Nicolas Bidere (@nbidere.bsky.social)

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset... https://www.science.org/doi/10.1126/science.adq8331#:~:text=By%20re-constituting%20LyLAP-depleted%20lysosomes%20with%20recombinant%20LyLAP%20protein%2C,consist%20of%20hydrophobic%20amino%20acids%2C%20such%20as%20leucine