Just to be clear, this is a violation of the fundamental ethical principle in clinical trial design called "equipoise." Equipoise means that no-one is exposed to excess risk just to test the therapy. That's specifically *why* vaccine trials don't use placebo arms. Ethical violation as POLICY.

Really can’t believe the dumbness of the moment we are in. Let’s remove info that will keep people safe and replace it with claims that have no bearing on public health right now.

Explain to me why encroaching on the second amendment is not allowed even when children’s lives are at stake but the first amendment is easily eroded when someone simply disagrees with our President.

I have this radical lefty belief that voting should be easier than buying a gun.

open.substack.com/pub/pauloffi... RFK Jr. is set to derail progress on the causes of autism.

The House just passed its budget resolution, so reconciliation is now officially underway. This is their bill to destroy Medicaid and SNAP while cutting taxes disproportionately for the rich. THIS IS VERY REAL and can be enacted even if all Ds vote no. Thread on what's to come and WHERE TO FIGHT.

I suspect that RFK Jr.’s claim that he will know the cause of autism by September is driven by a rigorous protocol of policy-based evidence making, a term I first learned from @joho.bsky.social. He’s just gonna make shit up to “prove” he was “right”.

This is not how science works. You can’t promise you’re going to find an answer to a question unless you don’t follow the scientific method & rig it to get the answer you want, which i am sure is exactly what is happening. No matter the findings of this “study”, vaccines cause adults, not autism

The four women on SCOTUS dissented. I think that's very indicative of why we are here today.

From Nov 7:

I'm sorry, but isn't this just the Cultural Revolution 2.0? Why on earth would fired aid workers and NIH medical researchers go to work on assembly lines for worse salaries in jobs they don't know how to do? Why are they getting their economic policy from Mao?

It’s a recalibration of economic control. Oligarchs don’t live paycheck to paycheck. They have the capital to buy market dips and recoup faster, acquiring more assets at fire sale prices along the way. When the dust finally settles, they will own more. The rest of us will own less. A lot less.

Sign of the day…

Is this who we are? 😳🇺🇸

Full disclosure. I missed the memo on yesterday’s protests happening. I imagine I’m not alone, so the resistance is even bigger than those who marched yesterday. When do we march again?

If you are an NC resident and voted in November, please check if your name or the names of any family areone of the 60K votes being challenged. If so, confirm ASAP with your Board of Elections. You only have two weeks. The website to check linked in the reply. www.newsobserver.com/news/politic...

More examples of how we are clearly not “winning” and all signs point to these stats getting a lot worse in coming yrs as US biomedical research infrastructure is dismantled and the economy collapses from tariffs.

"A local ER physician was in the break room Thursday when he heard Gov. Ned Lamont announce “devastating” federal cuts of more than $150 million to Connecticut public health programs" www.ctinsider.com/connecticut/...

This is an important 🧵🧵 🧵

Thanks Wisconsin! Very relieved that Musk wasted $25 million. Granted it is a pretty meaningless sum of money to him and he’s going to make it all back, and the some, with Trump’s tax cuts for billionaires. But oligarchs can’t win if the rest of us stand up. Keep going.

Don’t get me wrong, what Cory Booker did was great and we need more of that energy. But also I can’t help but think about all the 28hr calls I did in residency. What if the Senate Dems treated the next 4 yrs like residency and did 24hr call and just didn’t stop talking 24/7/365

Senator Booker is still going 👊🇺🇸🔥 www.youtube.com/live/rCUK2Vb...

Really hoping the folks of the great state of Wisconsin get out and vote today to send a message that oligarchs can’t just buy elections

Spelling and grammar are woke.

Read This. But also, the idea this was just some “administrative error” is ridiculous. This was cruel, targeted, and purposefully designed to avoid judicial review, since no judge would have allowed this to proceed.

Thank you @nytimes.com for this gem of a photo of JD Vance. I can see this being repurposed in memes for years to come

Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs. Find out how your community may be impacted. Explore more at SCIMaP: scienceimpacts.org a 🧵

It took a lot of stupid to alienate Canada but we did it

Abrupt cancellations of grants like this is never how the government has functioned This means people lose their jobs with no warnings These people, while unserious, make decisions that have serious consequences for normal humans and frankly they don't give a shit about you

I wish people hated fascism half as much as they hate feminism

This is exactly what we knew would happen. Science is being replaced by quackery masquerading as “science” that will cause irreparable harm

Reading comments on the Fox News website is usually something that I do to torture myself, but seeing the responses to the articles about the Signal debacle is giving me hope. Nearly everyone except the most insane realize this was very very bad and aren’t buying the spin coming from the White House

If I was accidentally cc’ed on war plans I’d have a hard time not replying all over and over again with a torrent of messages asking to be removed from this listserv

What happens next feels like a true test for whether we still live in a democracy or a totalitarian regime. And I’m not liking the odds that accountability and justice actually happen. Every Dem (and GOP) congressperson needs to be demanding an investigation NOW.

How many Signal chats with sensitive information about military operations are ongoing within the Pentagon right now? Where else are war plans being shared with such abject disregard for our national security? We need answers. Right now.

👇👇👇

“👊🇺🇸🔥” is such a funny way to signal the death of this country

As someone who spends a lot of time thinking about the appropriate vs inappropriate use of secure text messaging between healthcare clinicians, I find this insane disclosure of war plans on a group chat pretty hilarious

Pete Buttigieg breaks down DEI for everyday folks… “The opposite of diversity is uniformity. The opposite of equity is inequity. The opposite of inclusion is exclusion.” @petebuttigieg.bsky.social Our problem: too many value uniformity over inclusion and they’re the ones running the government. 🧵

There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University & academic career... 1/🧵

Yes. This is the death of US biomedical research by weaponizing administrative burden. It’s the GOP playbook— they have long increased admin burden in red states to defund Medicaid, unemployment, and other safety net programs they don’t like. See @donmoyn.bsky.social Now they want to privatize NIH.

ICYMI: Addressing Alert Fatigue by Replacing a Burdensome Interruptive Alert with Passive Clinical Decision Support www.thieme-connect.com/products/ejo... #MedSky #CDS @annefallon.bsky.social

Dr Alawieh is a kidney doctor who works with patients who get kidney transplants. She trained at Yale. She works at the VA, treating American vets. She had a passport and visa. And she is being detained without a lawyer. www.providencejournal.com/story/news/l...

One cool thing about the United States is that there are more people whose job is to deny healthcare coverage without having any medical background than there are people to provide healthcare coverage and they’ve somehow convinced people that the doctors are where the monetary waste is happening

Correct. Science is a long-term endeavor. It requires building talent and groups over time. And giving them space to think about hard questions and find answers. The current chaos caused by Trump and Musk is setting America back by years.

A lot of global academic conferencing is centered around the US, and US academic orgs have to be thinking very seriously now. You cannot continue to carry on with in person conferencing as if foreign scholars have no impediments to travel. I know we like to pretend everything is "normal" again but..