We have developed hyper-migratory CAR T cells that alleviate ovarian cancer metastatic burden and improve prognosis. We transduce synthetic modular "velocity" receptors that promote fast and deep infiltration of CAR T cells into mets in the liver. More here: www.biorxiv.org/content/10.1...

Please start following @natbiomedeng.nature.com! It's an alive account now and we will start posting good content!

Fantastic thread on metastasis and causes of cancer-related deaths.

Comparing single-cell #SpatialTranscriptomics methods on FFPE human tumor #TissueMicroArray CosMx 1k vs MERFISH 500 vs Xenium-UM/-MM 339 93 common genes lung adenocarcinoma pleural mesothelioma Corr. Bulk RNAseq, GeoMx #NatureComms 2025 www.nature.com/articles/s41...

Multimodal SRS imaging reveals metabolic remodeling in ovarian precancerous lesions. In collaboration with Prof. Lingyan Shi (UCSD), we integrated spatial metabolomics into a new 3D tissue mapping workflow at single-cell resolution More here: www.biorxiv.org/content/10.1...

It's probably the deterioration of social media (I hope) but i'm exposed to a lot less cool science. It used to feel like a new cool study is being preprinted/published every week, and lately it's rare (at least so it seems). Share a recent study that's worth knowing!

Check this out: This is what the human fallopian tube looks like as one travels through its different sections. We have developed a new 3D single-cell tissue mapping workflow to automatically/accurately detect ovarian cancer precancerous lesions (STICs). More here: www.biorxiv.org/content/10.1...

Our new workflow maps whole human fallopian tubes at single-cell resolution. In healthy FTs, we detected (many) STIC precancerous lesions. We can also simulate virtual sectioning as done in the clinic and show how current protocols undersample FTs. More here: www.biorxiv.org/content/10.1...

Using a new workflow, we map ciliated (green) and secretory cells (pink) that line the epithelium of whole human fallopian tube. With age (menopause), the number of ciliated cells decreases and the number of secretory cells increases. More here: www.biorxiv.org/content/10.1...

This work was done by an amazing team of PhD students, undergraduate students, postdoctoral fellows, and wonderful colleagues at Hopkins, Yale (Rong Fan, Xiaoyu Qin, and Mei Zhong), UCSD (Lingyan Shi and Yajuan Li), the Max Planck Institute (David Zwicker), and U. Florida (Mark Atkinson and team).

We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics. We applied this workflow to map precancerous lesions of the fallopian tubes. More here: www.biorxiv.org/content/10.1...

On my way to CICON 2025 where I’ll present our recent work on CAR T therapies for solid tumors and incredibly exciting 3D mapping results on precancerous lesions of ovarian cancer (in the fallopian tube)

Grateful I live in a neighborhood in DC where there’s a proper bakery Breadfurst

Inspired by @deniswirtz.bsky.social and team, I'm collating a database of #PhD and #postdoc fellowships in the #EU. I'm standardising the information an entry needs, making it easier to (1) search and (2) contribute - and I would appreciate input, especially from other #ECR! Please share! 1/3

Human endometrial tissue mapped using CODA red: endothelial cells; yellow: epithelial cells, purple: stromal cells. More about endometrial tissue mapping: www.biorxiv.org/content/10.1... More about CODA: www.nature.com/articles/s41...

In our new paper, we use a new 3D single-cell reference map to guide the design and validation of a new multi-compartment assembloid that mimics the function and architecture of the human endometrial tissue, exhibiting stromal decidualization. More here: www.biorxiv.org/content/10.1...

We will post soon two major papers on women’s health. The first paper could change clinical practice for the early detection of ovarian cancer. The second paper shows the creation of new cell assembloid that reflects the complex composition and architecture of endometrial tissue mapped in 3D.

Dark clouds over Shriver Hall at Hopkins

Download our database of POSTDOC fellowships for cancer research/oncology in the US. We found 46 different fellowships. For each entry, we provide link, description, deadline, amount, eligibility criteria. Good luck! Here: research.jhu.edu/rdt/funding-...

Download our updated database for POSTDOC fellowships in neuroscience/neurology/psychology/psychiatry/neuro-X 23 entries (w/ description, amount, link, deadline, eligibility criteria). Good luck! Here: research.jhu.edu/rdt/funding-...

These are the most challenging times for early-career scientists and engineers. My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers. We found 437 of them. Download it freely here: research.jhu.edu/rdt/funding-...

My team has updated our free database of POSTDOC fellowships. This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria. Download this updated and expanded database here: research.jhu.edu/rdt/funding-...

The updated version of the database of PhD fellowships produced and maintained by my team can be downloaded by anyone here: research.jhu.edu/rdt/funding-... For each of the 187 fellowships, you will find a short description, deadline, $ amount, link, etc. Good luck!

Please share my 1 min video on the importance of maintaining NIH funding of infectious diseases and drug discovery research vs rising antibiotic resistance Drastic budget cuts harm our health and imperil the next generation of scientists More @UCSanDiego “Behind Every Breakthrough” bit.ly/3FlXQs3

🎧 New #PancChat episode: "What You Need To Know About Screening for Pancreatic Cancer" @AlisynCamerota talks with Dr. Anirban Maitra & Dr. Michael Goggins about who should get screened, when to start, and the future of early detection including AI advances.

Dreamy gardens by Belgian landscape architect Jaques Wirtz

So much trouble in the world is people who fundamentally can't handle competition....

Excited for this @cp-cell.bsky.social article co-led by @fertiglab.bsky.social and Genevieve Stein-O'Brien, on creating a plain language "grammar" to easily write simulation models as virtual laboratories for complex systems like cancer. Fully open access and open source! 🧪 #mathonco #mathbio

Really excited to share our new @cellpress.bsky.social Cell paper with @fertiglab.bsky.social and colleagues. 1/n www.cell.com/cell/fulltex... @jktgfoundation.bsky.social @itcrtraining.bsky.social @smbmathbiology.bsky.social #mathbio #mathonco @mathonco.bsky.social @deniswirtz.bsky.social

Magical Portugal

My PhD student just showed me the most amazing results for this CAR T therapies. It never gets old.

This gap in biomedical research funding between FY24 and FY25, it's new therapies that won't see the light of day, researchers moving away from science, and the evisceration of American research universities, which were until recently the envy and a model for the world.

Grant terminations have grabbed the headlines and have seen legal action, but even more damaging to the US research enterprise has been the massive decrease in number of research grants issued by federal agencies NIH has seen a decrease of 57% in the number of awards & 63% in value compared to FY24

How Trump’s crackdown on universities is affecting the world www.nytimes.com/interactive/...

Magritte Magritte Museum, Brussels

The N.I.H. has terminated hundreds of diversity grants awarded to young researchers, many of whom come from the very places that supported Trump. www.nytimes.com/2025/07/10/u...

We would not have our GPS. We would not have airlines. We would not have the drugs we have. That all came out of public scientific investment. There's a large literature which shows that the rate of return to public R&D is outsized. It's enormous. 6/n

Stolen by the French after the revolution (and returned to Belgium after the Battle of Waterloo), then by the Germans in WW1 and under a direct order of Hitler in WW2.

Mystic lamb in its modern context

Hubert and Jan Van Eijk’s “The Adoration of the Mystic Lamb” is magnificent. Displayed in the St Bavo Cathedral in Ghent, Belgium Had to see it, again.

Summary Table of the massive defunding of biomedical research in the United States www.nytimes.com/interactive/...

it breaks my heart to see such an amazing place as Hopkins being undermined by an ascendant ideology that denies scientific truths and demeans humanity's values

Ive - Warmest welcome to Hopkins. You’re joining an amazing community of researchers. We’re lucky to have you.

On my way to Bruxelles La belle Looking forward to ESCAPE 25 in Leuven, where I’ll give a talk on AI in organ and tumor 3D mapping

Gilman Hall at Homewood Johns Hopkins University

Johns Hopkins Gets the Most Federal Money, but Now Much of It Is at Risk "The university’s troubles show how a Republican campaign against higher education could decimate the nation’s research enterprise" www.nytimes.com/2025/06/26/u...

The FY26 budget will devastate our innovation driven economy. A summary in 3 parts... Part 1 - The White House vision for dismantling science, as described in one simple plot, means slashing budgets of NIH, NASA, NSF & going back 25 years (or more). joshuasweitz.substack.com/p/the-white-...

Much appreciated support from biotech execs and investors 🙏 www.statnews.com/2025/06/27/b...

Ted Koppel interviews my Hopkins colleague Prof. Liz Jaffee, world expert in pancreatic cancer, about the devastating cuts and slow roll out of cancer research funding by the NIH. See this CBS Sunday morning show video here: www.youtube.com/watch?v=CLwc...

Human monocytes form ordered patterns on soft matrix via Turing-like local activation and global inhibition. Like active materials, only better. More here: www.biorxiv.org/content/10.1... Will appear soon.