Developmental Mutators: A unified theory of why young people develop cancer ☛ alexkentsis.net/lecture-deve...

@kentsisresearch.bsky.social develop a proteogenomics workflow to detect 1000s of unknown cancer proteins. PG3 combines long-read RNA sequencing with multi-protease MS to discover non-canonical proteins in cancer cells. Used a timsTOF HT, nanoElute 2 & Aurora Ultimate 25x75 column: bit.ly/4mlQSmu

A deep dive into the destruction of US cancer research by @jonathanmahler.bsky.social “It’s an absolutely unmitigated disaster,” a former top official at NIH told him. “It will take decades to recover from this, if we ever do.” Gift link: nyti.ms/48iH3Cr

Listen to my new lecture "Developmental mutagenesis: A unified theory of why young people develop cancer" as part of @stjude.bsky.social @stjuderesearch.bsky.social Science of Childhood Lecture Series on September 18, 2025: www.linkedin.com/events/73719...

These are the most challenging times for early-career scientists and engineers. My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers. We found 437 of them. Download it freely here: research.jhu.edu/rdt/funding-...

Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study - The Lancet Oncology www.thelancet.com/journals/lan...

NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus! www.nature.com/articles/s41... #alphafold #evolution #genomics

Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis 🧬🩸 screen of fully synthetic enhancers in blood progenitors 🤖 AI that creates new cell state specific enhancers 🔍 negative synergies between TFs lead to specificity! www.cell.com/cell/fulltex... 🧵

Supporting medical science in the USA - The Lancet www.thelancet.com/journals/lan...

What would the National Cancer Act look like today? Bravo Kevin Cullen! Act! cancerletter.com/guest-editor...

New in @naturecomms.bsky.social: MSK's @kentsisresearch.bsky.social & collaborators identified a rare population of stem cells responsible for disease persistence & therapy resistance in acute myeloid leukemia (#AML), which could help improve treatment strategies: www.nature.com/articles/s41...

A new KRG study led by Sumiko Takao @naturecomms.bsky.social uncovers how epigenetic mechanisms control human leukemia stem cells (LSCs) that fuel therapy resistance in AML. www.nature.com/articles/s41...

A little lab fun

I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less! authors.elsevier.com/c/1kjdaL7PXu... How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it. #Retrovirus #koala #piRNA More below 👇

After many years of explaining trainees how to review scientific manuscripts well, I've summarized them here: docs.google.com/document/d/1...

Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/10.1126/...

New book out: Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults alexkentsis.net/book-develop...

Join us as a Research Technician in the Kentsis Lab externaltalent-mskcc.icims.com/jobs/83429/r...

Wow! Unlikely contamination because of isotope distributions and racemic mixture. Wow! www.nature.com/articles/s41...

Looking forward to the CCRI Symposium on Cancer Epigenetics next week: ccri.at/st-anna-ccri...

Come to #KSPrecisionOnc25 and hear @yaniv.kazansky present the latest on rational epigenetic and synthetic combination therapies for sarcomas: www.keystonesymposia.org/conferences/...

Here is a recent #MSKKids lecture @mskcancercenter.bsky.social: Toward a unified theory of why young people develop cancer ☛ alexkentsis.net/wp-content/u...

Great to see "Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults" with Alejandro Gutierrez and many co-authors coming out from CSHL Press www.cshlpress.com/default.tpl?...

#MSKKids is bringing smiles to our pediatric patients @mskcancercenter.bsky.social

KRG is ready