They say the sincerest form of flattery is mimicry, and we really love histidine! ❤️ Check out our most recent work on histidine mimics: Genetic incorporation of diverse non-canonical amino acids for histidine substitution. www.biorxiv.org/content/10.1...

We are hiring! Excited about redox chemical biology? Help us discover what controls the redox state of the Golgi apparatus. Also, please help us spread the word by reposting this ad. Apply here: jobs.uzh.ch/job-vacancie...

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

Congratulations to Doro for another presentation prize! This time for her talk at SCF ChemBio in Paris.

The @locbp.bsky.social @chem.uzh.ch developed a gene expression reporter system based on the coexpression of the protein of interest BiP/GRP78 and the reporter HaloTag. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Congratulations to Hen (again)! Her paper, in collaboration with Jade, Juan, and the EPFL ACCESS team was just published. The paper describes a chemigenetic gene reporter tool for time-stamping and pulse-chase-type experiments. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Congratulation's to Hen! Great job presenting her chemigenetic gene expression reporter system!

Congrats to Juan! His discovery of hemicyanines as potent activators of paraptotic cell death has just been published! With great contributions from Jade (initial observations of ER swelling) and Craig (crucial supporting experiments)! pubs.acs.org/doi/10.1021/...

Happy to share the results of a fun side project in which we used the COUPY dye and mutants of HaloTag7 to show that changes in fluorescence lifetime correlate with the polarity of the protein binding pocket! chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... #FLIM #fluorescence #HaloTag

🚨Open PhD positions in chemical biology!🚨 Join us in developing chemigenetic probes for imaging and sensing. ⚗️🧫Experience in chemical synthesis and/or protein engineering? 🗻🇨🇭Love mountains, chocolate, and a safe, diverse, and engaging environment? Apply (or re-post)! jobs.uzh.ch/job-vacancie...

🚨 PhD Opportunity! Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student! 🔬 Exciting interdisciplinary research 🤝 Engaging environment 🌱 📄 Does this sound like you, apply now! ⏳🔗 📢 Know someone? Share this! 🔄 jobs.uzh.ch/job-vacancie...

Looking for a PhD candidate to join my group at the University of Zurich If you are an excellent and motivated student🧑‍🔬and want to integrate organic synthesis, photochemistry and redox chemistry in a research🧪 we want to know more about you! More info: www.stacko.group Appreciate sharing the post.

Now online at a peer-reviewed journal, Carla's careful characterization of the redox state of glutathione in the Golgi apparatus: www.sciencedirect.com/science/arti...

Exciting news from the lab! Our first preprint, “Hydrophobic Tuning with Non-Canonical Amino Acids in a Copper Metalloenzyme” is now available. In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary. 🔍: www.biorxiv.org/content/10.1...

Congratulations to @puentene.bsky.social, who won the best poster award at #SMPS24 @smps4.bsky.social!!

Another brilliant session by Pablo Rivera-Fuentes from the University of Zurich on 'Single-Molecule Protein Identification using Blinking Patterns.' #SMPS4

Just out on bioRxiv, Carla Miró reports the first quantitative determination of the redox state of glutathione in the Golgi apparatus. Spoiler alert: it is very oxidized and in relatively low concentrations! www.biorxiv.org/content/10.1...

Long overdue, we have left the propaganda machine formerly known as Twitter and will be posting exclusively here!