‘If we’re not at the table, we’re on the menu’ FULL SPEECH: Canada’s PM Carney Says US-Led World Order Is Breaking at World Economic Forum | AC1G - YouTube www.youtube.com/watch?v=dTvF...

Reproducible Research Workflow shibakoichiro.github.io/20260120-rep...

This is what happened in our neighborhood yesterday. ICE snatched a human being off of our streets, roughed them up badly, and then pepper sprayed legal observers as they documented it all. This is a daily occurrence happening all throughout Minnesota right now.

DMOAD has arrived!?: Biosplice Announces the Submission of its New Drug www.globenewswire.com/news-release...

Marco Rubio is reportedly saying Maduro will stand trial in US courts. Which means it’s now the US administration’s position that US courts can hold foreign presidents, but not the US president, accountable for crimes.

The CDC Shooting Isn't What Broke Me | MedPage Today www.medpagetoday.com/opinion/seco...

The Wisconsin component of the analysis here is revealing. Evidence is consistent with DOGE strategically delaying contract terminations in WI until after the 2025 state Supreme Court elections to mitigate electoral risk.

New Targeted Therapies for Sjögren’s Disease and Diagnostic Advances in 2025 | Vumedi

Korean plush toys for kids

12 former commissioners of the FDA came together to write a Perspectives piece for the New England Journal of Medicine; raising our concerns about recent changes to vaccine approval policy at the FDA and its implications for patients and public health.

The Thinking Game | Full documentary | Tribeca Film Festival official selection www.youtube.com/watch?v=d95J... Really interesting documentary I randomly found during air travel

The rapid growth in Mendelian randomization studies | European Journal of Epidemiology link.springer.com/article/10.1...

"More than 70 percent of the MBTA’s rapid transit stops [...] have at least one Bluebikes docking station within 200 meters. With this overlap, a Bluebikes ride can cover the first or last mile of a multimodal commute to extend the range of MBTA trips [...]"

E-bikes are supercharging the Bluebikes system - and that's a good thing   - CommonWealth Beacon commonwealthbeacon.org/opinion/e-bi...

Obinutuzumab, REGENCY, & Updates in Lupus Nephritis, With Brad Rovin, MD pca.st/episode/ef70...

Democrat Michelle Wu has been re-elected Mayor of Boston.

What target cell(s) important for rheum disease? -T cells: because lots of antimetabolites we use work here -B cells: but would this only work for RTX responsive diseases? -plasma cells? -myeloid cells? Steroids, IL-1i, IL-6i are targeting here #ACR25

Drug development looks simpler from the onc viewpoint than rheum -mechanisms better understood -dx is done with bx -trials have uniform criteria -risk tolerance is different (clinicians and patients) -trying new things is more accepted #ACR25

Marcela Maus took the BCRC to the finish line by talking about CAR-T study design for rheum with lessons learned from onc #ACR25

#ACR25 - Sunday Plenary I 🌟

Abs 0772 Petri et al ❓ Are guidelines for kidney bx missing LN? They use a threshold of UPCR >= 0.5g/g In this study they looked at patients with SLE + UPCR 0.25-0.44g and did kidney bx. 👨‍👨‍👦 N=28; 20 ultimately diagnosed with LN. 🤔 Should the threshold for kidney bx in SLE be lowered? #ACR25

Abs 0776 Schmidt et al 💊 2 year outcomes of the SELECT-GCA RCT studying UPA 👨‍👨‍👦 N=181 re-randomized to continue UPA vs switch to PBO 69% continuing UPA maintained remission vs 29% switched to PBO UPA 15mg dose was a/w lower frequencies of serious infx but higher herpes zoster #ACR25

This is several days old. But amidst so much else id missed it. That’s a stunning number. No wonder they about-faced. Reminder of the power of consumers in oligarch era, not subject to the same kind of targeting.

#TodayinHistory #dataviz #OTD 📊 💀Oct 25, 1914 Wilhelm Lexis died in Gottingen, Germany 🇩🇪 1875: The Lexis diagram, showing relations among age (cohort), calendar time, and life spans of individuals simultaneously. Revolutionized demography, making key variables visible

Monstrous.

JUST IN: The White House has begun DEMOLISHING portions of the East Wing of the White House to build Trump’s $250 million ballroom — despite earlier claiming it wouldn’t “interfere” with the existing White House structure. (Washington Post)

It’s not his house. It’s your house. And he’s destroying it.

The White House is asking people not to share pictures of the East Wing because it’s even worse today.

Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis www.nejm.org/doi/10.1056/...

BREAKING NEWS: The FDA has approved Gazyva® (obinutuzumab) for the treatment of adults with #lupus nephritis. Gazyva is the fourth therapy for lupus to receive regulatory approval since 2011. Read the announcement: buff.ly/81tYgo7

Happy to announce that I'll give a talk on how we can make rigorous causal inference more mainstream 📈 You can sign up for the Zoom link here: tinyurl.com/CIIG-JuliaRo...

World War 2 veterans, the original antifa, took part in the nationwide protests against the fascist Trump regime. #3E #NoKings #50501Movement #indivisible #wearetheflood

Erdos AI IDE for Data Scientists | Lotas www.lotas.ai/erdos looks like an interesting tool for exploratory analyses at least

I’m on a low-fiber diet for screening colonoscopy and I’m craving for my usual fresh fruits and nuts diet…

"It is much more important to know what sort of a patient has a disease than what sort of a disease a patient has." – William Osler

ggplot2 4.0.0 www.tidyverse.org/blog/2025/09...

Bike lanes

Lego Land in Boston

V5 White at #rockspotclimbing

My colleague found me biking to work and sent me a picture

[General]: On Sequoia 15.1 (Intel) Emacs.app does not run and has permissions errors · Issue #742 · d12frosted/homebrew-emacs-plus github.com/d12frosted/h...

Demystifying Clone‐Censor‐Weighting to Studying Treatment Initiation Windows: An Example Using Publicly Available Synthetic Medicare Claims Data - Webster‐Clark - 2025 - Pharmacoepidemiology and Drug Safety - Wiley Online Library

Mole toys from Prague (en.m.wikipedia.org/wiki/The_Lit...)

America Is on the Cusp of a Two-Tier Vaccine System - The Atlantic

ABC’s suspension of Jimmy Kimmel Live! triggered a flood of Disney+ subscription cancellations, briefly overwhelming the cancellation webpage itself. open.substack.com/pub/beinglib...

Even with supposed clarity that this $100k fee is only for new H1B visa applications, there is a total lack of clarity right now (over a weekend, since this was a 5pm Friday EO) for what happens to current H1B visa holders in the US. This chaos is more cruelty.

Muzeum Station, Prague

Saphnelo self-administration TULIP-SC Phase III trial meets primary endpoint in SLE | The Pharmaletter (lupus trial being reproducible is amazing)

I didn’t know about this, and if I didn’t know about this, then you probably didn’t either. This should be my entire feed and it’s not and that’s a problem  This sit in has now been going on over 48 hours and I am just hearing about it now 1/