New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/ www.biorxiv.org/content/10.6...

👀 www.nature.com/articles/s41...

Wilt, Bam, Kobe sounds absolutely crazy.

Today we remember 𝗠𝗔𝗥𝗞 𝗥𝗢𝗧𝗛𝗞𝗢, who died on this day in 1970. 📸 Mark Rothko in his 53rd street studio, New York, 1954 by © Henry Elkan Artwork © 1998 by Kate Rothko Prizel and Christopher Rothko/ Artists Rights Society (ARS), New York

When I come to the Chase Center, I come to see the real goat.

Per fi hem resolt l’etern debat sobre l’ús del p-value en bioestadística. A partir d’ara, compararem la probabilitat d’un fenomen observat amb la de trobar un regal amagat al Bernabéu. Així afegim un nou graó en la construcció del Sistema Bernabéu Internacional, cridat a substituir el Sistema Mètric

A graphic haiku of science.

Bluetorial-Jim Watson I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions. What follows is my personal perspective. 1/41

I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...

This is basically at Mission Bay, UCSF campus. I still struggle to understand how we share the city with coyotes. It’s absolutely amazing.

Should I be worried?

I remember my first season on the job covering the Warriors, how many strangers would be up in my DMs asking “is (this person) playing tonight?” It was constant and annoying and the reason I linked the injury report in my bio.

Oh, so that wasn’t a nightmare? I can say I had my first earthquake in San Francisco, then.

Having the craziest weeks writing fellowships, doing experiments, and preparing for my first presentation in my new lab. I’m afraid what’s gonna look like the next day.

That’s a crime.

Happy to see that a Pedro can thrive.

🥲

In the minority here, but I think it would be refreshing and I'd appreciate reading a piece like "On the value of reductionist science". While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.

Paul George on està?

I was looking for our review, authored by Eileen, to share with a student and... AI decided to change our names to male names. Are women in science getting their names "translated" to Edward/Eduardo?

There's been SIX 20-point comeback wins this playoffs, the most in a single postseason in the play-by-play era (since 1997). Thunder: down 29 in G3 at MEM Pacers: down 20 in G5 vs MIL Knicks: down 20 in G1 at BOS Pacers: down 20 in G2 at CLE Knicks: down 20 in G2 at BOS Knicks: down 20 tonight

it's wild listening to old folks who entered academia in the 70s. full scholarships, grants to travel the world, robust humanities departments, tenure, pensions. they spend their peaceful twilight years in million dollar homes. while today's academics have no job security, career path, or savings

I’ve seen this story before. In the 2000s, Spain launched a flashy program to bring back Spanish researchers from abroad, mostly the US. Promises of funding, 5-year contracts with renewal into tenure-track, and investment. Then the 2008 crisis hit and, well, you can guess how that ended.

More infrastructure, long-term plans to raise science funding to 5% of GDP, more scientific jobs, stable funding year-round (not seasonal grant chaos), better salaries. Do that, and researchers will come. No need for flashy special programs.

I feel this is something no one talks about.

But eLife was moved to the preprint collection.

YES

OCD is a very real and debilitating disorder. A study of 50,000 people has isolated the genes involved, giving hope for more targeted treatments. www.abc.net.au/news/2025-05...

Social networks have brought many, many, maaaaaany bad things to this world. But one thing they got right: you can be 10000 km away from your friends and still feel them close, you can still support them and be supported.

Today is a good day to listen to this song youtu.be/7E9Ed9DUQoQ?...

The day the Chicago pope tries making pizza in the Vatican, 500 Italian YouTubers will start yelling “🤌🏽🤌🏽🤌🏽 ma’ che cazzo fai 🤌🏽🤌🏽🤌🏽”, while acting as if cooking a pizza as you want was a crime against humanity.

Mental Health Awareness Month: Institutions: Here’s a workshop on coping and resilience! Me: Cool cool… but when do I get decent pay and humane working conditions? #AcademicSky 🧪

A Chicago Pope implies the existence of an MLA Pope and APA Pope

A reminder.

I think you guys have no idea how hypocritical this guy is being. He’s been steadily defunding research and higher ed since he came into power and is about to cut 3 more billions from the budget next year. This is all posturing!

All this is exposing the reality of the European research system: built on underpaid, underfunded science. Until now, they could still say “well, we can’t compete with the US or China, but you should stay anyway, for the sake of people’s lives and the future of European science.”

Or remember to not eat meat.

I usually understand like 2% of what’s going on in these papers. But still, it blows my mind to think that someday we might be able to reprogram the hippocampus and actually retrieve lost memories in people with dementia.

Anyone posting on the major power outage in Spain/Portugal should also obligatorily note that, for those that still have power, it is renewables that are keeping them afloat.

I love these silicon valley bros that think ChatGPT has achieved some kind of sentience and therefore might have rights. Like dudes, you don't even think poor people deserve rights, let's try to achieve that before giving person-hood to the autocomplete algorithm.

On the anniversary of the sinking of the Titanic, we thought we'd answer a question that's often asked, "If they raised the Mary Rose, why not raise the Titanic?" Allow our scaled diagram to explain...

In this month's Technology Feature, @carolineseydel.bsky.social explores how researchers are using label-free microscopy techniques to study complex biological systems, from living creatures to peptides. www.nature.com/articles/s41...

One thing people tend to forget when debating the amyloid hypothesis is that, for years, Aβ was the only common thread among the many pathologies in Alzheimer’s. Now we have better data and a broader view? Great! But that doesn’t mean we should suddenly act like the amyloid hypothesis is fraudulent.

Does anyone in SF know why there are fireworks in the Mission district? Tonight one felt like a bomb. @missionlocal.org ?

👁️👄👁️

Every time I go into StackOverflow trying to fix a bug and end up reinstalling my OS because some guy speaking in binary says my environment is garbage. Just to realize later that it was just a typo.

One upside of things falling apart is that when we rebuild, we can fix past mistakes, like the ones we knew were there but were too afraid to face.

Hearing from a source: "A friend at NCI lost 3 outstanding staff (their words) and tweeted about it. She was suspended for 2 days. No idea how her tweet was flagged." This is for all the people asking us why it's hard to tell what's happening at NIH. Retaliation is real.