🥳 We are excited to share the first publication from the Bohlen Lab! "Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B but not T cell development and function" www.nature.com/articles/s41... together with the Tangye Lab and @bloodgenes.bsky.social and many more! 1/n

We're proud to announce that infectious disease pioneer Jean-Laurent Casanova, MD, PhD, of @rockefeller.edu, @institutimagine.bsky.social, @hhmi-science.bsky.social, & @casanovalab.bsky.social, is the recipient of the 2026 Mechthild Esser #NemmersPrize in Medical Science: spr.ly/6008hCUaM

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

Human inherited integrin αL deficiency selectively impairs skin homing of T cells and surveillance of commensal papillomaviruses @sciimmunology.bsky.social www.science.org/doi/10.1126/... @casanovalab.bsky.social

Saidoune, Gilliet , @ahmad-yatim.bsky.social et al. show that excessive TLR7 responses to #SARSCoV2 by pDCs are linked to I-IFN–driven chilblain development. rupress.org/jem/article/... From our Pattern Recognition Receptors & Beyond #InnateImmunity collection: rupress.org/jem/collecti...

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1/ I was honored to accept the 2025 Novo Nordisk Prize from @novo-nordisk.bsky.social at today’s award ceremony in Copenhagen, Denmark. It was a wonderful day that included a tour of The BioInnovation Institute, lunch at @novo-nordisk.bsky.social, and an evening award celebration and dinner.

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains, say Fanny Saidoune, Michel Gilliet, Ahmad Yatim (@ahmad-yatim.bsky.social) @casanovalab.bsky.social and colleagues: rupress.org/jem/article/... #SARSCoV2 #COVID19

#WeekendRead! #MysterySolved! Saidoube @casanovalab.bsky.social Gillet @ahmad-yatim.bsky.social &co show @jem.org that excessive TLR7 activation in pDCs drives type I #Interferons protecting against SARS-CoV-2 but at the same time causing chilblains! rupress.org/jem/article/...

1/ One of the most intriguing enigmas of the #COVID19 pandemic was the sudden and unprecedented outbreak of chilblains that accompanied the early waves of #SARSCoV2 infections. Our new study in @jem.org uncovers the underlying immunological mechanism rupress.org/jem/article/...

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains @jem.org @casanovalab.bsky.social rupress.org/jem/article/...

Chilblains were reported in #SARSCoV2–exposed individuals without PCR- or serologically defined #COVID19. Saidoune, Gilliet , @ahmad-yatim.bsky.social et al. show that excessive TLR7 responses to SARS-CoV-2 by pDCs are linked to I-IFN–driven chilblain development. rupress.org/jem/article/...

1/ I am both delighted and relieved to share my inaugural editorial for the @jhumimmunity.org rupress.org/jhi/article/...

Excited to launch this new journal with a great team, and the support of both RUP and IAPIDS, and the entire community of human inborn errors of immunity !

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼