Jan M. Ache
@jan-ache.bsky.social
š¤ 231
š„ 209
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pinned post!
Thrilled to start 2026 with our latest preprint, in which we dive into a dedicated forward-walking circuit in the fly brain:
doi.org/10.64898/202...
. This effort was spearheaded by the fantastic
@chrisjdallmann.bsky.social
with help from a bunch of talented people in the lab.
add a skeleton here at some point
2 months ago
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Jan M. Ache
Junior European Drosophila Investigators
15 days ago
The registration is open! Junior
#Drosophila
PIs, join us for inspiring scientific discussion, contribute a talk and listen to our keynote speaker, Eugenia Chiappe. We meet in Palmela, Portugal from June 1st to 3rd. Register soon as spots are limited!
congressos.mundiconvenius.pt/geral/inseri...
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New registration
New registration
https://congressos.mundiconvenius.pt/geral/inseririnscricao.aspx?evento=176&formulario=317&lingua=en-GB
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Jan M. Ache
Carolina Rezaval
22 days ago
Our new preprint is out! A state-dependent neural circuit resolves approachāavoidance conflicts
www.biorxiv.org/content/10.6...
Fantastic work led by Devika Bodas, with key contributions from Marine Balcou, and a great collaboration with Lisa Scheunemann Lab, fearuting Åevval Demirci.
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https://www.biorxiv.org/content/10.64898/2026.02.05.704045v1Fantastic
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Jan M. Ache
Casey Schneider-Mizell
about 1 month ago
This video on Avatar 2/3 reignited this feeling:
youtu.be/ueJTdtmZ5R4?...
. Weta Workshop wanted to transfer actor faces to CGI Na'vi faces, which have different facial structure. So they built an anatomically inspired facial muscle model and fit it using gaussian splat meshes from video.
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VFX Artists React to Bad & Great CGi 211 Ft. Joe Letteri
YouTube video by Corridor Crew
https://youtu.be/ueJTdtmZ5R4?si=Qew0A_Cp-Fm75ZC8
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Jan M. Ache
Chris J Dallmann
2 months ago
Wonderful team effort with
@jan-ache.bsky.social
, Fathima Iqbal,
@sirinlieb.bsky.social
,
@merterginkaya.bsky.social
,
@sanderliessem.bsky.social
, and others. Thanks to
@erc.europa.eu
#HorizonEurope
#MSCA
and
@dfg.de
for funding.
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Thrilled to start 2026 with our latest preprint, in which we dive into a dedicated forward-walking circuit in the fly brain:
doi.org/10.64898/202...
. This effort was spearheaded by the fantastic
@chrisjdallmann.bsky.social
with help from a bunch of talented people in the lab.
add a skeleton here at some point
2 months ago
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reposted by
Jan M. Ache
Clara Howcroft Ferreira
2 months ago
Happy New Year from seasonally beautiful Newcastle-upon-Tyne! Get in touch if you are interested in our
#PhDstudentship
to research the neurobiological basis of social behaviour and its dysfunction in Drosophila melanogaster. Deadline for applications: 23rd January.
add a skeleton here at some point
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Jan M. Ache
Johannes Felsenberg
3 months ago
Carolin Warnecke together with Hanna, Dennis, Bene & Kerstin from my lab show that re-exposure to reward diminishes multiple associated olfactory memories. Weāre hiring 2 postdocsāDM/email me for details.
#Postdoc
#Hiring
www.sciencedirect.com/science/arti...
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Re-exposure to reward re-evaluates related memories
To adapt behavior in changing environments, animals must continuously re-evaluate previously learned associations. This flexibility of memory systems ā¦
https://www.sciencedirect.com/science/article/pii/S0960982225015969
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How do animals channel sensory information into motor pathways to generate flexible behavioral output? Excited to share a new preprint addressing this question by leveraging the new
#maleCNS
connectome, behavioral experiments, and in-vivo recordings:
doi.org/10.64898/202...
. A longš§µ...
3 months ago
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Jan M. Ache
Richard Benton
3 months ago
Deadline for this post-doc position in my lab extended to Jan 11th!
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Happy to share our current opinion on the insulin and octopamine systems and their role in shaping neuronal circuits, energy homeostasis, and behavior in
#Drosophila
, other insects, and š§āš¦±.
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4 months ago
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Jan M. Ache
Greg Jefferis
5 months ago
Exciting news for
#drosophila
#connectomics
and
#neuroscience
enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators
www.janelia.org/project-team...
.
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Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system āa seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
https://www.janelia.org/project-team/flyem/male-cns-connectome
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Jan M. Ache
Chris J Dallmann
6 months ago
Now out in
@nature.com
: Our study discovering a neural circuit in Drosophila that predictively inhibits proprioceptor axons during voluntary leg movements, such as walking and grooming.
www.nature.com/articles/s41...
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Couldnāt be more excited about this paradigm shifting result.
6 months ago
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reposted by
Jan M. Ache
Gizem Ćzdil
6 months ago
šŖ° How do dozens of tiny fly muscles cooperate to move a leg? Weāre excited to share the first 3D, data-driven musculoskeletal model of Drosophila legs based on Hill-type muscles, running in OpenSim and MuJoCo simulation environments. Preprint:
arxiv.org/abs/2509.06426
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Jan M. Ache
The Transmitter
7 months ago
FlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employeesā salaries was canceled. Scientists warn that losing FlyBase could devastate fly research. By
@claudia-lopez.bsky.social
www.thetransmitter.org/community/ha...
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Harvard University lays off fly database team
The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.
https://www.thetransmitter.org/community/harvard-university-lays-off-fly-database-team/?utm_source=mastodon&utm_medium=org-social&utm_campaign=20250813-harvard-lays-offs-fly-database
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Preprint Alert! Walking mostly feels natural and easy to us - but the neuronal control of walking is actually incredibly complex. We leveraged the fruit fly as a genetically tractable animal model with a compact nervous system to ask how the brain controls walking direction:
tinyurl.com/flywalk
. š§µ..
7 months ago
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Jan M. Ache
Kevin Mitchell
8 months ago
This isn't a coincidence, IMO. The fly community is generally super rigorous - because there are so many tools and techniques available, people expect you to really nail things in order to get published (and keep getting funded)
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Jan M. Ache
Carolina Rezaval
8 months ago
We're hiring! Two exciting opportunities in our Lab
@unibirmingham.bsky.social
Come work with us on decision-making and neural circuits in Drosophila. Please share! Senior Research Technician + Postdoctoral Research Fellow Deadline: 10 July More info here:
www.rezavallab.org
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Very happy to share that the awesome
@merterginkaya.bsky.social
was awarded a
@dfg.de
#WalterBenjamin
scholarship for his postdoc project on mechanisms for action-selection in visual sensorimotor pathways. The more Mert the better. š
8 months ago
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Itās a wrap for the 2025 Crete Fly Circuits meeting! Huge thanks to our friends at the OAC for hosting us, our fantastic speakers for sharing their latest and greatest unpublished works, and to Eugenia, Marion, Nilay, and Richard for the fun we had organizing this. See you all in 2027!
9 months ago
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Jan M. Ache
Stephen F. Goodwin
9 months ago
New preprint from lab:
www.biorxiv.org/content/10.1...
Sexual dimorphism arises not through wholesale transcriptional reprogramming, but via selective sex-specific survival of neurons defined by birth order and shared developmental programs.
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A Role for Exaptation in Sculpting Sexually Dimorphic Brains from Shared Neural Lineages
Sex differences in behaviours arise from variations in female and male nervous systems, yet the cellular and molecular bases of these differences remain poorly defined. Here, we take an unbiased, sing...
https://www.biorxiv.org/content/10.1101/2025.06.04.657833v1
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The sky knows whatās up. Happy
#pridemonth
! š
9 months ago
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Very happy that we were able to contribute a few recordings from our favorite
#insulin
producing cells to this great story from
@buelowlab.bsky.social
!
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9 months ago
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Jan M. Ache
Salil Bidaye
10 months ago
Hey spinal/ventral nerve cord folks. weāre organizing this cross species ācordsā meeting
@hhmijanelia.bsky.social
. Hurry up and upload your abstracts. As a trainee these were my favorite meetings (small and focused) where I got the most useful feedback. DM in case of any Qs.
add a skeleton here at some point
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Jan M. Ache
Pingkalai R. Senthilan
10 months ago
#CharlotteFƶrster
#Farewell
#Symposium
#Chronobiology
#GermanClockClub2025
#CircadianClock
#Drosophila
#Fruitfly
#Würzburg
#KatharinaBeer
#RudolfoCosta
#BambosKyriacou
#OrieSchƤfer
#MonikaStengl
#SheebaVasu
#TaishiYoshii
#CharlotteHelfrichFƶrster
#Circadia_Clock
@uni-wuerzburg.de
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Jan M. Ache
Mert Erginkaya
10 months ago
Excited to share my PhD paper is out! We studied how motion vision is processed beyond the optic lobes to help flies walk straight. It has been a wonderful collaboration with
@michaelreiser.bsky.social
,
@dddavi.bsky.social
and many others not in bluesky! Paper + digest here:
bsky.app/profile/cham...
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I could not be more proud to present the the first PhD graduate from my lab -
@ritujabisen.bsky.social
! Rituja basically walked into an empty lab in the beginning of 2020, helped build the labās first ephys rig from scratch, and then patched her heart out over the following yearsā¦
10 months ago
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Yay - the extensive review Ansgar Büschges and I wrote on insect motor control and the many things insects can teach us about our own nervous systems just came out in Physiological Reviews
@apsphysiology.bsky.social
. Check it out - it's free:
journals.physiology.org/doi/epdf/10....
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Motor control on the move: from insights in insects to general mechanisms
https://journals.physiology.org/doi/epdf/10.1152/physrev.00009.2024
11 months ago
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Jan M. Ache
Tim Barnes
11 months ago
the Dunkinā logo has never felt more accurate
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Jan M. Ache
Clara Howcroft Ferreira
about 1 year ago
Join us for a fully funded, 4-year PhD, a collaboration between Northumbria, Durham and Mainz Universities to study the evolution of the neuronal basis of defence behaviours in Drosophila! Application and full PhD advert:
www.findaphd.com/phds/project...
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Jan M. Ache
Michael Reiser
11 months ago
I know there's a ššš going on right now, but I couldnāt be prouder to share this long-incubated labor of love: the complete connectome of the male š·ššš ššāššš optic lobe š§ šŖ° š
www.nature.com/articles/s41...
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Connectome-driven neural inventory of a complete visual system - Nature
A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.
https://www.nature.com/articles/s41586-025-08746-0
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Jan M. Ache
Sirin Liebscher
12 months ago
I'm very excited to share joint work from the project I have been working on with great colleagues during the first year of my PhD. You can hear all about it tomorrow at 11:00 in Symposium 11 - Wired for motion: perspectives on motor control.
@neurowissg.bsky.social
#NWG2025
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The labās getting ready for the NWG meeting 2025
@neurowissg.bsky.social
! Our plotting service
@uni-wuerzburg.de
was so excited about the work of
@sirinlieb.bsky.social
that we got six copies of her poster - make sure to check out what all the hype is aboutā¦
12 months ago
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Our third paper on the neuronal control of insulin release in flies was published in
@elife.bsky.social
! This was a great team effort spearheaded by Tina Held, Rituja Bisen and our collaborator
@zandawala.bsky.social
. You can find the paper here:
elifesciences.org/articles/99548
. 1/3
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Aminergic and peptidergic modulation of insulin-producing cells in Drosophila
The combination of receptor expression analysis, optogenetics, physiological approaches, and connectomics reveals how a heterogeneous population of insulin-producing cells in Drosophila integrates div...
https://elifesciences.org/articles/99548
12 months ago
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www.theatlantic.com/politics/arc...
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The Trump Administration Accidentally Texted Me Its War Plans
U.S. national-security leaders included me in a group chat about upcoming military strikes in Yemen. I didnāt think it could be real. Then the bombs started falling.
https://www.theatlantic.com/politics/archive/2025/03/trump-administration-accidentally-texted-me-its-war-plans/682151/
12 months ago
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Jan M. Ache
Rebecca Fielding-Miller
12 months ago
Today I lost an NIH grant training clinicians to do research about intimate partner violence with perinatal women. More women are murdered in the perinatal period than die of obstetric complications. I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.
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Jan M. Ache
Graziana Gatto
about 1 year ago
Registration started for the Janelia meeting on spinal cord and brainstem circuits for sensorimotor adaptation across species. Spinal cord is more than a hub, it does supercomputing!
www.janelia.org/you-janelia/...
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Computing Cords: Sensorimotor Control by Nerve Cord Circuits Across Species
Organizers Salil Bidaye, Max Planck Florida Institute for Neuroscience Ansgar Büschges, University of Cologne Graziana Gatto, University of Cologne Abdel El Manira, Karolinska Institutet Julie
https://www.janelia.org/you-janelia/conferences/computing-cords-sensorimotor-control-by-nerve-cord-circuits-across-species
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Very happy to share the latest paper from the lab, which just got published in eLife in its final form:
elifesciences.org/articles/98514
This project was spearheaded by PhD student extraordinaire Rituja Bisen, with help from Fathima Iqbal, Feffo Milani, and our visiting scientist Till Bockemühl.
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Nutritional state-dependent modulation of insulin-producing cells in Drosophila
An in vivo electrophysiology approach identifies an incretin-like effect in Drosophila insulin-producing cells, highlighting key circuit dynamics which govern glucose homeostasis via conserved mechani...
https://elifesciences.org/articles/98514
about 1 year ago
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reposted by
Jan M. Ache
Julius-Maximilians-Universität Würzburg
about 1 year ago
The
#insulin
system of the fruitfly
#Drosophila
is very similar to that of humans.
@jan-ache.bsky.social
now reports new findings on the mechanisms controlling insulin release in live flies
@elife.bsky.social
. ā”ļø
www.uni-wuerzburg.de/en/news-and-...
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Jan M. Ache
eLife
about 1 year ago
Fruit flies have a different type of blood to us, and their insulin comes from neurons instead of pancreatic cells. But important similarities mean scientists could use them to better understand human health.
https://elifesciences.org/digests/98514/a-closer-look-at-insulin-producing-cells?utm_sourā¦
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A closer look at insulin-producing cells
New research sheds light onto the mechanisms controlling insulin release in live fruit flies, highlighting important similarities with humans.
https://buff.ly/4jxBxzb
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Jan M. Ache
eLife
about 1 year ago
The activity of insulin-producing cells depends on the nutritional state in Drosophila.
https://elifesciences.org/reviewed-preprints/98514?utm_source=bluesky&utm_medium=social&utm_campaign=organic
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