📝 Online now - the Review "Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier" from Edmund Kunji (@mrc-mbu.bsky.social) and co. #SLC54 #MPC #EnergyMetabolism #MembraneProteinStructure #StructureBasedDrugDesign Read it here 👉 authors.elsevier.com/sd/article/S...

Congratulations to @lucialugut.bsky.social who passed her PhD with flying colours last week; and with no thesis corrections ☺️🎓👏

Bluesky, I am pleased to present to you the main product of postdoc work, published in @science.org ☝️ As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm

Congratulations!

Congratulations to Abigail Giles who was awarded the "The Richard J. Bing Award for Young Investigators" at the recent World Congress of the International Society For Heart Research in Japan. Well done Abigail!

Trinity Hall covers our discovery www.trinhall.cam.ac.uk/news/unwrapp... Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...

P-hacking Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science. www.nature.com/articles/d41...

Throwing a ‘spanner in the works’ of our cells’ machinery could help fight cancer, fatty liver disease… and hair loss | EurekAlert! www.eurekalert.org/news-release...

Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social @mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA www.embopress.org/doi/full/10....

Well done everyone! 😎

Mitochondria differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions. www.nature.com/articles/d41...

Shared first authorship, but who gets to be first? According to this study, there is no disadvantage to sharing credit. Weakness of the study: The test name was a gender-neutral European name. Can someone please repeat this study with female/non-European names? www.nature.com/articles/d41...

@mrc-mbu.bsky.social all set to entertain the public @cambridgefestival.bsky.social Come and join us at CAST, Cambridge, and learn about our amazing work to understand all things #mitochondria in health and disease

Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner www.embopress.org/doi/full/10....

Glad to be a small part on this interesting paper from Milos Filipovic with actual work done by Jan Miljkovic and Alva Casey in my lab. Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation: Cell Metabolism www.cell.com/cell-metabol...

First of two videos I made about vaccines for kids & teens! YouTube promotes videos with engagement, so likes/comments/shares help reach the right audience. Even if you're not the target, your support matters! 💙 Watch & boost? 🔗 youtu.be/KC42D0ZpqtE #SciComm #Vaccines #ScienceForEveryone

Second of two videos I made about vaccines for kids & teens! YouTube promotes videos with engagement, so likes/comments/shares help reach the right audience. Even if you're not the target, your support matters! 💙 Watch & boost? 🔗 youtu.be/ScOQ2tt5HQQ #SciComm #Vaccines #ScienceForEveryone

Simple science videos for kids and teens. Although you are not the primary target, you can help by liking and subscribing to help these videos reach more kids! Let’s make science fun and easy for everyone!

📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n www.biorxiv.org/content/10.1...

Updated list. As more and more people join bluesky, I want to share this link again. Also, it's difficult to find everyone, so react to this message if you're a (former or current) MBU member and you're not in the list yet. go.bsky.app/9ATZngh

I asked chatGPT to make a video: A 2-minute YouTube video for teenagers explaining what mitochondria are, what they do and why they are special (e.g. own DNA, inherited from mother, bacterial origin). Here is the result: www.nextgenseqanalysis.com/videos-1/v/m... What do you think?

Are postdocs the overlooked backbone of academia? Despite their vital contributions, postdoctoral researchers are often stuck in precarious, temporary roles with limited stability or recognition. www.linkedin.com/posts/lindse...

From a young age, boys are praised for speaking up, girls for staying quiet. Boys believe their views matter more. Girls learn to smile, work quietly, defer to boys, and speak only when asked. No wonder many girls lose their voice, confidence, and ambition. www.theguardian.com/commentisfre...

Can you explain your doctoral research through interpretive dance? The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: scim.ag/3BcKi0e

Whether you’re a postdoctoral researcher dreaming of independent research or a seasoned researcher plotting your next move, the tips in this article will strengthen your candidacy. www.nature.com/articles/d41...

Research shows the heavy toll PhD studies take on mental health, with a 40% rise in psychiatric medication by the fifth year. It's time to address the pressure on doctoral students and prioritise their well-being. #PhD,#MentalHealth www.nature.com/articles/d41...

Hello, world! We are the MRC MBU Postdoctoral Society, and we are very excited to be here! 👩‍🔬👨‍🔬🧪