We are hiring ! 👩🏼‍🎓👨‍🎓🧑🏼‍🎓👨🏿‍🎓👩🏿‍🎓👩‍🎓 I am looking for a motivated person interested in a PhD in basic neuroscience, for a project at the edge between epilepsy and sleep. If you are interested, check the job announcement: jobs.unige.ch/www/wd_porta...

This asymmetry is highly patient-specific and supports the hypothesis that generalized discharges are shaped by delimited areas of cortex. doi.org/10.1111/epi.... #epilepsy #epilepsia #ILAE #amplitude #discharges #EEG #generalized #symmetry

Thrilled to have been awarded an Ambizione grant from the @snsf.ch ! I will work under the auspices of Pr Serge Vulliémoz, Pr @anitaluthi.bsky.social and collaborate with Pr Matthew Walker (UCL), Dr Daniel Bush and Dr Tawfeeq Shekh-Ahmad for a project on epilepsy and sleep.

Deep learning for epilepsy ! An impressive work by Sundrani and colleagues demonstrates the ability of convulational neural network to predict seizure onset zones --> doi.org/10.1111/epi....

Interneurons promotes microglial activation, ultimately leading to phagocytosis of inhibitory synapses --> part of the mechanism of temporal lobe epilepsy? doi.org/10.1038/s415...

Just published my first paper! Really grateful to everyone at the plasticity lab @oxcin.bsky.social who made this possible. huge thanks to my co-authors — couldn’t have done it without you. If you want to check it out: 📄 paper: www.nature.com/articles/s41...

Pint of Science in Geneva! This week. Program here: pintofscience.ch/events/geneva @pintofscience.ch

doi.org/10.1038/s415... @anitaluthi.bsky.social

Thorough electrophy study on cortical stimulation --> www.nature.com/articles/s41.... Fascinating to see this complex network elicited by 'artificial' stimulation. Well done @simonerusso.bsky.social and team!

Encouraging phase 2 trial in fronto-temporal dementia ->

Excited to take part in tomorrow's webinar organized by the Young Epilepsy Session (YES) of the International League Against Epilepsy (ILAE). I will be discussing mechanisms of generation of HFOs and why this is important for clinical practice. @ilae-epilepsy.bsky.social

Disrupting synaptic transmission affects sleep-wake dynamic --> www.cell.com/current-biol...

At the MicMac conference in Toulouse, listening to talks on HFOs, and look what comes out in Brain Communications: doi.org/10.1093/brai...

Mosaicism in the brain: doi.org/10.1093/brai... Complexity should be seen as an opportunity...

Coupling of spindles to slow waves is important for memory, but this is disrupted in people with epilepsy --> doi.org/10.1111/epi....

Exciting work where we address the mechanisms underlying long held epidemiological associations between epilepsy and sleep. Thanks to all co-authors: Birgit Frauscher, Christophe Bernard and Matthew C Walker. Thanks to my funding: @snsf-ch.bsky.social Guarantors of @brain1878.bsky.social

Is sleep the worst enemy of epilepsy? Is it promoting or preventing seizures? And how? We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology: doi.org/10.1038/s415... @natrevneurol.bsky.social

Thalamic activity during wake and sleep in 121 people with epilepsy --> academic.oup.com/braincomms/a...

Can you learn while sleeping? Does sleep help you solve problems? What is the effect of sleep on brain metabolism? --> my last editorial @braincomms.bsky.social doi.org/10.1093/brai... Sleep is not a homogenous state - just like wake. Asking the role of sleep is as fair as asking the role of wake!

How can we improve the chance to record seizures during intracranial monitoring of people with drug resistant epilepsy? Interesting to see that sleep deprivation does not contribute (reminds me of the works by Malow!) --> doi.org/10.1111/epi....

Pupil size as an index of sleep states --> www.nature.com/articles/s41... See also www.nature.com/articles/s43... Sleep goes beyond the classical NREM/REM stages and pupil size might be a candidate tracker of these more subtle states.

Very interesting paper by Alfonsa et al. @currentbiology.bsky.social. Switch in EGABA associated with long period of wakefulness shapes LTP. @vyazovskiy.bsky.social doi.org/10.1016/j.cu...

Great work on substantia nigra and locus ceruleus microstructural abnormalities in REM sleep behavior disorder and Parkinson's disease. Now in @braincomms.bsky.social doi.org/10.1093/brai...

Sleep matters! doi.org/10.1038/s415...

The inferior fronto-occipital fasciculus: from structural to functional anatomy. Here is a great review in @brain1878.bsky.social doi.org/10.1093/brai...

High-density electrocorticography in epilepsy surgery --> doi.org/10.1111/epi....

A new study in Brain Comms included 84 people with epilepsy due to hippocampal sclerosis and 43 controls to test how structural abnormalities shape verbal memory. @dgiampiccolo.bsky.social @braincomms.bsky.social doi.org/10.1093/brai...

A very exhaustive review on EEG --> doi.org/10.1111/epi.... Well done @chrislisgaras.bsky.social

Dreams in people with epilepsy: doi.org/10.1111/jsr....

Memory consolidation during sleep involves hippocampal-neocortex intercations with a particular role of sharp-waves ripples and UP (i.e., excitable)/DOWN (i.e., silenced) neural states. This new paper investigates mechanisms enabling this coupling --> doi.org/10.1016/j.ne...

Job opening at Jabaudon lab in Geneva, Switzerland. !

A role of slow wave activity in post-ictal delirium? I can't help but think about the link with H Blumenfeld works... doi.org/10.1016/j.cl... doi.org/10.1016/j.ne... doi.org/10.1016/j.ce...

The cingulum is involved in so many functions, probably owing to its location and extension from anterior to posterior brain regions. Here is now a great review on its anatomy and connectivity --> doi.org/10.1093/brai... Great figures btw, think of this paper for your next presentation/talk 😉

Late onset unexplained epilepsy: increased likelihood of cognitive impairment, especially in drug-resistant subjects. Are seizures responsible or is there a common physiopathological pathway underlying seizures and cognitive problems? doi.org/10.1093/brai... @braincomms.bsky.social

Infantile epileptic spasms: histopathology, imaging and genetic testing in a large cohort. Multimodal testing is necessary for accurate diagnosis --> @braincomms.bsky.social doi.org/10.1093/brai...

Role of calcineurin in sleep homeostasis regulation --> www.pnas.org/doi/10.1073/...

How AI can help imaging studies in epilepsy --> doi.org/10.1093/brai...

Microstructural abnormalities in people with REM sleep behavior disorder and Parkinson's disease; focus on locus ceruleus and substantia nigra --> academic.oup.com/braincomms/a...

@brain1878.bsky.social @braincomms.bsky.social

Next BRAIN conference: 7 March 2025. Register here (til 21-Feb) --> conference.guarantorsofbrain.org/registration/ Abstract submission here (til 31-Jan) --> conference.guarantorsofbrain.org/poster/ We have built up a great program across movement disorders, cognition/dementia and neuroinflammation.

Just making sure everyone saw this great review on neuronal bistability and slow waves in brain injuries. "Intrusion of sleep-like dynamics after brain injury". www.nature.com/articles/s41...

Role of glial cells in sleep regulation --> doi: 10.1093/sleep/zsae314

Seizures are rare during REM sleep, but they can still occur during this stage. New work by the team of Marcus Ng --> doi.org/10.5664/jcsm...

New online! Brain stimulation aids walking after spinal injury https://bit.ly/4hhWCf1

How does memory evolve after epilepsy surgery? For the better it seems! --> doi.org/10.1038/s414... @uclqsion.bsky.social @dgiampiccolo.bsky.social

How to diagnose epilepsy, when there is no EEG trace of epilepsy? --> onlinelibrary.wiley.com/doi/10.1002/...

In children with Rolandic epilepsy - a frequent cause of focal epilepsy in children - sleep spindles are reduced and this correlates with impaired memory. www.neurology.org/doi/10.1212/...

That's a fascinating topic! Related to that, we will have a talk by Pr. David Attwell at the next BRAIN conference (London, 7-March-2025). Registration open conference.guarantorsofbrain.org/registration/ @braincomms.bsky.social

Microarousals: neither good or bad (or both at the same time...) - everything is about balance. www.sciencedirect.com/science/arti...