🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇

Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club. Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...

It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@cp-cellbiomat.bsky.social, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"! 🔓 : www.cell.com/cell-biomate...

Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology (@natchembio.nature.com)! Check it out! 📜: www.nature.com/articles/s41... @uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...

Singh, A., Thale, S., Leibner, T., Lamparter, L., Ricker, A., Nüsse, H., Klingauf, J., Galic, M., Ohlberger, M., & Matis, M. (2024). Dynamic interplay of microtubule and actomyosin forces drive tissue extension. Nature communications, 15(1), 3198. #EpithelialMechanics buff.ly/Nwi5TVv

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend. mpl.mpg.de/news/article... @fau.de 📸 Stephan Spangenberg

Harris, A. R., Peter, L., Bellis, J., Baum, B., Kabla, A. J., & Charras, G. T. (2012). Characterizing the mechanics of cultured cell monolayers. Proceedings of the National Academy of Sciences of the United States of America, #EpithelialMechanics doi.org/10.1073/pnas...

My very dear Jochen Guck, has just passed away and yet I cannot believe it 🥹 Jochen is one of the most brilliant scientist I had ever met, a human being with unlimited qualities, brave and caring, positive (always) and full of ressources, helpful and with - always - the best advices.

New in @ScienceMagazine, we report that dilated cardiomyopathy can be alleviated by preventing hypocontractility-induced fibroblast expansion! The story is a fun combination of advanced in vivo and biomaterial-based in vitro models. Check it out! 📜 : doi.org/10.1126/scie...

Our new manuscript entitled "PhoCoil: A Photodegradable and Injectable Single-component Recombinant Protein Hydrogel for Minimally Invasive Delivery and Degradation" is now live at @ScienceAdvances! Check it out here (🔓): www.science.org/doi/10.1126/...

Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!

Stevens, A. J., Harris, A. R., Gerdts, J., Kim, K. H., Trentesaux, C., Ramirez, J. T., ... & Lim, W. A. (2023). Programming multicellular assembly with synthetic cell adhesion molecules. Nature, #EpithelialMechanics www.nature.com/articles/s41...

Tsai, T. Y. C., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C. P., & Megason, S. G. (2020). An adhesion code ensures robust pattern formation during tissue morphogenesis. Science, #EpithelialMechanics doi.org/10.1126/scie...

Nose, A., Nagafuchi, A., & Takeichi, M. (1988). Expressed recombinant cadherins mediate cell sorting in model systems. Cell, #EpithelialMechanics doi.org/10.1016/0092...

Steinberg, M. S. (1963). Reconstruction of tissues by dissociated cells: some morphogenetic tissue movements and the sorting out of embryonic cells may have a common explanation. Science, #EpithelialMechanics www.science.org/doi/10.1126/...

New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...

Congratulations to @stefanosala89.bsky.social , with help from @shreya-c.bsky.social al‬ on the optogenetic experiments, for the awesome story! Read the full preprint here: www.biorxiv.org/content/10.1... and thanks for listening!

Cell-cell contacts orchestrate tissue assembly and diverse cellular interactions. 🎯But what mediates their intricate patterns?🤔 Join me, @feyzanar.bsky.social, in exploring the interplay of adhesion and subcellular mechanics in contact patterning.

I'm thrilled to finally share my PhD work on understanding how Ca2+ signals regulate the protruding front of the cell. It’s been an incredible journey working alongside all the collaborators. www.biorxiv.org/content/10.1...

Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators! www.biorxiv.org/content/10.1...

I am excited to announce that in March, I will start my lab in the Department of Cancer Biology at the University of Pennsylvania Perelman School of Medicine @pennmedicine.bsky.social @penncancer.bsky.social stevens.bio

The latest from Lim Lab at CDI out today in Cell! "Synthetic organizer cells guide development via spatial and biochemical instructions" led by star postdocs Toshi Yamada and Coralie Trentesaux www.cell.com/cell/abstrac...