How are RNAs presented on the cell surface without any transmembrane domains? In our paper published at Molecular Cell @cp-molcell.bsky.social, we provide mechanistic insights into this pressing question. They form ternary complexes with RNA-binding proteins and heparan sulfate proteoglycans.

Now finally peer-reviewed and published in @springernature.com Experimental & Molecular Medicine (EMM)🥳: www.nature.com/articles/s12... Our story was published back-to-back with the intriguing paper by Kim et al.: www.nature.com/articles/s12...

Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field. 1. RNA-associated glycoconjugates highlight potential ambiguities in glycoRNA analysis 2. Proteins are a source of glycans found in preparations of glycoRNA

#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇 Kim et al. rdcu.be/eP4GQ @nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)

Very interesting work: "Pseudouridine selects RNAs for extracellular transport" www.biorxiv.org/content/10.1...

(1/2) Excited to share our new paper in @rheumjnl.bsky.social.We show that soluble BDCA-2 is elevated in rheumatoid arthritis and boosts IFN-α responses via nucleic acid binding. #Rheumatology #Diagnostics @unimarburg.bsky.social academic.oup.com/rheumatology...

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

New research shows that simply changing how a reaction vessel is positioned on a magnetic stirrer can significantly change a reaction's speed and product quality, influencing the reproducibility of results. #ChemSky #ScienceSky #EduSky

#savealldogs #dogs #dogsrule

🤔 www.nature.com/articles/s41...

A highly interesting read from Hazemi et al., investigating the incorporation of a panel of azido sugars into RNA preps. Includes investigations of the high apparent MW shift of glycoRNA, the testing of proteinase K protocols, and non-enzymatic glycoRNA labelling. pubs.acs.org/doi/full/10....

PhD Timeline xkcd.com/3081

Here is an updated version of a preprint posted in 2024: It describes a non-RNA glycoconjugate persisted throughout RNA sample processing, with similar electrophoretic properties and enzymatic reactivity as glycoRNA. It confounds gel-/blot-based glycoRNA assays. www.biorxiv.org/content/10.1...

The massive changes in US research brought about by the new administration of President Donald Trump are causing many scientists in the country to rethink their lives and careers https://go.nature.com/41OhAgK

Excited to share an update on heparan sulfate (HS)-associated cell-surface RNA (hepRNA): www.biorxiv.org/content/10.1...

Excited to share our preprint about proteins that we found in preparations of glycoRNAs now available on bioRxiv! #glycotime (1/9) www.biorxiv.org/content/10.1...

Proteins are a source of glycans found in preparations of glycoRNA https://www.biorxiv.org/content/10.1101/2025.03.17.643711v1