We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.

Hey @jamieheather.bsky.social what do you think of this? www.biorxiv.org/content/10.1...

Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...

Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy @natcancer.nature.com www.nature.com/articles/s43...

Excited to announce that I’ve recently transitioned into an Assistant Professor role in the Division of Translational Science and Therapeutics @Fred Hutch.

Check out one of our latest stories about combining our non viral knock-in strategy with integrases for an efficient, targeted integration of transgenes >8kb in human T cells! ‘One-pot’ PASTA: programmable and site specific transgene addition - all in just one reaction 🫕

Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+ Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade www.biorxiv.org/content/10.1...

Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade https://www.biorxiv.org/content/10.1101/2025.04.10.648245v1

Exciting news! Our latest manuscript is out! Really happy to report on the development of synthetic chimeric TCRs with enhanced antigen sensitivity and capable of bispecificity to successfully overcome tumor heterogeneity in pre-clinical models. Check it out: rdcu.be/edRwJ

Flow cytometry batch effect correction without requiring normalization controls 🤩 onlinelibrary.wiley.com/doi/full/10....

Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social Please share widely! www.youtube.com/watch?v=yxTD...

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