Join the coolest club on the internet! #EpithelialMechanics

Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉 👉 epithelialmechanics.github.io Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them. Would you like to share your story? Please DM us!

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social : "Self-organization of tumor heterogeneity and plasticity" biorxiv.org/content/10.1... Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated? A thread👇

Epithelial crowding drives membrane depolarisation by ENaC/Na+ entry which triggers rapid volume loss, piezo activation and live cell extrusion. Importantly, low intracellular ATP primes cells for live extrusion by preventing the restoring of mb polarisation. www.nature.com/articles/s41...

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations. The tissue morphogenesis logic, now engineered into living, programmable materials. www.biorxiv.org/content/10.1... #ActiveMatter #TissueEngineering

🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨ “A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶 🔗 www.biorxiv.org/content/10.1... #devbio #biophysics 🧵⤵️

Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision www.biorxiv.org/content/10.1...

🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻‍🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)

1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵 Read more: www.nature.com/articles/s41...

How oncogenic clones can eliminate their neighbours to take over space ? There are different ways combining growth and interfacial tension induced compaction. Check out our latest preprint led by Léo Valon and Alexis Matamoro-Vidal to learn more about this 👇 www.biorxiv.org/content/10.1...