happy 9th anniversary to the day we watched Zendaya fall madly in love with Tom Holland in real-time

😱 Super excited to be named as a Guggenheim Fellow!! 😱

I can't stop laughing at this post. It's perfect.

On NOFOs and funding. grants.nih.gov/news-events/...

It has gone under the radar, but the University of Minnesota has selected a new brand tagline: "Leave a Future" Ummm ... it kind of makes the old "Driven to Discover" tagline look like a work of genius. I've got another tagline to run by them: "Uff da" umarcomm.umn.edu/brand

We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4 Preprint: www.biorxiv.org/content/10.6... Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore

Today, Minneapolis had their annual Powderhorn Art Sled Rally. A community organized event that this time featured de-Icer sleds and bowling pins named for world leaders. A very Minnesotan way to protest ICE. 😍🙌🏻

The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024. Learn more:

Nice containerization of AlphaFold, Boltz, and Chai, and calculation of metrics (including our ipSAE score for protein-protein interactions). www.biorxiv.org/content/10.1...

Well, this is a huge Executive Order power grab... www.whitehouse.gov/presidential... 1/3

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

Russell Vought wanted to shut down all extramural grants from NIH in this current fiscal year, putting stop to ALL research across the US. Someone in the White House had better sense. But Vought is a dangerous man, who will stop at nothing to destroy science in America. www.wsj.com/politics/pol...

This NIH grant Multi-Year Funding ploy really makes you wonder what equally obscure and equally harmful stuff Vought is advancing across all the other functions of federal government, doesn’t it?

This is just so screwed up.

Researchers’ chances of winning a grant from the National Institutes of Health have dropped under a new policy. scim.ag/4f7uew2

This 4th percentile funding cutoff for the NCI is so very catastrophic. Assuming a 4th percentile payline corresponds to a ~5% success rate, it would take 27 grant submissions to have an 80% chance of getting just one funded. At the current submission cap of 6 apps as PI/year that means 4.5 years

NIH staff are being required to fully fund ~ 50% of their grants. This means that all 4 years of an award will be paid out of this appropriation. This will help them get the appropriated funds spent, but will mean they can only fund (1/2 + 1/4*1/2) = 5/8 has many grants as they would have otherwise.

Multi-year funding at NIH: The Quickening drugmonkey.wordpress.com/2025/07/23/m...

"NIH has ..implemented a new policy requiring that at least one-half of the remaining funds for competing research project grants (RPGs) in FY 2025 be used to upfront fund RPG competing awards. Upfront funding provides the funding for all years of the approved project period .. from one fiscal year"

Talk about your grant lotteries. Earn a 4%ile for a chance at a four year award....or bupkis. whee.

There is a rally on MONDAY at 4:30 PM to stand up for NIH. Please join. Many NIH employees signed the Bethesda Declaration, objecting to the destruction of NIH. The Trump NIH Director asked the signers to meet. The rally follows that meeting, in support. actionnetwork.org/ev...

Had such a good time at aps2025.org, so good to see everyone! A real community.

I started reading DrugMonkey when I was NIGMS Director. I will impressed with his command of NIH policies and practices and his clear, direct voice to scientists and to NIH. We started the NIGMS Feedback Loop blog (the first IC director-written blog) in large parts because of his example. 1/n

Drugmonkey is one of the people who helped me feel not alone when I was starting out. NIH funding is a tough game (even tougher now?) but it’s normal for it to feel hard!

This is the way we recommend everyone make targeted proteomics assays. We've been doing it this way for 6-7 years now but only recently got around to putting a manuscript together. We use it for everything from SRM to PRM. Great work by @deannaplubell.bsky.social

👇🏼👇🏼👇🏼

The NIH firings, and the grant cuts that pushed out scientists at universities, have already had DEVASTATING effects on US science. Research labs are precious and fragile things. Taking one key person out can break it. ICYMI, we pub’d an essay on this: altnih4science.subst...

UPDATE: The NIH has made this move official — publishing the draft we reported on this morning www.statnews.com/2025/04/21/t...

“Instead of cutting red tape, they are strangling grantees with it,”

This guy is doing his best

It was pretty crowded on the capitol lawn today!

“a 400-year-old institution should be making decisions with a time horizon of centuries, not news cycles. Making a principled stand now…is the single best thing Harvard could do to earn its continued place as a symbol of genuine excellence” www.bostonglobe.com/2025/04/04/o...

I know I'm biased because it's my team but this video is very very funny

Well I'm crying now

My R35 application’s Commons page now says Council meeting will be May 22nd. 🤞🏼🤷🏼‍♀️

1. For the past thirty years I've had the best job in the world. 
I've had the opportunity to follow my curiosity; explore the workings of nature and society; mentor students and junior colleagues in the same process; and teach generations of students about it all.

What it's like inside the NIH under current conditions: not good. Terrible uncertainty and low morale, and an inability to order even basic materials because of trouble with the purchasing department:

Here's a super helpful site called Signal in the Storm that is automated to keep track of federal policy changes (EO's and Ed dept) and news re: academia. Also includes suggestions on what to do, and a faq's page about indirects, etc. Pls RT! signalinthestorm.org/index.html

"Not only is silence in the face of mounting authoritarianism morally objectionable, but, as the Columbia case suggests, it’s not working" www.thecrimson.com/article/2025...

@smith.senate.gov @amyklobuchar.com We need your help!

2025 Quantitative Proteomics Course in Seattle WA. Space is limited, register now! This is the 11th year of offering this weeklong course. skyline.ms/project/home... #proteomicsky #massspecsky #massspec

Academia’s often misguided view is that resilience is the ability to adapt and overcome challenges or adversity, but such an attitude can mask a toxic lab culture, say some researchers. https://go.nature.com/4kv5ro4

Hi. I am trying to understand what is going on with the changes in the NIH Clinical Center. If anyone has anything that they think might be useful, DM me or (better) find me on Signal (jeremymberg.78)

Hi. I am trying to understand what is going on with the changes in NIH review. If anyone has anything that they think might be useful, DM me or (better) find me on Signal (jeremymberg.78)

I’m not as freaked out about this as I am about all the other things going on at NIH. The part that sucks is the loss of jobs for IC review coordination staff. But CSR already has reviewed most grants and led the way on how ICs do peer review. Any other year I don’t think this would sound scary.

The reason Gen X doesn't trust anyone