Happy to share our latest work, 'Integrating targeted genome mining and structure-guided modeling reveals unexplored 7-deazapurine-containing pathways.' 1/n www.biorxiv.org/content/10.6...

Now out in @acs.org JACS Au, the manuscript by #BarbaraTerlouw et al. describing PARAS, a high-accuracy machine-learning algorithm to predict substrate specificities of nonribosomal peptide synthetase (NRPS) adenylation domains, key for estimating natural product structures from BGC sequence. 1/n

Now out in @natcomms.nature.com : versions 2.0 of both BiG-SCAPE and BiG-SLiCE! With significant speed and accuracy increases, as well as new interactive functionalities. Read the full paper here #openaccess: www.nature.com/articles/s41...

The MIBiG 5.0 Annotathon is coming soon, and registration is now open! 🧬 Does your research involve biosynthetic gene clusters? Do you love natural product biosynthesis? Do you have an interest in rare & exotic enzymes? We can use your help & expertise. Register here 👉 forms.gle/C1cWcLHtrjT2...

I am delighted and feel honored to be appointed as chair of Bioinformatics at @w-u-r.bsky.social . I look forward to working with the team and with our collaborators worldwide on keeping bioinformatics science and education flourishing at WUR and beyond. www.wur.nl/en/news/marn...

Excited to share EquilibraTor, our new pipeline that streamlines molecular dynamics simulations for proteins, protein–ligand, and protein–protein systems! Faster setups. Automated workflows. Useful from drug-discovery binding work to enzyme-mechanism insights. www.csbj.org/article/S200...

Working on tailoring enzymes and want to learn more about the MITE database? We are organizing a hands-on training session on how use the DB and create new entries: October 30th and November 4th 10-11 am Amsterdam time. Sign up here: forms.gle/KHPqe9XV1RRg... See you there! #secmet #natprod

I’m excited to share the first paper from my lab that was led largely by undergraduate students at University of Wisconsin and Washington College! #secmet #natprod www.frontiersin.org/journals/mic...

Aaand it's out! Meet MITE - the natural product tailoring enzyme database, just published in @narjournal.bsky.social! MITE DB captures the substrate- and reaction-specificity of tailoring enzymes, allowing to capture this information in a human- and machine-readable way! doi.org/10.1093/nar/...

Happy to share our newest preprint. PhyloNaP as a user friendly database of phylogeny for enzymes involved in natural product production and as public repository for well curated phylogenetic trees. Happy Tree Building!!! #phylogeny #secmet #bioinformatics www.biorxiv.org/content/10.1...

Now out as preprint: versions 2.0 of both BiG-SCAPE and BiG-SLiCE have been released! With significant speed and accuracy increases, as well as new interactive functionalities. www.biorxiv.org/content/10.1...

We are looking for a 3-year postdoc to work with Daniel Probst, Justin van der Hooft and myself on an exciting project involving federated learning and integrative omics for discovery of new antibiotics from natural products. Apply here: www.wur.nl/en/vacancy/p... Please share!

⏰ Just 7 days left for our Glycopeptide Renaming Challenge! 💡 Share your best name idea and win 500€ 👉 More info and submission here: docs.google.com/forms/d/1ym9... #secmet #NaturalProducts #Antibiotics #NamingChallenge #Glycopeptides @gdwantibiotics.bsky.social @marghesosio.bsky.social

*JOB AD*: interested in doing a postdoc in microbial metabolomics? Passionate about natural products mass spec? Come join the group! Informal enquires welcome! Closing Date: 19 August 2025 jobs.ncl.ac.uk/job/Newcastl...

Here's a fun perspective piece on Cyanobacteria as prolific natural product producers with great potential for drug discovery. Thanks especially to @philmuslab.bsky.social for ringleading and letting us contribute! pubs.rsc.org/en/content/a...

GATOR-GC is out at @narjournal.bsky.social!! Check out our new targeted genome mining tool featuring a novel similarity metric to efficiently compare and deduplicate gene clusters. We uncover biosynthetic diversity missed by other genome mining tools academic.oup.com/nar/article/...

A decade ago, we had thousands of bacterial genomes. Now, we have millions. How to scale computational methods? Our paper in @naturemethods.bsky.social answers this: use evolutionary history to guide compression and search. rdcu.be/eg4OA w/ @baym.lol, @zaminiqbal.bsky.social et al. 🧵1/

#JNatProd celebrates inspiring contributions of early career researchers to the field of natural products. 20 authors from 12 countries across 5 continents are highlighted – learn about them and their research here pubs.acs.org/page/jnprdf/...

antiSMASH8: The Ocho Manuscript is out! doi.org/10.1093/nar/...

GATOR-GC preprint is live! If you haven't already, check out our new tool for targeted gene cluster mining. @jcedielbecerra.bsky.social doi.org/10.1101/2025...

Our new review article "Microbial secondary metabolites: advancements to accelerate discovery towards application" in Nature Reviews Microbiology is now published! rdcu.be/d6BHX

www.biorxiv.org/content/10.1... #secmet 🧪🖥️🧬

Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...

Our new paper is published in Scientific Data describing the genome sequences of 121 Bacillales isolates from all around the world -together with @tilmweber.bsky.social Joint DTU-BGI PhD project and nice collaborative effort providing the isolates www.nature.com/articles/s41... #Bacillus

Scripps Institution of Oceanography, UCSD is looking for an assistant prof in marine natural products / marine biotech apol-recruit.ucsd.edu/JPF04101 #naturalproducts

If you’re interested in Streptomyces, other filamentous actinomycete bacteria and their natural products follow @ActinoBase. Linked to our wiki at actinobase.org. Please share.

Very pleased to announce that our manuscript describing @jgi.doe.gov 's Secondary Metabolism Collaboratory is now available! SMC has been up and active for a while now, but I'm really excited to start seeing more activity on here. Lots more to come. doi.org/10.1093/nar/...

Our paper introducing the Secondary Metabolism Collaboratory (SMC) containing 13M BGCs from >1.3M genomes is just out: doi.org/10.1093/nar/... Access SMC at smc.jgi.doe.gov

If you’re interested in microbial specialized metabolites #naturalproducts - we’ve compiled a list of useful bioinformatics / community resources - it’s not meant to be comprehensive- just somewhere to start - let us know if you find it useful 😊 #microsky #secmet

Natural product researchers, do you first hear about conferences when your PI says "I'll be gone next week"? Here's a list of upcoming events for those who work on secondary/specialized metabolites, along with their deadlines: tinyurl.com/NP-events Thanks to those who have submitted events!

The JGI’s Secondary Metabolism Collaboratory, SMC, version 1.0 is released! This is JGI’s database of natural product BGCs. The current version contains BGC info from AntiSMASH 7 and EmeraldBGC for as many bacteria as we could find (~1.3M genomes). smc.jgi.doe.gov or secondarymetabolism.com 1/n 🧪🧬🖥️

In case you missed it, the Secondary Metabolism Collaboratory is coming out of open beta soon! What's SMC? Check out my blog post on the site! smc.jgi.doe.gov/blog/

I'm so excited to be hosting Amy Lane for a blockbuster seminar. "Unleashing the Potential of Marine Actinomycetes as Biochemists" is scheduled for 12:30p tomorrow in UF MCS. Be there!

Come work with us!! Lecturer / Senior Lecturer in Antimicrobial Drug Discovery at Newcastle University @nubiosciences! Please RT #AMR #DrugDiscovery #NaturalProducts #Metabolomics #Microbiology www.jobs.ac.uk/job/DCX827/l...

@wildtypemc.bsky.social giving a great talk at @UFbiology

Genetics graduate student Sebastian Guerra representing our lab at the UF Genetics Institute research mixer

Artificial intelligence for natural product drug discovery | Nature Reviews Drug Discovery - a hugely enjoyable interdisciplinary & international collaborative effort from fantastic discussions during a @lorentzcenter workshop in 2021 www.nature.com/articles/s41...