The old version and the new (Powerpoint-friendly, content edits by @alhkim.bsky.social ) version of the lupus overview graphic ~ #MedSky #RheumSky (do we still use hashtags here? i feel old 👵)

Recording an episode of @freelyfiltered.bsky.social with @kidneyboy.bsky.social and @jenniejlin.bsky.social with special guests @alhkim.bsky.social Koyal Jain and Brad Rovin No surprises on what recent #NephJC study we are discussing 👑

NIH indirects case update: Hearing ongoing now, and I'll try to live tweet some notable exchanges. Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides: (I'm paraphrasing here)

COMING UP at 10am, the preliminary injunction hearing in the consolidated Boston cases against NIH (Mass v., AAU v., AAMC v.). Oral argument time is divided thus:

🆕 #Obinutuzumab (Obi) in Lupus Nephritis: the REGENCY Trial Phase 3 RCT: Obi vs PBO 🫘 Pts w/ SLE nephritis Class III/IV ± 5 🎲 Randomized 1:1 to OBI v PBO (+MMF/steroids) 📊 Obi: ⇡rate of renal response and improved renal outcomes #LupusNephritis #RheumSky #NephSky #MedSky #Lupus

This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this? grants.nih.gov/grants/guide...

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

This is a massive hit to academic medical centers - probably unilaterally cuts their NIH dollars by 20%. Lots of folks are going to lose their jobs:

Last year 90% of members of the US Air Force didn’t even fly planes! MaSIvE GOverNMeNt wAsTE!! Or - they do all the other essential things to keep the mission running, including really boring things like cutting paychecks, cooking, and even being pediatricians to airmen/women’s kids

Holy shit…ALL indirect rates for NIH grants slashed to 15% (if I’m reading this correctly?) grants.nih.gov/grants/guide...

I’ve seen this film before. @alhkim.bsky.social @jeffsparks.bsky.social @kristenyoung.bsky.social @situationrheum.bsky.social

“A group of researchers and students at the Harvard T.H. Chan School of Public Health is gathered today for a data preservation marathon, scraping and downloading data related to health equity from U.S. government agency websites before they disappear.”

This is a big deal, y'all. Federal health websites are being stripped of content or removed in their entirety. Stick with this thread for a look at what's disappeared so far! 1/x

What pediatric rheumatology workshop would adult rheumatologists find most useful at a conference?

🎆4 years in the making! Thrilled to share the 1st spatial single cell aging clock ⏰ www.nature.com/articles/s41... We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠 Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧵

Look who’s migrated over to @bsky.app: @zahitouma.bsky.social!! You better give him a follow.

If you want to understand why healthcare pricing is horrific, the first thing to know is that our system puts 100% of the credit risk for deductibles, copays and co-insurance on hospitals and doctors. That's insane. We have turned them into Sub Prime Lenders 🧵

Andrea continues to delve deeply into the utility of urinary biomarkers for lupus nephritis. We both provide deeper insight into this massive unmet need in lupus nephritis on @medpagetoday.bsky.social: nam10.safelinks.protection.outlook.com?url=https%3A...

Surprise case of immunotactoid glomerulopathy in a biopsy for longstanding proteinuria thought to be due to chronic HTN. ~30nm microtubular structures. IgG2-kappa restricted. MGRS lesions, often associated with lymphoma bit.ly/3NNpwVd. #renalpath #pathsky #nephsky

Our latest paper is out, led by Dr Vanessa Kronzer- Using data from the Mayo Clinic and Mass General Brigham Biobanks, we found strong gene-respiratory disease interactions for risk of rheumatoid arthritis ard.bmj.com/content/earl...

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

🗣️GO TO SLEep!🗣️ My first and best advice to my patients was captured in this #ACR24 gem, “Chasing Zzzs in Rheumatic Disease…” by dear friends @alhkim.bsky.social @yvonne-lee.bsky.social and Patty Katz. Let’s get into it!

#ACR24 lupus nephritis guideline puts nickel down on choosing CNI if proteinuria >3 grams based on post-hoc analysis of BLISS-LN. Hopefully a head-to-head comparison of adding BEL or CNI or OBI will happen at some point

Targeting autoreactive TRBV9+ T cells using TRBV9xCD3 bispecific T cell engaging antibodies. Controlling ankylosing spondylitis and celiac disease without increasing the risk of infection? Let's go. Join us at Room 150, 3:00 PM. #precisionimmunotherapy #ACR24

While at it, if you are interested in learning more about off-the-shelf precision immunotherapies for the treatment of lupus, please join our talk on 9G4xCD3 T cell-engaging antibodies during the SLE - Cellular Therapy Session at 3 PM. #ACR24

I’ll be presenting at 3pm in Ballroom B (1755) on “Single Cell TCR Sequencing Suggests Potential Limitations of TRVB9-depleting Therapies in Axial Spondyloarthritis”. Would love to chat about our work if you stop by! @washumedrheum.bsky.social #ACR24

I found @alhkim.bsky.social and he has the F F F bracelet @laceyfeigl.bsky.social #ACR24

#ACR24 plenary preview / highlights