Jason Luke, MD, FACP, FASCO
@jasonlukemd.bsky.social
๐ค 269
๐ฅ 177
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Physician-Scientist-Executive; Chief Medical Officer
Appreciate the profile
www.statnews.com/pharmalot/20...
from Ed Silverman &
@statnews.com
! Amazing progress at Strand Therapeutics advancing field leading genetic medicines. Check my quote on being a nutating mixer if I were a piece of lab equipment ;)
#synbio
#immunotherapy
#cancerresearch
23 days ago
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reposted by
Jason Luke, MD, FACP, FASCO
Nature
2 months ago
Nature research paper: Humoral determinants of checkpoint immunotherapy
go.nature.com/41a8fin
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Humoral determinants of checkpoint immunotherapy - Nature
Rapid extracellular antibody profiling reveals a contribution of autoantibodies to the effectiveness of checkpoint immunotherapy for cancer.
https://go.nature.com/41a8fin
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Podcast alert! Enjoyed discussing
#ASCO25
#Immunotherapy
&
#Melanoma
data w Dr. Diwakar Davar. Important studies that are advancing the field!
@ascocancer.bsky.social
dailynews.ascopubs.org/do/podcast-i...
3 months ago
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The CheckPoints are ready to party - join us tonight Sunday June 1 at Buddy Guys! Best party of
#ASCO25
& all for the great cause of the
@sitcancer.bsky.social
Forward Fund that supports post-doc & trainee awards. See you tonight!!!
4 months ago
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Time for the
#AACR25
Annual Reception, featuring the
#Checkpoints
! Be there tonight 830 PM at McCormick Place West (Level 3) in the Skyline Ballroom (W375). We have a bunch of new tunes & rehearsal was great!
@theaacr.bsky.social
5 months ago
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Excited to help lead Phase 2/3 frontline metastatic
#melanoma
TeLuRide-006 study of pembro +/- novel IV TLR7/8 agonist EIK1001. Super interesting pre-clinical & prelim responses in PD1 refractory dz. Trial is open in
#Pittsburgh
& globally for accrual!
clinicaltrials.gov/study/NCT066...
6 months ago
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reposted by
Jason Luke, MD, FACP, FASCO
Society for Immunotherapy of Cancer
6 months ago
VIP tickets are available now! The CheckPoints will be back in Chicago on June 1 at Buddy Guyโs Legends. Donations will support SITCโs Forward Fund and benefit the next generation of cancer immunotherapy experts. LEARN MORE:
www.sitcancer.org/funding/the-...
#RockinForACure
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Talking IMA203 & SUPRAME trial
#iwCART25
in Miami last wknd. Pass the word to
#melanoma
patients needing novel therapeutics. After ICI, this therapy has possibility for long-term dz control! Trial opening in USA & Europe. 1st pt got IMA203 in Pittsburgh last week!
clinicaltrials.gov/study/NCT067...
6 months ago
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Extremely excited re: IMA203 - PRAME TCR T cells Ph 1 study published in
@natmedicine.bsky.social
! This is a transformative Rx in
#melanoma
for HLA-A201+ & PD1 refractory pts. Compared to TIL, easier to make, less toxic & so far ~2x response rate in heavily pre-Rx.
www.nature.com/articles/s41...
6 months ago
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A
@sitcancer.bsky.social
vision statement on accelerating
#clinicaltrials
to get 100 immunotherapy regulatory approvals in 10 years. Excited to be part of this effort for the paper, for our field but most importantly for the people with
#cancer
we are working to
#cure
!
jitc.bmj.com/content/13/3...
6 months ago
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Tx
@theaacr.bsky.social
for highlighting our SITC
#Checkpoints
performance rocking the
#AACR25
annual reception in Chicago - Sunday, April 27. The best
#cancer
science & the best party! Hope everyone will be there!
@patrickhwumd.bsky.social
@ferranprat.bsky.social
www.aacr.org/blog/2025/03...
7 months ago
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reposted by
Jason Luke, MD, FACP, FASCO
Paul Rennert
7 months ago
and we provide some broader
#biotech
#bioblue
context
www.sugarconebiotech.com/insights/pd1...
add a skeleton here at some point
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reposted by
Jason Luke, MD, FACP, FASCO
Nature
7 months ago
Nature research paper: Spatial immune scoring system predicts hepatocellular carcinoma recurrence
https://go.nature.com/3Dr0HiQ
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Spatial immune scoring system predicts hepatocellular carcinoma recurrence - Nature
A publicly accessible toolโthe TIMES scoreโfor predicting the risk of recurrence of hepatocellular carcinoma is revealed, providing mechanistic insights into the prognostic patterns for hepatocellular carcinoma.
https://go.nature.com/3Dr0HiQ
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Amazing
@sitcancer.bsky.social
Spring Scientific on cell therapy in solid tumors! Appreciated op to discuss IMA203. One of the hottest agents in
#melanoma
& perhaps all of solid tumor oncology! Very excited that the SUPRAME Ph 3 study is now accruing pts!
clinicaltrials.gov/study/NCT067...
7 months ago
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reposted by
Jason Luke, MD, FACP, FASCO
Society for Immunotherapy of Cancer
7 months ago
New Journal for ImmunoTherapy of Cancer (
#JITC
) short report: Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors
bit.ly/43bFMuy
@jasonlukemd.bsky.social
@news.upmc.com
@djpinato.bsky.social
#OncSky
#CanSky
#research
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Enjoyed discussing LAG3 targeting
#melanoma
w
@drbetofmdphd.bsky.social
Major role for relatlimab while fianlimab data look as good/better so far! Field has been waiting long time for RELA-098 but Ph3 studies abound for cemi-fian metastatic, adjuvant and peri-op!
www.medscape.org/viewarticle/...
8 months ago
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reposted by
Jason Luke, MD, FACP, FASCO
Nature Biotechnology
8 months ago
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids -
@pennmedicine.bsky.social
go.nature.com/3EkClak
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Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids - Nature Biotechnology
Lipid nanoparticles carrying plasmid DNA and an inflammation inhibitor enable longer transgene expression than mRNA nanoparticles.
https://go.nature.com/3EkClak
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reposted by
Jason Luke, MD, FACP, FASCO
Riyue Sunny Bao , PhD
8 months ago
๐ Exciting news! The brand-new
#Y2025
#SITC
#CompIO
Webinar Series is here!!! ๐ Ten courses focusing on advanced methods and clinical utility for
#biomarker
#development
in IO
@sitcancer.bsky.social
@roswellpark.bsky.social
#NCI
๐ โจ FREE registration:
tinyurl.com/3863jp9t
Let's spread the word!๐
add a skeleton here at some point
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reposted by
Jason Luke, MD, FACP, FASCO
Riyue Sunny Bao , PhD
8 months ago
Integrating
#clinical
,
#pathological
,
#radiological
,
#transcriptomic
data boosts prediction of
#firstline
#immunotherapy
outcomes in metastatic
#NSCLC
๐ โจ317 patients, PET/CT, bulk RNAseq, digitized pathology =>
#Multimodal
#AI
outperform traditional methods!
t.co/MfMNwuZaG9
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Excited to speak
@sitcancer.bsky.social
Spring Scientific: Cellular Therapy for Solid Tumors - March 12โ14, San Diego. I'll discuss Development, Clinical Efficacy & Translational Analysis of PRAME Targeting with TCR Transduced T cells via IMA203. Please join us!
www.sitcancer.org/education/sp...
9 months ago
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reposted by
Jason Luke, MD, FACP, FASCO
Waggoner Lab
10 months ago
Cellular RNAs directly regulate the activity of an antiviral immune signaling complex
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
@nandangokhale.bsky.social
@ramlabuw.bsky.social
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Appreciated interview
@oncodaily.bsky.social
to discuss trends in cancer
#immunotherapy
, my work, as well as the role of professional societies & mentorship in career development. Focus on what you are passionate about, find great mentors & GRIND! Happy holidays!
www.youtube.com/watch?v=HZqA...
10 months ago
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Looking forward to moderating this
@sitcancer.bsky.social
Deep Dive into Co-stim along w Taha Mergoub featuring 3 tremendous talks from rising stars Mohamad Hamieh, Juan Osorio & Roberta Zappasodi covering novel strategies, ICI combos & CART. Please register & join us!
sitcancer.org/education/we...
10 months ago
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Thanks
#ASCO
for this recognition as a Fellow! Its an honor contributing to ASCO's important work for patients, providers & the health care community. Onward then in conquering
#cancer
via research, ed & the highest quality, equitable patient care! See you
#ASCO25
!
society.asco.org/about-asco/a...
10 months ago
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