Great #iSCMS2025 poster by @mari-mardamshin.bsky.social, who presented mxDVP, integrating high-plex microscopy with ultra-sensitive MS to explore pancreatic islet heterogeneity at unprecedented resolution. Evosep One with Orbitrap Astral / timsTOF SCP, with Aurora Elite columns on both instruments.

Honored to be featured in the Researcher Spotlight by @ionopticks.bsky.social, sharing my path to spatial proteomics and our efforts to build pipelines that decode cellular complexity and uncover hidden states. #massspectrometry #spatialbiogy #proteomics #singlecell #multiplexedimaging #dvp

A portion of ye ole MS populace .. go.bsky.app/3XETWrh

Excited for the talk ✨🚀✨ #ASMS2025 #NASA #teammasspec #DRAGONFLY

🎉 Excited to share our work at #ASMS2025! Come visit Poster WP300 to learn about our Multiplexed DVP (MxDVP) workflow - a streamlined approach integrating #high-plex #imaging and ultra-sensitive #MS for spatially resolved cell states. Let’s talk #spatialbiology and #single-cell depth! #teammassspec

Nano-scale, mega-impact: nanoPhos delivers 100× phosphoproteomics sensitivity, 70k sites from 1µg, 8k from 10ng! Powered by SPEC, it enables phosphoDVP: deep spatial phosphoproteomics from 1000 neurons, hitting 17k sites, a game changer for spatial omics. www.biorxiv.org/content/10.1...

🌅 What a fantastic start to the day here in Baltimore! Joined the 5K charity run this morning: great company, perfect views, and all for a wonderful cause. Huge thanks to @sciex.bsky.social for organizing such an awesome event! #ASMS2025 #SCIEXRun #teammassspec

On my way to Baltimore for #ASMS2025! Excited to reconnect and dive into cutting-edge mass spectrometry. Any must-see sessions or cool poster recommendations from the #teammassspec community? Looking forward to your suggestions!

Excited to share our new preprint: PIPΣX — an open-source, no-code pipeline for automated multiplexed tissue image analysis. Works across platforms & organs. Explore here: www.biorxiv.org/content/10.1... Looking forward for your feedback! #spatialbiology #opensource #multiplexedimaging #massspec

Excited to share our preprint on multiplexed DVP! mxDVP extends CODEX to DVP family, revealing spatial heterogeneity in human pancreatic islets with 12 endocrine sub-types including rare polyhormonal cells. Fantastic team effort #LundbergLab biorxiv.org/content/10.1101/2025.04.27.650857v1

So excited to share our preprint! We developed multiplexed Deep Visual Proteomics(mxDVP) to deeply profile human pancreatic islets at spatial single-cell resolution, and identified rare endocrine states #SpatialOmics #Proteomics #SingleCell #IsletBiology #OpenScience www.biorxiv.org/content/10.1...

Have you already heard about the #ProteomicsMap ? Check it out and find out what great labs are out there, to get help in your projects, collaborate, and network! Check it out here 👉 eupa.org/map/ . Also, don't forget to register 🫵 your proteomics group group.bspr.org/group/register !

Had the opportunity to join the the SAMBAI SPEAKS podcast, together with Dr. Roads, Dr. Olanipekun, and our patient advocate Lluvia Del Rio. In this episode, we talked about work on the PROMINENT project, how we're exploring cancer development and why prevention deserves more attention in research.

Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. www.nature.com/articles/s41...

Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood. nature.com/articles/s41588-025-02089-2 #PediatricProteomics #pQTL First author @liliniu.bsky.social explains ⬇️

A Quantitative Proteome Map of the Human Body . www.cell.com/cell/fulltex...

Our Deep Visual Proteomics workflow maps protein networks in bladder, prostate, seminal vesicle & lymph node Signet Ring Cell Carcinoma, revealing DNA damage response alterations & immune signatures that could guide therapy choice. Out now in NPJ Precision Oncology! rdcu.be/d8KyK

DIA-NN 2.0 is released! We consider it the biggest step forward in the history of DIA-NN. On modern LC-MS almost all identifications are now peptidoform-confident, with major improvements e.g. for phospho. Some other cool things too: github.com/vdemichev/Di...

Calling all #TeamMassSpec experts. I’m planning to revisit the classic SCX fractionation protocol but ran into a challenge - I can’t find a vendor for syringes with metal springs to make stage tips. I’d be so grateful for any suggestions or advice you might have 🙏 *attaching picture as an example

The research community has flocked to the social-media platform Bluesky. Tell us about your experience https://go.nature.com/42fihQG

Spatial Proteomics was named as the method of the year 2024 🌟 #spatialproteomics #proteomics #teamscience #researchmethods www.nature.com/articles/s41...

That one is pretty much full, but I can add you both to the early career pack, we could use some company there 🙂 go.bsky.app/Dp8PHX1

#teamMassSpec here is a starting pack in case you just moved over, or in case you've been absent for a while. This is #proteomics or #massspec related. The pack is not comprehensive but it's a start. go.bsky.app/HH7kqEh