The Metagraph paper is out in Nature; it showed up in my feeds today! Congratulations to Mikhail Karasikov, @gxxxr.bsky.social, @akkah21.bsky.social and all of the other authors (whom I'd love to follow on Bluesky if I can find you ;P) www.nature.com/articles/s41...

Have you recently completed (or finishing soon) a PhD in CS or a related discipline? Do you want to do research advancing the theory & practice of algorithmic genomics & build tools that people love to use? I'll be looking to hire a postdoc! Official ad coming soon: docs.google.com/document/d/1...

Another amazing opportunity at UMD in Mihai Pop's lab! Mihai is looking for a bioinformatics software engineer. Consider applying here if you're interested: umd.wd1.myworkdayjobs.com/en-US/UMCP/j...

A new paper from the lab! Work led by @drtamermansour.bsky.social and others not here on bsky. "We propose the Great Genotyper, a population-scale genotyping workflow to address the N+1 problem."

O trabalho morto do processamento exige trabalho vivo do cientista para ser tornado útil. Mas ninguém está nem aí pra utilidade, isso aqui é capitalismo. O objetivo é dinheiro. Bem, 16 anos atrás, o capitalismo inventou uma forma 'exótica' de transformar processamento em dinheiro: criptomoedas.+

Existe uma história da escalada do processamento de dados global que é muito pouco contada. Vai ser um fio longo, espero que interessem a vocês. Em 1965, Gordon Moore, co-fundador da Intel, prevê que a capacidade de processamento /custo dobra a cada ano. Ele previu que isso duraria 10 anos.+

E o nocivo e cretino empresariado brasileiro já se movimenta pra fuder o trabalhador por pura birra com a isenção de IR pra quem ganha até 5 mil. Não há custo adicional algum - conforme a própria matéria destaca. É só ódio e nojo de pobre mesmo. melhorrh.com.br/isencao-ir-5...

#RECOMB2026 is now accepting submissions and we'd love to see your best work! 📌 Abstract registration: Nov 7, 2025 📌 Full paper submission: Nov 14, 2025 📜 More info: recomb.org/recomb2026/call_for_papers.html

Normative framework of bigger tech (aka, me trolling the tech audience)

Looking for people to test the latest version of simd-sketch. It's now 2x as fast at sketching, and supports skipping over kmers containing N and other ambiguous bases (which is only ~35% slower). 'cargo install simd-sketch' is right there under your fingertips ;) github.com/RagnarGrootK...

the youtube vs yt-dlp arms race is hilarious, because of how lopsided it is. on the one hand, you've got a company with the GDP of Denmark who has about a manhattan-project's worth of developers they can assign to this. but on the other end, you've got every bored or annoyed javascript hacker.

Hoje o podcast Dragões de Garagem completa 13 anos no ar! Ao longo desses anos a mídia podcast teve vários momentos, mas acreditamos que a essência permanece: trazer conteúdos sobre ciência de forma responsável. +

«Python Fluente» à venda no Catarse agora! www.catarse.me/pythonfluente Volume 1 por R$ 99+frete, ou os 3 volumes, em 2 opções de acabamento (brochura P&B, espiral cor). Também: kits com xilogravura do calango da capa, assinada e numerada pelo artista Thiago Castor. 👉 Nas lojas será mais caro!

a cultura paulistana é anúncio publicitário, ir visitar o café-anúncio, a exposição-anúncio, assistir o filme-anúncio, ir no teatro-anúncio, pagar pra ir no parque-anúncio, tirar foto na frente do anúncio

No fim da thread a revelação que é simplesmente o CONSERVATÓRIO DE TATUÍ, uma das maiores instituições de música do país. O Tarcísio quer destruir uma das coisas mais legais que o estado tem

3/ Tech fascism in a nutshell: “Computers are so much more rule-based, controllable, fixable, and comprehensible than any human will ever be. As many political schools of thought do, these technolibertarians make a philosophy out of a personality defect.“ She wrote this in 2000!

1/ A longtime Wired editor just wrote a mush-brained essay about how he totally missed the political rot of Silicon Valley (& still doesn't get it). But in the late 1990s, a Wired journalist warned of a toxic ideology bubbling up from tech. Paulina Borsook has largely been erased. Let's change that

I think there could be an EU tech sovereignty that isn’t just three SAPs in a trench coat but uhhhh

O livro “Tecnologia Sem Teto: por territórios digitais soberanos” nasce das lutas do @mtstbr.bsky.social e mostra como a tecnologia pode ser reinventada pelo povo, como ferramenta de emancipação e não de opressão. 👉 Garanta o seu na pré-venda: www.nucleodetecnologia.com.br/livro

Please stop using OpenTorment!!! It's only open-core! TormentLibre is the fully FOSS alternative!

Excited to share our EvANI benchmarking workflow, published in Briefings in Bioinformatics doi.org/10.1093/bib/... Computing average nucleotide identity (ANI) is neither conceptually nor computationally trivial. Its definition has evolved over years, with different meanings and assumptions (1/5)

MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n 📄 www.nature.com/articles/s41... 💿 mmseqs.com

#rustbio 3.0 is released, providing BEDPE support and an improved API for Myers bitparallel pattern matching. github.com/rust-bio/rus...

Seriously that text goes so hard, I love it: "[My new license] is not following the OSI definition of open-source because i don’t give a damn how capital defines its needs."

Pixi Global is known as a tool to manage CLI applications, but did you know that you can also install shell completions and even graphical user interfaces with it? Learn more by reading Lucas' and Julian's blog post: prefix.dev/blog/using-...

Have you ever looked at some differentially occurring gene clusters in a microbial #pangenome and thought to yourself "I wonder if they contribute to any metabolic modules"? With the most recent changes, the answer is a few clicks away in #anvio 😇

Da semana passada lá no catarse do ryotiras APOIE > www.catarse.me/ryotiras #humor #quadrinhos #ryotiras #ryot #tirinhas #tirinha #tiras

Published a new version of parquet-wasm: github.com/kylebarron/p... - Update to latest version of Rust parquet crate - Workaround to read Parquet data containing Arrow string view/binary view types - Streaming writes - Comparison between parquet-wasm and hyparquet, a pure-JavaScript Parquet reader

The EMBL PhD programme is open until 13th October (entry ~Sep 2026): www.embl.org/about/info/e... We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them

A huge shoutout to the Zefiro (iyky) and every other ship and crew in the Sumud Flotilla: globalsumudflotilla.org/tracker/ There is so much going on right now, but this is what matters. Putting bodies in place for justice. By land, by sea, until everyone is free.

Blogged about how zstd --long fills the gap between fast and slow-but-high-ratio genome compression methods log.bede.im/2025/09/12/z...

Discovering computer as an adult makes you go crazy. Discovering computer as a baby makes you go crazy. In all of human history, there will only ever be one generation to discover computer at the correct age: 13

Quantas vezes ouvimos "não vai dar em nada". Mas deu. E hoje o Brasil dá um exemplo pro mundo (e pra si mesmo). Essa é pra todo mundo que chorou a perda de entes queridos enquanto esse verme imitava eles morrendo.

Militares sendo condenados por tentativa de golpe num país da América Latina. Não é pouca coisa. E no dia em que lembramos do golpe militar patrocinado pelos EUA no Chile. Simbólico.

PODE JÁ!!

"A bruxaria é o recurso dos despossuídos, dos impotentes, dos famintos e dos abusados. Ela dá coração e língua a pedras e árvores. Ela veste a pele áspera dos animais. Ela se volta contra uma civilização que sabe o preço de tudo, mas não sabe o valor de nada." — Peter Grey, Bruxaria Apocalíptica

I sincerely appreciate the opportunity to visit @ebi.embl.org (thanks to the @embl.org Sabbatical fellowship). The guidance and support I received from Zam (@zaminiqbal.bsky.social), John (@bacpop.org) and other colleagues have been immensely valuable! You changed my career！❤️

Sometimes you meet absolutely incredible bioinfo-magicians. It was a huge privilege when @shenwei356.bsky.social joined our group for a year on an @embl.org sabbatical. While here, he developed a new way of aligning to millions of bacteria, called LexicMap 1/n www.nature.com/articles/s41...

It has never mattered how thin a computer is.

Zstandard's --long range mode works wonders for assemblies, but needs uninterrupted single line sequences. *AllTheBacteria 661k, multiline fasta* gzip (pigz): 751GB zstandard --long: 641GB (30% original size) *Single line fasta* gzip (pigz): 700GB zstandard --long: 232GB (10% original size)

There are two recent papers that use sourmash in creative ways - and it gladdens my heart! pubmed.ncbi.nlm.nih.gov/40812187/ by @silask.bsky.social et al looks cleverly at human gut subspecies. www.biorxiv.org/content/10.1... by @rayanchikhi.bsky.social et al counts billions of k-mers. Super neat!

Preprint out for myloasm, our new nanopore / HiFi metagenome assembler! Nanopore's getting accurate, but 1. Can this lead to better metagenome assemblies? 2. How, algorithmically, to leverage them? with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social 1 / N

For anyone who has used pling for comparing plasmids using rearrangement distances ("how many structural events apart are these plasmids"), here's how to tweak parameters, and integrate it with typing info, and the host phylogeny www.biorxiv.org/content/10.1... github.com/iqbal-lab-or...

ME, IN TEARS: you can't just say every single part of a computer system is a file UNIX, POINTING AT THE MOUSE: file

Great. I am doing my part here in Brazil. This Wednesday I am doing a livestream with @emilymbender.bsky.social and @alexhanna.bsky.social www.youtube.com/live/qP-hG53...

Desenvolvimento de alta tecnologia pode não ser a primeira coisa que vem à mente de muitos ao pensar em Cuba. Mas essa pequena ilha, mesmo com recursos e acesso ao comércio internacional muito limitados, desenvolveu vacinas contra Covid-19 e câncer de pulmão. Como? É o que quero falar nesse fio.

A BLAST update adding support for compressed files and csv output with headers is a Good Friday night surprise! blast.ncbi.nlm.nih.gov/doc/blast-ne...