Our paper "Active-learning-guided optimization of cell-free systems for genome-wide transcriptomic profiling reveals progressive layers of regulation" is online in Nature Communications! Congrats Lea Wagner, very proud of this work! www.nature.com/articles/s41... #cellfree #AI #T7Phage #synbio

Targeted DNA insertion remains a major bottleneck in plant engineering. We developed an avian R2 retrotransposon as an efficient plant genome editor to precisely insert large DNA payloads at targeted sites: www.nature.com/articles/s41... Congratulations to @kimuchenje03.bsky.social and the team! 🧵👇

New preprint out 🌱 We present a new T-DNA vector system for Arabidopsis that supports clean, genomically mapped, single-copy T-DNA insertion with predictable cell-type/conditional gene expression. @mokhalil.bsky.social + Gehring labs biorxiv.org/content/10.6... 🧵1/16

5 days left now to apply for the postdoc opportunity in my lab at Imperial in London 🇬🇧 - there’s a chance that we can hire 2 people into the team on this synthetic biology and materials theme. Application link is here - www.imperial.ac.uk/jobs/search-...

Tunable and Orthogonal ECF and Anti-σ Threshold Gates for Temporal Control of Heterologous Gene Expression pubs.acs.org/doi/10.1021/... Impressive work from @georgfritz.bsky.social group at the University of Western Australia led by talented student Rebecca Wolters.

The Application deadline for the SynBio Hackathon has been EXTENDED until June 8, 2026! Apply Now Here: www.plantcellatlas.org/2026-synbio-... *Participants will be reimbursed up to $800 for travel and lodging costs.

📢Out now on bioRxiv: We used Plant STARR-seq to characterize the species- and condition-specific enhancer activity of over 350,000 sequences derived from four plant species. For more, see below and read the paper at: www.biorxiv.org/content/10.6...

A great place and working environment for Plant SynBio and Genome engineering!

Can CRISPR edits enable precise tuning of plant gene expression? We think: yes. In our newest manuscript, we measured the effects of >30,000 CRISPR-like promoter mutations in sorghum protoplasts.

🚨 Positions available in Plant Science! Please share. We’re hiring: 1. Postdoc 2.PhD (UK applicants only) Focus: root oxygen dynamics, developmental signalling. Come help us uncover how O2 shapes root development. More info here- sites.google.com/view/root-re... #plantscijobs #plantscience

Where is the #Arabidopsis community on @bsky.app? Any #Brassica fans? See our recent protocol covering design principles and considerations for building and testing programmable and reversible CRISPRi-based gene circuits in plants. 🧪 #plantscience @natprot.nature.com @ryanlister.bsky.social

ONE WEEK LEFT TO APPLY: We’re hiring 4 roles at UWA's Plant Synbio Innovation Centre: Facility Manager + 3 Postdocs (single-cell genomics/screening; molecular tools; construct prototyping) bit.ly/4qfoftG bit.ly/3MFgD59 bit.ly/4pFT6jf bit.ly/48VkgLw Apply by Tuesday 27 Jan 2026 (11:55pm AWST)

Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9

Big update: My the first Lloyd Lab conceived and conducted study has been accepted and published: Start Right to End Right: Authentic Open Reading Frame Selection Matters for Nonsense-Mediated Decay Target Identification www.mdpi.com/2073-4425/16... Now larger and better than the pre-print

I am delighted to share our latest work on memory gene circuits for plants. This work was led by the phenomenal PhD student @patrickgong.bsky.social A lot of debugging & highlights how even simple components in synthetic biology can have unexpected properties. www.biorxiv.org/content/10.1...

Just a few days left to apply! (closes Aug 25)

🎵 Every move you make, every telomere you shake, every strand you break, we’ll be watchin’ you...🎵 Advanced-imaging guru needed to keep a close eye on plant synthetic chromosomes in our ARIA research project at UWA in Perth & ‪@plants4space.bsky.social‬. Apply now: bit.ly/3GKSRSA

Happy to see our latest work out in @molbioevol.bsky.social. We revisit the evolution of 5-methylcytosine across neglected eukaryotic supergroups, establishing an ancestral repressive role silencing genome invaders, both transposons and viral elements👾: academic.oup.com/mbe/advance-... 🧵 1/7

We're hiring! Need a microscopy wizard to help build the world’s first synthetic plant chromosome! Bring your lights, lasers, & lens-craft to characterise new artificial chromosomes. Join our ARIA-funded project at UWA in Perth & ‪@plants4space.bsky.social‬. Apply: bit.ly/3GKSRSA

Come join us at UWA & @plants4space.bsky.social on the @aria-research.bsky.social funded project to build the first synthetic chromosome for plants! We are looking for specific expertise with microscopy to look at the synthetic chromosome we are building. external.jobs.uwa.edu.au/cw/en/job/52...

We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug. imperial.ac.uk/jobs/search-...

Recombinases your thing? In the latest from my lab, Veronica Greco shows how @nanopore sequencing + automated liquid handling provides the perfect platform for characterising these systems at scale! Awesome collaboration with @jennbrophy.bsky.social @sarah-guiziou.bsky.social doi.org/10.1101/2025...

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Non-model Bioeng Custom Lab Hardware Turn Key Genetic Design Please repost for reach 💚

#PlantScience Research Weekly: April 11, 2025. plantae.org/plant-scienc... 150 years of Arabidopsis genetics; Rewiring plant traits with synthetic circuits; Expansion microscopy in protoplasts and intact roots; Carbonic anhydrase mutation uncouples WUE and photosynthesis (1/2)

Programmable and reversible CRISPRi-based genetic circuits function in a variety of plants go.nature.com/4bpCNQa rdcu.be/egMmm

Thank you @aemonten.bsky.social ! This was the child of the great @adil-khan.bsky.social ! A huge effort of development and refinement

Engineering resistance with help from Liverworts, Mosses and Ferns @Phil_Carella @JohnInnesCentre www.jic.ac.uk/research-imp...

Our new review in @theplantjournal.bsky.social on synthetic gene circuits is out! I am super proud of this. I hope that it acts as a useful resource for people new to gene circuits. The switch-liker's guide to plant synthetic gene circuits onlinelibrary.wiley.com/doi/10.1111/...

If you're struggling to assemble large DNA constructs, check out Chengsong's DASH system, which combines Golden Gate cloning, recombineering, and site-specific recombinases to build multigene constructs of ~100kb. www.biorxiv.org/content/10.1...

Engineering a New Generation of Gene Editors: Integrating Synthetic Biology and AI Innovations pubs.acs.org/doi/10.1021/...

📜 Synthetic gene circuits in plants: recent advances and challenges 🧑‍🔬 @adil-khan.bsky.social, @ryanlister.bsky.social 📔 Quantitative Plant Biology 🔗 www.cambridge.org/core/product... #️⃣ #PlantScience #PlantSynBio #PlantSynthBio #SynBio

Happy to share our new review on plant synthetic circuits in Quantitative Plant Biology We explore the latest advances & challenges in the field. www.cambridge.org/core/journal... #synbio #plants

New review on plant synthetic gene circuits by their pioneer @adil-khan.bsky.social Synthetic gene circuits in plants: recent advances and challenges www.cambridge.org/core/journal...

AI-directed gene fusing prolongs the evolutionary half-life of synthetic gene circuits doi.org/10.1101/2025...

We’re looking for 3 postdocs to join our lab and work on engineering plant gene expression, metabolism and growth. If you have enthusiasm & skills in synthetic biology or metabolic engineering, apply by Jan 31. www.jobs.cam.ac.uk/job/49767/ www.jobs.cam.ac.uk/job/49773/ www.jobs.cam.ac.uk/job/49769/

🌱 Demirer Lab 🌱 @caltech.edu is looking for passionate graduate students to join us! Explore our exciting research for a sustainable future: demirerlab.com 🌏 🌱 🦠 📢 Apply here to CCE or BBE: t.co/cIv8Hbfy0Z and mention your interest in our lab in your statement. 🗓️ Application deadline: Dec 1

Mapping enhancer-gene regulatory interactions from single-cell data https://www.biorxiv.org/content/10.1101/2024.11.23.624931v1

Deep generative design of RNA aptamers using structural predictions doi.org/10.1038/s435...

I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3 experiment.com/programs/pla...

Let's get this started with some recent #synbio papers. Starting off with one I was the editor for: Control of spatio-temporal patterning via cell growth in a multicellular synthetic gene circuit www.nature.com/articles/s41...