A look back at the 2025 Nature Reviews Rheumatology covers, our art editor Steven Hall is brilliant🎨👏 Looking forward to the wonderful cover art that 2026 will bring!

📢 New Publication Alert! 📝 Title: The Fast-Evolving Landscape of Treatments for Calcium Pyrophosphate Deposition Disease! 👥 Authors: Vicky Tai, Charlotte Jauffret, @nicoladalbeth.bsky.social and Tristan Pascart 🔗 Read the full article here: www.mdpi.com/2813-4583/3/... #CPPD #gout

Investigating whether fractional excretion of urate (FEUA) modulates urate-lowering response to allopurinol showed that allopurinol was modestly more effective in patients with low FEUA, likely due to decreased oxypurinol renal clearance Arthritis Care & Research doi.org/10.1002/acr.... #Medsky

Colchicine initiation after gout diagnosis associated with modestly (12%) lower risk of total joint arthroplasty (vs. those who did not initiate colchicine) UK population-based cohort study (IQVIA Medical Research Database) Arthritis & Rheumatology doi.org/10.1002/art.... #Medsky

Excited to share the results of the TeMPO (Treatment of Meniscal Problems in Osteoarthritis) trial, published today in NEJM: www.nejm.org/doi/full/10.... A labor of love from the #BWH #oracore team, with partners in Buffalo, Pittsburgh, and Cleveland. 879 randomized with the COVID in the middle!

🌟Meet Dr. Francisca Sivera, the new EULAR Education Committee Chair! She assumes this role with a strong commitment to collaborating with diverse professionals to advance high-quality rheumatology training across Europe. Watch the full interview here: https://pulse.ly/p3iftscuzf

The #GCAN2025 Gold Medal Award goes to Tony Merriman of UAB for his work, his mentorship, and his service My favorite are these talks where we hear about someone's career but also their reflections on what has mattered #ACR25

Tony Merriman gives shoutout to @nicoladalbeth.bsky.social "who proudly told me last week that she would sleep through my talk" 😆 I mean, it's like 2am in NZ right now #GCAN2025

Great start to #GCAN2025 with strong representation from STOP-Gout trial, fun great debate (with hats), proud of mentee presentations, & great to see collaborators in person with #Burt @rheumcat.bsky.social @nicoladalbeth.bsky.social

Outcomes #GCAN2025 year in review Liu et al RCTs and registries for gout are not representative of the US population and tx effects may not be generalizable #ACR25

Chair Dr Bob Terkeltaub shows the growth of this meeting @g-cangout.bsky.social #GCAN2025 Thanks for continuing to have this meeting as hybrid, even if the meeting is right before #ACR25 Taking a week + out for travel is often not possible

idk, that felt like a really effective debate strategy from @nicoladalbeth.bsky.social 🧢 #GCAN2025 #ACR25

Dalbeth rebuttal: -data presented do not represent the average pt with gout Final vote: 61% vote no #GCAN2025 #ACR25

⭐CPPD nomenclature - Silvia Sirotti and Georgios Filippou We are deep in the Delphi rounds right now and I must confess I no longer remember what each P and each D stands for at this point 😵‍💫 (And I thought axSpA nomenclature discussions were wild) #GCAN2025 #ACR25

Dr. Tim Kwok emphasized that “difficult-to-treat gout” goes beyond urate levels, involving persistent inflammation, reduced function, and higher healthcare use. A holistic approach addressing clinical, patient, and system factors is key. #2025GCAN #Gout #Rheumatology

#GCAN2025 Great Debate: : The Standard Serum Urate Target in Gout Should Be < 5mg/dL for the Average Patient Pro: Thomas Bardin Con: @nicoladalbeth.bsky.social Audience pre-vote in support of the statement #ACR25

Post hoc analysis of the COLCHICORT trial (colchicine vs prednisone for acute CPP crystal arthritis) identified factors predictive of arthritis resolution. Prednisone appeared to perform better in achieving pain relief after 2 days of treatment AC&R doi.org/10.1002/acr.... #Medsky

Mouse model study found short-term intermittent fasting prevented crystal-induced inflammation & induced production of anti-inflammatory metabolites, such as ketone body BHB, corticosterone, & spermidine. Spermidine supplementation reproduced anti-inflammatory effects A&R doi.org/10.1002/art....

International survey study of people with asymptomatic hyperuricemia looked at perceptions about hyperuricemia and urate-lowering therapy. Hyperuricemia was not well understood, and most perceived minimal consequences of asymptomatic hyperuricemia AC&R doi.org/10.1002/acr.... #Medsky

Thanks to @medscape.com for highlighting our work www.medscape.com/viewarticle/...

Target trial emulations compared CV safety of NSAIDs vs colchicine among patients with gout starting allopurinol, and found NSAID prophylaxis was associated with higher risk of CV events than colchicine or no prophylaxis Arthritis & Rheumatology doi.org/10.1002/art.... #Medsky #Rheumsky

✨July Issue✨| Factors beyond urate levels for managing gout flares In this Comment article, the authors highlight the importance of considering factors beyond urate levels to prevent gout flares and improve the quality of life of individuals with gout. bit.ly/4liJVTL #Rheumsky #Medsky

Addressing patients’ expectations can enhance treatment outcomes and reduce adverse effects. This JAMA Insights offers four communication strategies to improve clinician-patient interactions. ja.ma/3Hsek2L #MedSky #MedEd

Phase 3 RCT in Chinese patients with gout showed dotinurad 4 mg/day was superior to febuxostat 40 mg/day in achieving serum urate levels ≤6.0 mg/dL at week 24. Treatment-emergent AE incidence was similar between treatment groups Arthritis & Rheumatology doi.org/10.1002/art.... #Medsky

Feels like a good time to share this - Don McGlashan playing Anchor Me last week for RNZ, a stunning version youtu.be/qlAJjSpi5T0?...

Arthritis Care & Research June Editor's Pick 👉 Gout Flares After Stopping Anti-Inflammatory Prophylaxis: A Rapid Literature Review and Meta-Analysis doi.org/10.1002/acr....

✨June Issue✨| Current challenges in understanding the epidemiology of calcium pyrophosphate crystal deposition Jauffret & Pascart highlight some of the hurdles in advancing the understanding of the epidemiology of calcium pyrophosphate crystal deposition bit.ly/4kDBPnB #Rheumsky #Medsky

Serum urate has been used as a surrogate marker for gout flares in gout clinical trial design. Commentary in A&R discusses the importance of gout flare and calls for greater focus on gout flare as a clinical trial outcome doi.org/10.1002/art.... #Medsky #Rheumsky

New installment in the A&R immunology series describes 3 broad stages of acute inflammation in gout: initiation, leukocyte mobilization, & self-resolution, and examines the role of the NLRP3 inflammasome in acute MSU crystal-induced inflammation doi.org/10.1002/art.... #medsky #rheumsky #immunosky

ICYMI: New content online:

✨April Issue✨| Hyperuricaemia and gout in the Pacific In this article, the authors provide an overview of gout and hyperuricaemia in Indigenous peoples of the Pacific region #Rheumsky #Medsky Free to read here: bit.ly/41LQgj2 🔓

✨Our April Issue is out now!✨ Featuring articles on: - Hyperuricemia and gout in the Pacific🌏 - Targeting synovial joint stem and progenitor cells🎯 - The role of the immune system in OA 🧫 - Delineating inflammatory from non-inflammatory PsA🦴 #Rheumsky #Medsky bit.ly/3FSVhxC

📣Did you know that we now publish Evidence-Based Guidelines?📣 You can view all of the EBGs that have been published in NRR using the link below (free to access!) 🔓 bit.ly/3CA9r5B

2024 In Memorium In 2024, Rheumatology lost many esteemed clinicians who cared for countless MSK patients and propelled scientific advancements impacting millions.

ADVANCE open-label trial in uncontrolled gout found response rate with pegloticase (Peg) + MTX following failed Peg monotherapy was 9%, much lower than in Peg-naive pts Results show challenge of overcoming established anti-Peg antibodies in pts with previous loss of urate-lowering response #Medsky

Potential urate-lowering approaches that employ or modulate gut microbiota and their molecules #Medsky #Gastrosky

Research Article The Significance of Intracellular Versus Extracellular Calcium Pyrophosphate Crystals in Diagnosing Calcium Pyrophosphate Crystal Arthritis 📖 www.jrheum.org/cgi/content/... #calciumpyrophosphatedehydrate #pseudogout #synovialfluid

Finally put my copy of 12th edition of Firestein&Kelley’s Textbook of #Rheumatology on my bookshelf beside the 6th edition from when I was a resident. Would never have imagined seeing my name on the cover! Add yours to your shelf! Discount code BAFF20 #FiresteinKelleyRheum12

January 2025 Arthritis & Rheumatology Editor's Pick Novel Genetic Loci in Early-Onset Gout Derived From Whole-Genome Sequencing of an Adolescent Gout Cohort doi.org/10.1002/art....

Tsai-Fan Yu was a renowned Chinese-American medical doctor whose pioneering research helped make gout a curable disease, linked gout to hypertension and diabetes, and established one of the first systematised lab tests for diagnosing rheumatoid arthritis. https://adalovelaceday.substack.com/p/pro...

Meta-analysis examined gout flare following stoppage of anti-inflammatory prophylaxis. Results showed gout flares are common after prophylaxis, but with time return to levels seen while on prophylaxis In AC&R doi.org/10.1002/acr....

ard.bmj.com/content/earl... 📣🆕 2024 EULAR points to consider on the initiation of targeted therapies in patients with inflammatory arthritis and a history of cancer #Rheumsky #Medsky

Can we finally leave the Krill to the Whales? Krill is not beneficial for knee OA! #ACR24 @rheumnow.bsky.social

Finally got a chance to watch #ACR24 Year in Review: Cipoletta et al. eval pts after 1st diagnosis gout/flare: these patients had 1.7X increased CV risk 30-120 days post-flare, stressing need for CV risk assessment and management from time of first flare @rheumnow

How is imaging tech shaping the future of gout care? Drs. Nicola Dalbeth & Dansoa Tabi-Amponsah share insights on DECT imaging & its role in achieving gout remission Listen at: sites.libsyn.com/436041/dect-... Their study in AC&R: acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Immunology for the Rheumatologist: Arthritis & Rheumatology Introduces a New Problem-Based Immunology Review Series With Great Educational Potential - PubMed https://buff.ly/4hZt0nN I learned A&R started this immunology series.

Woke up and realized that @rheumnow.bsky.social is here now🙌 I was checking through their article and YouTube to catch up #ACR24 📺☺️ #Rheumsky ❤️

And I found this old tweet from @philipcrobinson from the first @ACRheum I attended in 2016, and it reminds me of why we do what we do, and what this program is about @jyazdanymd.bsky.social @profbeckyg.bsky.social @nicoladalbeth.bsky.social

We are delighted to announce that the Best PhD Thesis award is open! We are inviting young scholars to send us their applications! You have to have defended in 2024. The process is open from November to May! 📷 For more information: mdpi.com/journal/gucd...

#0178 Dalbeth 🦶 Phase 3 gout trials 2009-2023, n=12 trials Looked at age, sex, eth vs NHANES distributions 👉 Found under-representation of women, older individuals, non-Hispanic White individuals, and those with comorbidities, in gout trials #ACR24