgalea.bsky.social
We show that mechanical feedback drives shape and spatial order of the surface ectoderm in hindbrain neuropore closure.
add a skeleton here at some point
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reposted by
Gabriel Galea
Shiladitya Banerjee
over 1 year ago
How do physical forces influence spatiotemporal cell patterning during tissue morphogenesis? Our latest preprint integrates theoretical modeling with live imaging of mouse embryos to reveal how mechanosensitive feedback drives self-organized cell patterning during hindbrain neuropore morphogenesis.
add a skeleton here at some point
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