🥳 We’re #hiring! 🎉 🎉 🎉 tiilab.org #Computational #postdoc scholar position open - focusing on leveraging #singlecell, #spatial, #imaging, and #AI to uncover mechanisms and therapeutic targets on overcoming resistance to #immunotherapy. Position is hybrid. DM or Email baor AT upmc DOT edu w CV :)

The UK's Medicine & Healthcare products Regulatory Agency (MHRA) became the 1st regulator globally to approve the new oral women's health drug by Bayer (originally through KaNDy Therapeutics acquisition) #biosky

Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer | New England Journal of Medicine nejm.org/doi/abs/10.105…

Great new work from #TRACERx team: Subclonal immune evasion in non-small cell lung cancer! First study ex vivo #NSCLC demonstrating #PDOs are an excellent technology on #subclonal tumor evolution affecting #immuneescape. t.co/1YUzihcY2H #nonanimal #alternative #methods #cancer #immunotherapy

A high proportion of CD38 (high) CD16 (low) NK cells in tumor patients can interrupt immune surveillance and favor tumor growth link.springer.com/article/10.1...

New Journal for ImmunoTherapy of Cancer article: Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma bit.ly/4lcxHLC ‪ @riyuesunnybao.bsky.social @pancpathologist.bsky.social ‪ @zervanto.bsky.social @jasonlukemd.bsky.social #JITC #cancer #MedSky

🚀First time joining #ENAR2025 and ✨Grateful to share our lab's work leveraging #singlecell #spatial #pathomics #radiomics to understand resistance/response in #cancer #immunotherapy. Had a wonderful time discussing #statistics & #quantitative sciences for #biological #clinical impact w my peers!!

Looking forward to #ENAR2025!! I will be discussing our lab's new work in using #singlecell omics and #radiomics to understand resistance and response in patients who received #immunotherapy. Here we come - #music, #food, and GREAT #science 🚀💃 @enar-ibs.bsky.social

We have a #research tech job open 🤩 if you are interested in quickly gaining experience in #translational & #clinical space, DM /send me your CV. #master #graduates who want to go to #PhD or #MD prog w strong motivation + #wetlab exp are welcome to apply!! #standupForScience #standupAgainstCancer

Where are the #AI #Agents who can clean up/reformat all publication #figures and #deposit big data cuz I would like to buy one Would even better if AI Agents take care of all the #paperwork and #administrative tasks so that I, a #human, can focus on #science and #curing human diseases

Back to #Nak #Won Garden and loving it!!! The best #authentic #korean food in the Burgh. Plus Friendly environment and super nice owners 😍

Human-relevant neuroscience research is everywhere, but so many many poorly translatable experiments on animals still get funded. Why? One reason: Grant reviewers are mostly animal experimenters themselves. New preprint from @katherineroe.bsky.social & me 🧵 🧪 www.biorxiv.org/content/10.1...

Respect 🫡

#NIH websites were down with wide spread intermediate #access issues . Have never seen this before

#flow cytometry experts, which #R or #Python packages do you use to analyze 30+ color #spectral flow data? cyCONDOR? cytofkit2? Other recommendations? Thanks!!

Here is a growing list of #universities and #programs that have to reduce or pause graduate admission as a consequence of indirect cuts, and funding freeze. We are witnessing an entire generational loss of #science.

Great #science, #food, and #ski tracks! Plus, it’s snowing 😎🔥⛷️ #TRCCC2025 #cancer #immunotherapy

Dr Rose Doerfler from our lab #ImmunoTiil presenting her work in #headNeck #cancer patient derived #organoids #TRCCC2025. Looking forward to further developing this scalable ex vivo technology for rapid #oncology #immunooncology #therapeutic #HNSCC!!! Check Rose poster #62 tonight to learn more!

Dr Alan Hutson, Chair of Biostats and Bioinfo Dept #RoswellPark Cancer center giving keynote #immunoOncology translational network #IOTNmoonshot at #TRCCC2025 annual meeting !!! 🚀Especially important for today’s scientific landscape

#Glioblastoma #Cortical #Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer #precisionOncology #PDO scRNAseq revealing endogenous #malignant #transcripts transfer #EV from malignant to nonmalignant cells, toward #GBM cell states + #astroglia cell types! tinyurl.com/5h2v8tak

Has it occur to anybody that a non-profit initiative should be put together to #backup all #US #government funded #data #repositories, such as GEO, SRA, GDC, among many others? It could be just all gov funded resources is gone overnight?! Not saying it is happening, but it could.

At these bleak times when the intent seems to be to cripple NIH-funded research, a reminder that NIH funding sustains the economy and creates jobs “In fiscal year 2023, NIH funding generated an estimated $92.89 billion in economic activity.” www.nih.gov/about-nih/wh...

#pathology #AI twitter - recommendations on a reliable predictor of #HPV status directly from #HE images in #HNSCC, that has been validated in large datasets across sites #opensource? We could build our own models but do not wish to reinvent the wheel if great tools already exists. Thank you !!

🚀 Exciting news! The brand-new #Y2025 #SITC #CompIO Webinar Series is here!!! 🎉 Ten courses focusing on advanced methods and clinical utility for #biomarker #development in IO @sitcancer.bsky.social @roswellpark.bsky.social #NCI 👏 ✨ FREE registration: tinyurl.com/3863jp9t Let's spread the word!🚀

An update with latest data available for graph of life expectancy vs health care expenditures per capita for 20 countries and one outlier.

An integrated transcriptomic cell #atlas of #human #neural #organoids: 36 #singlecell #transcriptomic datasets spanning 26 protocols, totalling 1.7+ million cells. www.nature.com/articles/s41... Interactive portal: archmap.bio#/ Great resource for all researchers in this field!!

Convergence of evolving #AI and #ML techniques: #multiomic, #spatial imaging, #pathology, #radiomic technologies enable a deeper understanding of #tumor #biology & #precision #oncology, such as building virtual #digitaltwins to optimize trial design. www.nature.com/articles/s41...

After battling the impossible parking in lawrenceville 🥷 we had a delicious meal at #Tram’s kitchen #split #rice 🤤 and made to #sungazer concert @ #thunderbird cafe & music hall ☀️ 🎷🎸🥁 which we had missed , for the past three times when they came to #Pittsburgh 🥹

#Artificialintelligence-based #biomarkers for treatment decisions in #oncology: #radiology #pathology #omics #EHR #LLM clinical implementation requires validation, prospective trials, medicoeconomic eval while extending #personalized #medicine to a broader population. www.cell.com/trends/cance...

Pluripotent #stemcell-derived #therapies in #clinical #trial: A 2025 update - a timely review on 115 clinical trials testing 83 #hPSCs products, majority targeting #eye #CNS, and #cancer! www.cell.com/cell-stem-ce...

Happy #LunarNewYear 2025!! 祝大家蛇年吉祥，好运连连，万事顺遂，阖家幸福！

Rapid and scalable #personalized antisense oligonucleotides #ASOs screening in #patient-derived #organoids - Preclinical evaluation of personalized ASO #therapeutics for a broad range of #rare #diseases!! www.nature.com/articles/s41...

#NAS released announcement on "Resources for Researchers and Scholars under Threat in the United States " tinyurl.com/3kvmc8vv

#Organoid #Community ✨ What cool technologies/strategies have you used to scale up your #PDO expts? 🧫🚀 #academic #labs We’re spending lots time expanding individual cases, tons of pipetting and limited wells per plate. This is prior to drug screening (which is automated by robots). 🙏 Thanks!!

Integrating #clinical, #pathological, #radiological, #transcriptomic data boosts prediction of #firstline #immunotherapy outcomes in metastatic #NSCLC 🚀 ✨317 patients, PET/CT, bulk RNAseq, digitized pathology => #Multimodal #AI outperform traditional methods! t.co/MfMNwuZaG9

Did you see this experiment my colleague Kristina conducted not just at my university but *in my department*? She and the male instructor assumed eachothers’ names for an online course: and the difference in feedback they received was horrifying.

Highly recommend (long) read for anyone who's been leading a lab 10+ years!

Happy #Thanksgiving2024 !!! 😆 We decided to get #Costco #chicken for dinner. NOT BAD

💫 Excited for our monthly #NCI #Computational #Oncology Working Group #COWG @ #RoswellParkCCC & #CIMAC-#CIDC!! Today we welcome 🌟 Dr. Xianlu (Laura) Peng #UNC_Lineberger to share work decoding #pancreatic cancer #heterogeneity, a aggressive, therapy-resistant cancer🔥!!!#CancerResearch #DataScience

🚀#SITC2023 is around the corner! Looking to take the next leap in your career #computational #immunoOncology #immunotherapy? Let's set up a time to chat!! We're hiring. From #tenure to #nontenure track faculty, and #staffscientists @UPMCHillmanCC #datasciences !! Please RT. Thank you ☺️